With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50292-95-0,3,3-Bis(2-methyl-1-octyl-1H-indol-3-yl)isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.
Example A2:; A solution of 10.00 g Pergascript I-6B (RN 50292-95-0), 1.259 g dithiodiethanol and 3.95 g of toluene sulfonic acid monohydrate in 100ml chloroform is refluxed for 4 days with a water separator.After that time no separation of water is observed any more.The solvent is removed in vacuo and the crude product was purified by column chromatography (silica, toluene/acetone gradient).Yield: 1.78 g of the compound of formula(102) EPO
The synthetic route of 50292-95-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CIBA SPECIALTY CHEMICALS HOLDING INC.; WO2007/39528; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles