50820-65-0,50820-65-0, Methyl 1H-indole-6-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of compound 26 (2 g, 11.4 mmol) and cyclohexanone (3.36 g,34.2 mmol) in MeOH (15 mL), aqueous KOH (1.92 g, 34.2 mmol, dissolved in 13 mL water) was added. The resulting reaction mixture was stirred at 75 ¡ãC for 18 h. The progress of the reaction was monitored by LCMS. After completion, the reaction mixture was concentrated in vacuo. The residue was diluted with water, acidified with acetic acid pH?6; the obtained solidwas filtered; washed with water and dried in vacuo to afford the crude. The crude compound was triturated with IPA to afford compound 34 (1.6 g, 58percent) as light brown solid. ?H-NMR (400 MHz, DMSO-d6): oe 11.33 (s, 1H), 7.97 (s, 1H), 7.75 (d, J= 8.0 Hz, 1H), 7.61 (d, J= 8.4 Hz, 1H), 7.47 (s, 1H), 6.19 (s, 1H), 2.42 ?2.39 (m, 2H), 2.22 ? 2.20 (m, 2H), 1.76 – 1.72 (m, 4H). LCMS observed (m/z): 242 (M+1).
As the paragraph descriping shows that 50820-65-0 is playing an increasingly important role.
Reference£º
Patent; ASSEMBLY BIOSCIENCES, INC.; TURNER, William; ARNOLD, Lee, Daniel; LI, Leping; BURES, Mark; HAYDAR, Simon; MAAG, Hans; BANNEN, Lynne; (176 pag.)WO2018/53157; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles