Tag: 51417-51-7

51417-51-7, 7-Bromoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

51417-51-7, 7-Bromo-1H-indole (196 mg, 1.0 mmol, 1.0 equiv), NaOH (224 mg, 5.6 mmol, 5.6 equiv) and CH3I (284 mg, 2.0 mmol, 2.0 equiv) were stirred in THF (12.5 mL) at rt for 4 h. Work-up by filtration of salts and extraction (Et2O/H2O). Purification through a column chromatography [Rf=0.8 (10% ethyl acetate in hexane)] to afford 15 as a white solid (176 mg, 84%), mp: 52-54 C; IR (KBr): 3101, 3061, 2949, 2919, 1607, 1557, 1487, 1445, 1381, 1297, 1103, 918, 781, 711, 577 cm-1; 1H NMR (600 MHz, CDCl3): delta 7.54 (d, J=7.8 Hz, 1H), 7.35 (d, J=7.2 Hz, 1H), 7.00 (d, J=3.0 Hz, 1H), 6.92 (t, J=7.8 Hz, 1H), 6.47 (d, J=3.0 Hz, 1H), 4.17 (s, 3H); 13C NMR (150 MHz, CDCl3): delta 133.1, 131.7, 131.7, 126.5, 120.5, 120.3, 103.9, 101.2, 36.8; HRMS [(EI), M+]: 208.9839 (calcd for C9H8BrN 208.9840).

The synthetic route of 51417-51-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fan-Chiang, Tai-Ting; Wang, Hung-Kai; Hsieh, Jen-Chieh; Tetrahedron; vol. 72; 36; (2016); p. 5640 – 5645;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51417-51-7,7-Bromoindole,as a common compound, the synthetic route is as follows.

196 mg (1 mmol) of 7-bromoindole, 122.4 mg (1.2 mmol) of 5-hydroxy-2-pentanone and 25.6 mg (0.05 mmol) of tris(pentafluorophenyl)boron were added to a 10 mL reaction tube.Stir the reaction at 40 C and monitor by TLC until the sputum disappears.The reaction mixture was extracted with 3¡Á20 mL ethyl acetate.Combine the organic phase,Wash with saturated brine and dry over anhydrous sodium sulfate.Evaporation of the solvent ethyl acetate under reduced pressure and chromatography (ethyl ether: ethyl acetate = 20:1) to give 3-(tetrahydro-2-methyl-2-furanyl)-7-bromo 1H-indole The hydrazine product was 258 mg, yield: 92%.

51417-51-7 7-Bromoindole 2757020, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Huazhong University of Science and Technology; Wang Shijun; Xia Sang; Tang Xiangying; (18 pag.)CN109912579; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

51417-51-7, 7-Bromoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Anaerobic conditions,Cooled to 0 C with ice brine,Anhydrous DMF (2.5 g, 34 mmol) was taken in a 100 mL round bottom flask,P0C13 (1.4 g, 8.5 mmol) was added dropwise slowly,After about 10 minutes,0 C to continue the reaction for 30 minutes,Then 7-bromoindole (1.lg, 5.7mmol) was dissolved in 10 mL of DMF and slowly added dropwise to the reaction flask,After about 30 minutes at 0 C,Slowly rose to room temperature,The reaction was carried out for 5 hours,After TLC detection reaction was complete,The first reaction solution was added with saturated NaC03 solution,Adjusted to PH alkaline,While a large number of white solids appear,filter,The filter cake was washed 3 times with 100 mL of water,Dried to a yield of 1.2 g,Yield 94%.

51417-51-7 7-Bromoindole 2757020, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Tianjin University of Science & Technology; YU, PENG; WANG, YIQIAN; JIA, HAIYONG; WEN, SHAOPENG; LYU, LEI; GUO, NA; HAN, KAILIN; CHU, JIE; WANG, TIANJIAO; (13 pag.)CN103864779; (2016); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles