Tag: 52415-29-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52415-29-9,6-Bromoindole,as a common compound, the synthetic route is as follows.

Example 15 1H-Indole-6-carbaldehyde Combine hexane washed potassium hydride (1.3 g, 10.7 mmol) and ether (20 ml). Cool to about 0 C and add a solution of 6-bromo-1H-indole (2.1 g, 10.7 mmol) in ether (5 ml). After 15 min, cool to about -78C and add a solution of t-butyllithium, 1.4 M solution in hexane (14.0 ml, 10.7 mmol). After 10 min, add dimethylformamide (1.7 ml, 20.0 mmol) in ether (5ml). Slowly warm to room temperature and then pour into a ice cold solution of 1M phosphoric acid and extract with EtOAc. Combine the organic layers and wash sequentially with distilled water and brine and then dry (Na2SO4), filter, and concentrated to give a residue. Chromatograph the residue eluting with 9:1 hexane:EtOAc to give the title compound., 52415-29-9

52415-29-9 6-Bromoindole 676493, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; Chen, Zhaogen; Cohen, Michael Philip; Fisher, Matthew Joseph; Gillig, James Ronald; McCowan, Jefferson Ray; Miller, Shawn Christopher; Schaus, John Mehnert; Giethlen, Bruno; (141 pag.)EP1859798; (2015); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52415-29-9,6-Bromoindole,as a common compound, the synthetic route is as follows.

52415-29-9, To a stirred suspension of 60% sodium hydride (4.88 g, 122 mmol) in tetrahydrofuran (1 50 mL) was added 6-bromoindole (1 5.0 g, 76.5 mmol) portionwise, followed by methyl iodide (1 1.9 g, 83.8 mmol) dropwise and the mixture stirred at room temperature for 16 h. After this time, the reaction was poured into ice-cold water and extracted with ethyl acetate (2 x 100 mL). The combined organic layers were washed sequentially with water, then brine and dried over sodium sulfate. The drying agent was removed by filtration and the filtrate concentrated under reduced pressure to afford 6-bromo-l -methyl -1 H-indole as a pale red solid: NMR (400 MHz, CDC13) d 7.49 (m, 2H), 7.22 (dd, J = 8.0, 1.6 Hz, 1 H), 7.04 (d, J = 3.2 Hz, 1 H), 6.47 (d, J = 3.2 Hz, 1 H), 3.77 (s, 3H).

The synthetic route of 52415-29-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles