74420-02-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74420-02-3,4-Hydroxy-7-azaindole,as a common compound, the synthetic route is as follows.
To a solution of compound lH-pyrrolo[2,3-]pyridin-4-ol (0.1 mmol, 13.4 mg, prepared generally according to the procedures outlined by Thibault, C. et al.Org. Lett. 2003, 5, 5023-5025, the disclosure of which is incorporated by reference, in DMF (1 mL) was added cesium carbonate (Aldrich, 0.25 mmol, 81 mg). The mixture was stirred at room temperature for 0.5 h. To this mixture was added 2,4,5-trifluoro- iV-(l-(4-fluorophenyl)-2-oxo-l,2-dihydropyridin-3-yl)beiizamide (36 mg, 0.1 mmol). The reaction mixture was heated at 60 0C for 8 h. After the reaction mixture was cooled to room temperature, 2 mL of cold water was added. The reaction mixture was extracted with EtOAc (3 x 20 mL). The organic extracts were dried with MgSO4, concentrated in vacuo, and purified by preparative HPLC. The desired fractions were combined, concentrated in vacuo, and lyophilized to dry to give the title compound (trifluoroacetic acid salt, 10.0 mg, 21percent yield) as a white solid. 1H NMR (CD3OD) delta 8.61 (d, IH, J= 5.7 Hz), 8.26 (d, IH, J= 6.6 Hz), 8.02 (dd, IH, J= 11.0, 6.6 Hz), 7.51 (d, IH, J= 3.9 Hz), 7.29-7.25 (m, 3H), 7.36 (d, IH, J= 6.6 Hz), 7.25 (t, 2H, J= 8.8 Hz), 6.90 (d, IH, J= 6.6 Hz), 6.60 (d, IH, J= 3.3 Hz), 6.50 (t, IH, J= 7.2 Hz); MS(ESI+) m/z All..22 (M + H)+.
74420-02-3 4-Hydroxy-7-azaindole 12646048, aindole-building-block compound, is more and more widely used in various.
Reference£º
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Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles