With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.913287-12-4,Ethyl 5-fluoro-7-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
1.85 g (6.15 mmol) of ethyl 5-fluoro-7-nitro-1H-indole-2-carboxylate were initially charged in 20 ml of ethanol, admixed with 517 mg (9.22 mmol) of potassium hydroxide and stirred under reflux overnight. Subsequently, ethyl acetate was added, the mixture was extracted with 1 M sodium hydroxide solution and the pH of the aqueous phase was adjusted to pH 2 with hydrochloric acid.The mixture was extracted repeatedly with ethyl acetate, the organic phase was washed with saturated sodium chloride solution and dried over magnesium sulfate, filtered and concentrated. This gave 1.35 g (98% of theory) of the title compound.1H-NMR (400 MHz, DMSO-d6): delta=7.37 (d, 1H), 8.12 (dd, 1H), 8.16 (dd, 1H), 11.3 (s, 1H), 13.7 (s, 1H).
As the paragraph descriping shows that 913287-12-4 is playing an increasingly important role.
Reference£º
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/183928; (2011); A1;,
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