913836-24-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.913836-24-5,tert-Butyl 4-nitro-1H-indole-1-carboxylate,as a common compound, the synthetic route is as follows.
To a stirred solution of 1-Boc-4-nitroindole (6.14 g, 23.4 mmol) in EtOH (100 mL) was added 10% Pd/C (614 mg) under N2. The resulting mixture was shaken under hydrogen (H2, 50 psi) at room temperature for 8 h. The mixture was filtered through a pad of Celite, and washed with EtOH. The filtrate was concentrated under reduced pressure to give the product 1-Boc-4-aminoindole as off-white solid (5.23 g, 96% yield). MS (ESI) m/z 233.2
As the paragraph descriping shows that 913836-24-5 is playing an increasingly important role.
Reference£º
Patent; Wyeth; US2009/227575; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles