Tag: 93957-49-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93957-49-4,3-(4-Fluorophenyl)-1-isopropyl-1H-indole,as a common compound, the synthetic route is as follows.,93957-49-4

The reaction and post treatment were conducted in the same manner as in Example 8 except that acids shown in Table 1 were used instead of phosphorus oxychloride, the amount of glacial acetic acid was 6 mL and conditions shown in Table 1 were used, to obtain methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). The results are shown in Table 1.

As the paragraph descriping shows that 93957-49-4 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP1666440; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93957-49-4,3-(4-Fluorophenyl)-1-isopropyl-1H-indole,as a common compound, the synthetic route is as follows.,93957-49-4

Temperature 25 ¡À 5 C, to a 2000L reactor in 1,2 Dichloroethane 504.0kg (5mL / g), the main material of 3- (4-fluorophenyl) -1-isopropyl–1H- indole 80kg (315.8mol, 1.0equiv. ) And N- bromosuccinimide 67.5kg (379.0mol, 1.2 equiv.). The reaction system was heated to reflux, HPLC detected until the end of the reaction. The system pushed A saturated aqueous solution of sodium bisulfite in 480.0kg (5mL / g) to terminate the reaction. Standing, liquid separation, The organic phase was concentrated, then ethanol was added 126.4kg (2mL / g) was recrystallized from 2-bromo-halo 3- (4-fluorophenyl) -1-isopropyl–1H- indole 89.2kg, 96.0% pure liquid, yield 85.0%.

93957-49-4 3-(4-Fluorophenyl)-1-isopropyl-1H-indole 736229, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; ASYMCHEM INC; ASYMCHEM LIFE SCIENCE TIANJIN CO LTD; ASYCHEM PHARMACEUTICALS TIANJIN CO LTD;; ASYMCHEM LAB FUXIN INC; Jilin Asymchem Laboratories Co., Ltd; Hong, Hao; Ma, Jian Guo; Li, jiuyuan; Huang, Jun; (12 pag.)CN103342721; (2016); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.93957-49-4,3-(4-Fluorophenyl)-1-isopropyl-1H-indole,as a common compound, the synthetic route is as follows.

Examples 19 to 20 The reaction and post treatment were conducted in the same manner as in Example 14 except that acids shown in Table 3 were used instead of phosphorus oxychloride and the reaction time was 19 hours, to obtain methyl trans-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]acrylate (yellow solid). The results are shown in Table 3.

The synthetic route of 93957-49-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company, Limited; EP1666440; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles