Tag: M.W:100-200

Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins. Author is Khorwal, Vijaykant; Sadhu, Biswajit; Dey, Arghya; Sundararajan, Mahesh; Datta, Anindya.

2-(4′-Pyridyl)benzimidazole (4PBI) can exist in several states of protonation, having three basic nitrogen atoms. The equilibrium involving these states, in ground as well as in excited states, are found to be affected significantly by cyclodextrins (CDs). The formation of inclusion complexes of this compound with all three varieties of cyclodextrins is observed to be more favorable at pH 9 than at pH 4, due to the predominance of the neutral form of dye at pH 9. The binding affinity of 4PBI to CDs is found to be governed by two factors: (i) the size of the host and (ii) the mode of insertion of 4PBI. We find that, for the host with a smaller cavity (α-CD), insertion of the dye with a pyridyl face is favored, whereas, for γ-CD, the preference is shifted toward the benzimidazole face of the dye. For β-CD, the binding affinity of the dye is maximum due to perfect cavity matching with the guest. A combination of steric factor and hydrogen bonding interaction is found to be responsible for modulation of the protonation-deprotonation equilibrium of the guest mol. in the inclusion complex. Surprisingly, a protonated form is found to be promoted upon inclusion in cyclodextrins, under certain conditions. This is an unusual behavior and has been rationalized by prototropism involving the hydroxyl protons of cyclodextrin mols.

The article 《Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins》 also mentions many details about this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides. Author is Moorthy, Jarugu Narasimha; Neogi, Ishita.

A variety of primary (mostly benzylic) alcs. react with o-phenylenediamine to give benzimidazoles in one pot using IBX in DMSO as the oxidant at room temperature Arylmethyl bromides also undergo oxidative cyclocondensation with o-phenylenediamine under similar conditions to give benzimidazoles in moderate yields, albeit at slightly elevated temperatures

The article 《IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides》 also mentions many details about this compound(2208-59-5)Product Details of 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Journal of Physical Chemistry called Photophysics of three pyridylbenzimidazoles in solution, Author is Brown, Robert G.; Entwistle, Neil; Hepworth, John D.; Hodgson, Kevin W.; May, Bernadette, the main research direction is fluorescence decay pyridylbenzimidazole; benzimidazole pyridyl hydrogen transfer alc.Computed Properties of C12H9N3.

Fluorescence decay time data are presented for the three benzimidazoles with pyridine substituted at the 2 position. The anomalous behavior of 2-(2′-pyridyl)benzimidazole in alcs. is explained in terms of the alc. facilitating H transfer from the imidazole ring to the pyridine N atom. The rate constants for this process are determined by studying the quenching of the fluorescence of 2-(2′-pyridyl)benzimidazole in cyclohexane by EtOH.

The article 《Photophysics of three pyridylbenzimidazoles in solution》 also mentions many details about this compound(2208-59-5)Computed Properties of C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Late-Stage Diversification by Selectivity Switch in meta-C-H Activation: Evidence for Singlet Stabilization, the main research direction is ruthenium catalyzed meta selective aromatic functionalization late stage diversification.Application of 1008-89-5.

The full control of site selectivity in C-H activation is paramount for the programmed late-stage functionalization of structurally complex structures. During the past decade, directing groups have revolutionized mol. synthesis in terms of ortho-selective C-H activation. In sharp contrast, a selectivity switch that guides the typical ortho- to remote meta-C-H activation has thus far proven elusive. Herein, we describe the realization of such a concept for a robust selectivity control in ruthenium catalysis. The distal C-H transformation was guided by key mechanistic insights into the mild, synergistic action of carboxylates and phosphines in ruthenium(II) catalysis. Our findings allowed remote selectivity in broadly effective late-stage diversification of structurally complex drugs and natural product mols., tolerating sensitive fluorescent dyes, drugs, lipids, peptides, nucleosides and carbohydrates.

Different reactions of this compound(2-Phenylpyridine)Application of 1008-89-5 require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C11H9N. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Redefining the Mechanistic Scenario of Carbon-Sulfur Nucleophilic Coupling via High-Valent Cp*CoIV Species. Author is Lopez-Resano, Sara; Martinez de Salinas, Sara; Garces-Pineda, Felipe A.; Moneo-Corcuera, Andrea; Galan-Mascaros, Jose Ramon; Maseras, Feliu; Perez-Temprano, Monica H..

Mechanism of carbon-sulfur bond formation during reductive elimination of 2-arylpyridine derivative 2-(2-CF3SC6H4)C5H4N from Co(III) half-sandwich cyclometalated 2-phenylpyridine complex [Cp*Co(SCF3)(phpy)] (Hphpy = 2-phenylpyridine) includes activation of Co(III) center by oxidation to Co(IV) with AgSCF3 reagent. The potential access to CoIV species for promoting transformations that are particularly challenging at CoIII still remains underexploited in the context of Cp*Co-catalyzed C-H functionalization reactions. Herein, we disclose a combined exptl. and computational strategy for uncovering the participation of Cp*CoIV species in a Cp*Co-mediated C-S bond-reductive elimination. These studies support the intermediacy of high-valent Cp*Co species in C-H functionalization reactions, under oxidative conditions, when involving nucleophilic coupling partners.

Different reactions of this compound(2-Phenylpyridine)COA of Formula: C11H9N require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Solvothermal Synthesis and Diverse Coordinate Structures of a Series of Luminescent Copper(I) Thiocyanate Coordination Polymers Based on N-Heterocyclic Ligands.Category: indole-building-block.

Solvothermal reactions of CuSCN with 4-amino-3,5-bis(3-pyridyl)-1,2,4-triazole (3-Abpt), 5-(4-pyridyl)tetrazole (4-Ptz), and 2-(n-pyridyl)benzimidazole (n-PyHBIm, n = 4, 3, 2) in MeCN afford six novel coordination polymers: [Cu5(SCN)5(3-Abpt)2]n (1), [Cu(SCN)(3-Abpt)]n (2), [Cu(SCN)(4-Ptz)]n (3), [Cu2(SCN)2(4-PyHBIm)]n (4), [Cu2(SCN)2(3-PyHBIm)]n (5), and [Cu2(SCN)2(2-PyBIm)(2-PyHBIm)]n (6). All these complexes were structurally characterized by x-ray diffraction anal. 1 Is the 1st example of a 1,1,1,3-μ4-tetradentate thiocyanate complex which displays a three-dimensional (3D) polymeric framework constructed from thiocyanate and tetradentate 3-Abpt. 2 Exhibits a two-dimensional (2D) 4.82 network constructed from unidentate thiocyanate and tridentate 3-Abpt. 3 Is a 1-dimensional (1D) ladder-like double-chain polymer assembled by bidentate thiocyanate and 4-Ptz ligands. 4 Shows a 2-dimensional 1,1,3-μ3-thiocyanate Cu 4.82 network where bidentate 4-PyHBIm locates at both sides of the 2-dimensional layer. 5 Displays a 2-dimensional 63 network constructing from 1,1,3-μ3-thiocyanate and bidentate 3-PyHBIm. 6 Is a 1-dimensional 21 helical chain polymer constructing from 1,3-μ2-thiocyanate and 2-PyBIm anion. Bond valence sum (BVS) anal. and magnetic susceptibility indicate that 6 is a mixed-valence compound The coordinate diversity of thiocyanate is discussed. 1-6 Are all thermally stable up to 230-290°. They exhibit yellow or blue luminescence originating from ligand-to-metal charge transfer or ligand-centered emission.

Different reactions of this compound(2-(Pyridin-4-yl)-1H-benzo[d]imidazole)Category: indole-building-block require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cook, Xinlan A. F.; Pantaine, Loic R. E.; Blakemore, David C.; Moses, Ian B.; Sach, Neal W.; Shavnya, Andre; Willis, Michael C. researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Recommanded Product: 2-Phenylpyridine.They published the article 《Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions》 about this compound( cas:1008-89-5 ) in Angewandte Chemie, International Edition. Keywords: biaryl preparation; aryl halide heteroaromatic sulfinate cross coupling palladium catalyst; cross-coupling; desulfination; palladium; pyridine; sulfone. We’ll tell you more about this compound (cas:1008-89-5).

Heteroaromatic sulfinates, e.g., I, are effective nucleophilic reagents in Pd(0)-catalyzed cross-coupling reactions with aryl halides e.g., 4-methoxy-bromobenzene. However, metal sulfinate salts can be challenging to purify and solubilize in reaction media, and are not tolerant to multi-step transformations. Here base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones were introduced. It was shown that, under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls, e.g., II. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

Different reactions of this compound(2-Phenylpyridine)Recommanded Product: 2-Phenylpyridine require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins. Author is Khorwal, Vijaykant; Sadhu, Biswajit; Dey, Arghya; Sundararajan, Mahesh; Datta, Anindya.

2-(4′-Pyridyl)benzimidazole (4PBI) can exist in several states of protonation, having three basic nitrogen atoms. The equilibrium involving these states, in ground as well as in excited states, are found to be affected significantly by cyclodextrins (CDs). The formation of inclusion complexes of this compound with all three varieties of cyclodextrins is observed to be more favorable at pH 9 than at pH 4, due to the predominance of the neutral form of dye at pH 9. The binding affinity of 4PBI to CDs is found to be governed by two factors: (i) the size of the host and (ii) the mode of insertion of 4PBI. We find that, for the host with a smaller cavity (α-CD), insertion of the dye with a pyridyl face is favored, whereas, for γ-CD, the preference is shifted toward the benzimidazole face of the dye. For β-CD, the binding affinity of the dye is maximum due to perfect cavity matching with the guest. A combination of steric factor and hydrogen bonding interaction is found to be responsible for modulation of the protonation-deprotonation equilibrium of the guest mol. in the inclusion complex. Surprisingly, a protonated form is found to be promoted upon inclusion in cyclodextrins, under certain conditions. This is an unusual behavior and has been rationalized by prototropism involving the hydroxyl protons of cyclodextrin mols.

The article 《Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins》 also mentions many details about this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides. Author is Moorthy, Jarugu Narasimha; Neogi, Ishita.

A variety of primary (mostly benzylic) alcs. react with o-phenylenediamine to give benzimidazoles in one pot using IBX in DMSO as the oxidant at room temperature Arylmethyl bromides also undergo oxidative cyclocondensation with o-phenylenediamine under similar conditions to give benzimidazoles in moderate yields, albeit at slightly elevated temperatures

The article 《IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides》 also mentions many details about this compound(2208-59-5)Product Details of 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Journal of Physical Chemistry called Photophysics of three pyridylbenzimidazoles in solution, Author is Brown, Robert G.; Entwistle, Neil; Hepworth, John D.; Hodgson, Kevin W.; May, Bernadette, the main research direction is fluorescence decay pyridylbenzimidazole; benzimidazole pyridyl hydrogen transfer alc.Computed Properties of C12H9N3.

Fluorescence decay time data are presented for the three benzimidazoles with pyridine substituted at the 2 position. The anomalous behavior of 2-(2′-pyridyl)benzimidazole in alcs. is explained in terms of the alc. facilitating H transfer from the imidazole ring to the pyridine N atom. The rate constants for this process are determined by studying the quenching of the fluorescence of 2-(2′-pyridyl)benzimidazole in cyclohexane by EtOH.

The article 《Photophysics of three pyridylbenzimidazoles in solution》 also mentions many details about this compound(2208-59-5)Computed Properties of C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles