Tag: M.W:100-200

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Late-Stage Diversification by Selectivity Switch in meta-C-H Activation: Evidence for Singlet Stabilization, the main research direction is ruthenium catalyzed meta selective aromatic functionalization late stage diversification.Application of 1008-89-5.

The full control of site selectivity in C-H activation is paramount for the programmed late-stage functionalization of structurally complex structures. During the past decade, directing groups have revolutionized mol. synthesis in terms of ortho-selective C-H activation. In sharp contrast, a selectivity switch that guides the typical ortho- to remote meta-C-H activation has thus far proven elusive. Herein, we describe the realization of such a concept for a robust selectivity control in ruthenium catalysis. The distal C-H transformation was guided by key mechanistic insights into the mild, synergistic action of carboxylates and phosphines in ruthenium(II) catalysis. Our findings allowed remote selectivity in broadly effective late-stage diversification of structurally complex drugs and natural product mols., tolerating sensitive fluorescent dyes, drugs, lipids, peptides, nucleosides and carbohydrates.

Different reactions of this compound(2-Phenylpyridine)Application of 1008-89-5 require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C11H9N. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Redefining the Mechanistic Scenario of Carbon-Sulfur Nucleophilic Coupling via High-Valent Cp*CoIV Species. Author is Lopez-Resano, Sara; Martinez de Salinas, Sara; Garces-Pineda, Felipe A.; Moneo-Corcuera, Andrea; Galan-Mascaros, Jose Ramon; Maseras, Feliu; Perez-Temprano, Monica H..

Mechanism of carbon-sulfur bond formation during reductive elimination of 2-arylpyridine derivative 2-(2-CF3SC6H4)C5H4N from Co(III) half-sandwich cyclometalated 2-phenylpyridine complex [Cp*Co(SCF3)(phpy)] (Hphpy = 2-phenylpyridine) includes activation of Co(III) center by oxidation to Co(IV) with AgSCF3 reagent. The potential access to CoIV species for promoting transformations that are particularly challenging at CoIII still remains underexploited in the context of Cp*Co-catalyzed C-H functionalization reactions. Herein, we disclose a combined exptl. and computational strategy for uncovering the participation of Cp*CoIV species in a Cp*Co-mediated C-S bond-reductive elimination. These studies support the intermediacy of high-valent Cp*Co species in C-H functionalization reactions, under oxidative conditions, when involving nucleophilic coupling partners.

Different reactions of this compound(2-Phenylpyridine)COA of Formula: C11H9N require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: 1008-89-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Aliphatic Group-Tethered Iridium Complex as a Theranostic Agent against Malignant Melanoma Metastasis. Author is Wu, Ke-Jia; Ho, Shih-Hsin; Dong, Jia-Yi; Fu, Ling; Wang, Shuang-Peng; Liu, Hao; Wu, Chun; Leung, Chung-Hang; Wang, Hui-Min David; Ma, Dik-Lung.

Malignant melanoma is a very aggressive form of skin cancer, with a low long-term survival rate. Developing multifunctional theranostic agents to simultaneously track and inhibit the activity of tumor targets is a potential strategy for combating melanoma metastasis. S100B expression is directly correlated with the degree of malignant metastatic melanoma and is overexpressed in the majority of malignant melanoma patients. Herein, the Ir(III) complex 7 was identified as a potent theranostic agent with nanomolar potency against S100B and selectivity over related substrates. Complex 7 exhibited desirable photophys. properties including a large Stokes shift and high photostability, while its long emission lifetime enabled its luminescence signal to be discriminated from a highly autofluorescent background by use of time-resolved emission spectroscopy. Importantly, complex 7 showed strong colocalization with S100B protein in melanoma cells with a stable signal up to at least 12 h, revealing its potential as a cellular probe for S100B. Moreover, complex 7 impeded the interaction between S100B and the C-terminus of p53 in the cytoplasm, thereby restoring the binding of p53 to its target promoters. Finally, complex 7 suppressed tumor growth and restrained lung metastases in vivo in two sep. melanoma mouse models. To our knowledge, complex 7 is the first reported theranostic agent for simultaneously monitoring S100B and suppressing malignant melanoma metastasis in vivo via targeting S100B protein.

The article 《Aliphatic Group-Tethered Iridium Complex as a Theranostic Agent against Malignant Melanoma Metastasis》 also mentions many details about this compound(1008-89-5)HPLC of Formula: 1008-89-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhou, Yuyang; Ding, Yangming; Huang, Yinhao; Cai, Leilei; Xu, Jiawei; Ma, Xiao published an article about the compound: 2-Phenylpyridine( cas:1008-89-5,SMILESS:C1(C2=CC=CC=C2)=NC=CC=C1 ).Recommanded Product: 2-Phenylpyridine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1008-89-5) through the article.

The reaction between an iridium(III) solvent complex and the histidine site of biomols. as one kind of novel bioconjugation approaches has received much attention during the past few years. To extend this novel bioconjugation approach into electrochemiluminescence (ECL) immunoassay and optimize the performances, three iridium(III) solvent complexes with different CN bidentate main ligands have been designed and synthesized in this work. Bovine serum albumin (BSA) as the standard histidine-rich protein is initially employed to evaluate the labeling performances by comparing the ECL intensity of the same amount of BSA labeled by different iridium(III) solvent complexes. Importantly, a magnetic beads-based sandwich immunoassay platform using Ir-dmpq (iridium(III) acetonitrile complex with 2-(3,5-dimethylphenyl)quinoline as the main ligand) as a structurally optimized labeling agent has been successfully constructed to detect C-reactive protein (CRP, an important biomarker of systemic inflammation in clinic), and the limit of detection based on this novel labeling agent could reach below 1 ng/mL, which may further pave the way for applications of the iridium(III) solvent complex in histidine-rich protein ECL labeling beyond fluorescence labeling.

The article 《Synthesis and Structural Optimization of Iridium(III) Solvent Complex for Electrochemiluminescence Labeling of Histidine-Rich Protein and Immunoassay Applications for CRP Detection》 also mentions many details about this compound(1008-89-5)Recommanded Product: 2-Phenylpyridine, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Four new compounds based on terephthalate and 2-(4-pyridyl)benzimidazole ligands. Author is Xia, Chang-Kun; Wu, Yun-Long; Xie, Ji-Min.

Four compounds based on H2BDC and PyBIm [H2BDC = 1,4-benzenedicarboxylic acid, PyBIm = 2-(4-pyridyl)benzimidazole], (PyBIm)(H2BDC)0.5 (1), Co(PyBIm)2(HBDC)(BDC)0.5 (2), Ni(PyBIm)2(HBDC)(BDC)0.5 (3), and Zn(BDC)(PyBIm).H2O (4), were synthesized by hydrothermal methods and characterized by x-ray diffraction. Compound 1 contains 2 types of H-bonding N-H···N and O-H···N, which connect the mols. into a 2D layer. Complex 2 crystallizes isostructural to 3 in triclinic space group P1̅, in 1D chains. The H-bonding interactions between uncoordinated N, N-H, and COOH groups in 2 connect the 1D chains into a 2D layer. Complex 4 displays a 1D structure, which is finally extended to a 3D supramol. framework by H-bonding and π-π packing interactions. The magnetic properties of 2 and 3 were studied as well.

After consulting a lot of data, we found that this compound(2208-59-5)Product Details of 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Sequence-specific fluorometric recognition of HIV-1 ds-DNA with zwitterionic zinc(II)-carboxylate polymers, Author is Sun, Bin; Zhao, Hai-Qing; Xie, Bao-Ping; Bai, Li-Ping; Jiang, Zhi-Hong; Chen, Jin-Xiang, the main research direction is HIV1 DNA fluorescent probe zwitterionic zinc carboxylate polymer; organic metal framework zwitterionic zinc carboxylate polymer synthesis; Crystal structure; Fluorescence detection; HIV-1 ds-DNA recognition; Water-stable MOF.Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.

Four water-stable zwitterionic zinc-carboxylate polymers are prepared by reacting N-carboxymethyl-(3,5-dicarboxy)-pyridinium bromide (H3CmdcpBr) with zinc(II) nitrate in the presence of NaOH, through adjusting the solvents and ancillary ligands. With H2O as the solvent and the absence of an ancillary ligand, a two-dimensional (2D) polymer network [Zn(Cmdcp)(H2O)]n (1) is formed. In a mixed H2O/DMF solvent and with the presence of chelating ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen) and 2-(4-pyridyl)benzimidazole (pbz), a one-dimensional (1D) polymer of {[Zn2(Cmdcp)(bipy)2(H2O)5](NO3)2·3H2O}n (2), a mononuclear ionic species of [Zn(phen)(H2O)4][Cmdcp] (3), and a 2D polymer of {[Zn(Cmdcp)(pbz)][pbz]·7H2O}n (4) are accordingly formed. Compounds 1-4 are characterized by IR, elemental analyses and single crystal X-ray crystallog. Compound 2 strongly adsorbs single-stranded DNA (ss-DNA) probe (denoted as P-DNA) labeled with carboxyfluorescein (FAM) and quenches its fluorescence via a photo-induced electron transfer process. If, however, a double-stranded DNA (ds-DNA) of the human immunodeficiency virus 1 (HIV-1 ds-DNA) is further present, the P-DNA interacts with the major groove in HIV-1 ds-DNA via Hoogsteen hydrogen bonding to form a rigid triplex structure. This results in partial or complete fluorescence recovery depending on the concentration of HIV-1 ds-DNA. The findings are applied in fluorometric sensing of HIV-1 ds-DNA. The calibration plot is linear in the 0-60 nM target DNA concentration range, with a 7.4 nM detection limit (at a signal-to-noise ratio of 3). The assay is highly specific and not interfered by one base pair mutated for complementary target HIV-1 ds-DNA, complementary ss-DNA, single-base pair mutated for complementary ss-DNA, non-specific ss-DNA sequences, and higher-order dimeric G-quadruplexes.

After consulting a lot of data, we found that this compound(2208-59-5)Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Salen-based hypercrosslinked polymer-supported Pd as an efficient and recyclable catalyst for C-H halogenation.Recommanded Product: 2-Phenylpyridine.

The first use of a salen-based hypercrosslinked polymer-supported Pd catalyst to carry out C-H halogenation was reported. This catalyst was effectively catalyze C-H bromination and chlorination even better than its homogeneous counterpart Pd(OAc)2. It also showed excellent reusability without loss of catalytic activity for ten cycles. A broad substrate scope was explored and moderate to excellent yields were obtained.

After consulting a lot of data, we found that this compound(1008-89-5)Recommanded Product: 2-Phenylpyridine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about A novel two-dimensional cadmium(II) complex: poly[diaquatris(μ4-cyclohexane-1,4-dicarboxylato)bis[2-(pyridin-4-yl)-1H-benzimidazole]tricadmium(II), the main research direction is crystal structure cadmium pyridinylbenzimidazole cyclohexanedicarboxylato aqua trinuclear complex; mol structure cadmium pyridinylbenzimidazole cyclohexanedicarboxylato aqua trinuclear complex; hydrogen bond cadmium pyridinylbenzimidazole cyclohexanedicarboxylato aqua trinuclear complex; pi stacking cadmium pyridinylbenzimidazole cyclohexanedicarboxylato aqua trinuclear complex; cadmium pyridinylbenzimidazole cyclohexanedicarboxylato aqua trinuclear complex thermal emission property; cadmium complex; crystal structure; dicarboxylate; metal-organic framework; two-dimensional coordination polymer.Computed Properties of C12H9N3.

The title compound, [Cd3(C8H10O4)3(C12H9N3)2(H2O)2]n or [Cd3(chdc)3(4-PyBIm)2(H2O)2]n, was synthesized hydrothermally from the reaction of Cd(CH3COO)2·2H2O with 2-(pyridin-4-yl)-1H-benzimidazole (4-PyBIm) and cyclohexane-1,4-dicarboxylic acid (1,4-chdcH2). The asym. unit consists of one and a half CdII cations, one 4-PyBIm ligand, one and a half 1,4-chdc2- ligands and one coordinated water mol. The central CdII cation, located on an inversion center, is coordinated by six carboxylate O atoms from six 1,4-chdc2- ligands to complete an elongated octahedral coordination geometry. The two terminal rotationally sym. CdII cations each exhibits a distorted pentagonal-bipyramidal geometry, coordinated by one N atom from 4-PyBIm, five O atoms from three 1,4-chdc2- ligands and one O atom from an aqua ligand. The 1,4-chdc2- ligands possess two conformations, i.e. e,e-trans-chdc2- and e,a-cis-chdc2-. The cis-1,4-chdc2- ligands bridge the CdII cations to form a trinuclear {Cd3}-based chain along the b axis, while the trans-1,4-chdc2- ligands further link adjacent one-dimensional chains to construct an interesting two-dimensional network.

After consulting a lot of data, we found that this compound(2208-59-5)Computed Properties of C12H9N3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Acidic properties of benzimidazoles and substituent effects. IV. Relationship between the acidities of N’-(substituted phenyl)arylamidines and ring closures to imidazole, the main research direction is benzimidazole substituent effect acidity; amidine aryl cyclization substituent effect; phenylenediamine cyclocondensation pyridinecarboxylic acid; LFER acidity benzimidazole pyridyl.Product Details of 2208-59-5.

Benzimidazoles I (R = H, Me, Cl, MeO, NO2; R1 = Ph, pyridinyl) were prepared by cyclocondensation of 1,2-(H2N)2C6H3R with R1CO2H in polyphosphoric acid at 170-80° or by cyclocondensation of 1,2-(H2N)2C6H3R with R1Me in the presence of S. Alternatively, I were also prepared by cyclization of amidines RC6H4NHC(:NH)R1 (II) by successive treatment with aqueous NaOCl and then with Na2CO3. Cyclization of II (R = C-3 substituted) by the latter method gave mixtures of C-7 and C-5 substituted benzimidazoles which were separated by crystallization Acidities of II increased with increasing electron withdrawing power of R, and, as the acidity of II increased, yields of I from cyclization of II decreased. Acidities of C-7 substituted I were correlated by the Taft equation with ρ = 0.45, whereas acidities of C-5 substituted I (R1 = pyridyl) were correlated by the Hammett equation with ρ = 1.3.

After consulting a lot of data, we found that this compound(2208-59-5)Product Details of 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 2208-59-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Visible-light-promoted synthesis of benzimidazoles. Author is Park, Sehyun; Jung, Jaehun; Cho, Eun Jin.

A simple and environmentally friendly synthetic method for benzimidazoles, which are important structural motifs in many applications owing to their various biol. functions, was developed. The reaction of o-phenylenediamine and a variety of aliphatic/aromatic aldehydes in methanol proceeds at room temperature with only natural sources, mol. oxygen and visible light.

After consulting a lot of data, we found that this compound(2208-59-5)SDS of cas: 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles