Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5457-28-3,1H-Indole-3-carbonitrile,as a common compound, the synthetic route is as follows.,5457-28-3

To a solution of 3-cyanoindole (1.0 g, 7.03 mmol) in DMC (10 ML), DABCO (0.079 g, 0.70 mmol) is added and the resulting solution is heated to reflux for 8 h.The reaction is cooled to RT, and diluted with EtOAc (40 ML) and H2O (40 ML).The organic layer is separated and washed in sequence with H2O (50 ML), 10% aqueous citric acid (2*40 ML) and H2O (4*40 ML).The organic layer is dried over anhydrous Na2SO4, filtered and concentrated under vacuum to give 3-cyano-1-methylindole (about 1.08 g, 98%) as an oil: 1H NMR (CDCl3) delta 7.74 (d, 1H), 7.53 (s, 1H), 7.40-7.28 (m, 3H), 3.83 (s, 3H); 13C NMR (CDCl3) 136.0, 135.6, 127.8, 123.8, 122.1, 119.8, 116.0, 110.4, 85.4, 33.6; MS m/z 156 [M+1]+.

5457-28-3 1H-Indole-3-carbonitrile 230282, aindole-building-block compound, is more and more widely used in various.

Reference£º
Patent; Dell, Steven; Lozanov, Mario Emilov; Shieh, Wen-Chung; US2004/59131; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1071973-95-9, 6-Methoxy-5-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of intermediate 10a: Diethylaluminum chloride 1 M in hexane (18.6 ml_, 18.6 mmol) was added dropwise at 0C to a solution of 6-methoxy-5-methyl-1 H-indole [CAS 1071973- 95-9] (2 g, 12.4 mmol) in CH2CI2(60 ml_). After 30 min at 0C, 2-(4-fluoro-2- methoxyphenyl)acetyl chloride 1a (3.3 g, 16.3 mmol, synthesis: see Example 1 ) in CH2CI2 (60 ml_) was added slowly at 0C. The reaction was stirred at 0C for 3 h. Ice-water was added and the precipitate was filtered off, washed with water, and dried under vacuum to provide 2-(4-fluoro-2-methoxyphenyl)-1 -(6-methoxy-5- methyl-1 H-indol-3-yl)ethanone 10a (3.15 g)., 1071973-95-9

The synthetic route of 1071973-95-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICALS, INC.; KATHOLIEKE UNIVERSITEIT LEUVEN; KESTELEYN, Bart, Rudolf, Romanie; BONFANTI, Jean-Francois; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; BARDIOT, Dorothee, Alice, Marie-Eve; MARCHAND, Arnaud, Didier, M; (86 pag.)WO2016/113371; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles