M.W:100-200 | - Page 4 of 382 - Indole Building Blocks

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Tris(benzhydryl) and Cationic Bis(benzhydryl) Ln(III) Complexes: Exceptional Thermostability and Catalytic Activity in Olefin Hydroarylation and Hydrobenzylation with Substituted Pyridines, the main research direction is aralkyl pyridine preparation chemoselective regioselective; alkyl pyridine olefin hydroarylation lanthanum catalyst; lutidine olefin hydrobenzylation lanthanum catalyst.Recommanded Product: 1008-89-5.

A series of Ln(III) tris(benzhydryl) complexes [(p-tBu-C6H4)2CH]3Ln (Ln=La (1), Nd (2), Y (3)) were synthesized by the salt metathesis reactions of LnHal3(THF)3.5 (Ln = La, Nd, Hal = Cl; Ln = Y, Hal = I) and [(p-tBu-C6H4)2CH]Na. In 1-3 the benzhydryl ligands are linked with the metal centers in η4-coordination mode. For diamagnetic complexes 1 and 3 a fluxional behavior was detected in solution Complexes 1-3 proved to be thermally stable: no decomposition was observed even after heating their solutions in toluene-d8 at 140° during 72 h. The reactions of 1 and 2 with B(C6F5)3 allowed for the synthesis of base-free cationic complexes [(p-tBu-C6H4)2CH]2Ln[(p-tBu-C6H4)2CHB(C6F5)3] (Ln = La (4), Nd (5)) which adopted the structure of a contact ion pair. Combinations of 1-3 and borane [B(C6F5)3, [Me2NHPh][B(C6F5)4], [Ph3C][B(C6F5)4]] as well as 4 and 5 were found to be highly efficient, regio- and chemoselective catalysts for hydroarylation and hydrobenzylation of C:C bonds of a variety of substrates with substituted pyridines. These catalysts enabled highly challenging transformations such as hydrobenzylation of 1,1-disubstituted and internal C:C bonds.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Although many compounds look similar to this compound(2208-59-5)Recommanded Product: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, numerous studies have shown that this compound(SMILES:C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole( cas:2208-59-5 ) is researched.Recommanded Product: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.Yang, Yan; Zeng, Ming-Hua; Zhang, Lai-Jun; Liang, Hong published the article 《A zinc(II) coordination polymer, [Zn4(o-bda)4(p-pbim)4]n, with strong blue fluorescence》 about this compound( cas:2208-59-5 ) in Journal of Coordination Chemistry. Keywords: zinc pyridylbenzimidazole phenylenediacetato polymeric complex preparation structure; crystal structure zinc pyridylbenzimidazole phenylenediacetato polymeric complex; fluorescence zinc pyridylbenzimidazole phenylenediacetato polymeric complex. Let’s learn more about this compound (cas:2208-59-5).

A zinc(II) coordination polymer, [Zn4(o-bda)4(p-pbim)4]n (1) (p-pbim = 4-pyridylbenzimidazole, o-bda2- = o-phenylenediacetic acid dianion), has been synthesized by hydrothermal method and characterized by elemental anal., IR, TG, photoluminescence and X-ray single crystal diffraction. Complex 1 crystallizes in a monoclinic system and space group P21/n, with a = 14.231(3) Å, b = 16.257(4) Å, c = 16.794(4) Å, β = 100.262(1)°, and Z = 8; R1 for 6475 observed reflections [I > 2σ(I)] was 0.0420. Complex 1 shows a bi-chain structure fabricated by the tetranuclear zinc unit. Two zinc(II) ions are five coordinate with distorted trigonal-bipyramid geometry and the other two zinc(II) ions are four coordinate with distorted tetrahedral geometry. Complex 1 builds the 1-D bi-chain structure with two different sub-rings A and B, which are 32-member and 14-member rings, resp. There exists a 2-D supramol. network linked by hydrogen-bonding interactions (2.695 and 2.807 Å). A 3-D supramol. network is further constructed by non-covalent interactions between the 1-D bi-chain structure. The TG/DTG shows that the chain skeleton is thermally stable to 356°C. Blue fluorescent emission of the complex was determined at 404 nm in the solid state with short decay lifetime of 1.67 ns.

A new synthetic route of 1008-89-5

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Visible-Light-Induced C4-Selective Functionalization of Pyridinium Salts with Cyclopropanols, Author is Vellakkaran, Mari; Kim, Taehwan; Hong, Sungwoo, which mentions a compound: 1008-89-5, SMILESS is C1(C2=CC=CC=C2)=NC=CC=C1, Molecular C11H9N, Recommanded Product: 1008-89-5.

The site-selective C-H functionalization of heteroarenes is of considerable importance for streamlining the rapid modification of bioactive mols. A general strategy for visible-light-induced β-carbonyl alkylation at the C4 position of pyridines with high site selectivity using various cyclopropanols and N-amidopyridinium salts. In this process, hydrogen-atom transfer between the generated sulfonamidyl radicals and O-H bonds of cyclopropanols generates β-carbonyl radicals, provided efficient access to synthetically valuable β-pyridylated (aryl)ketones, aldehydes, and esters with broad functional-group tolerance. In addition, the mild method served as an effective tool for the site-selective late-stage functionalization of complex and medicinally relevant mols.

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After consulting a lot of data, we found that this compound(1008-89-5)Reference of 2-Phenylpyridine can be used in many types of reactions. And in most cases, this compound has more advantages.

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《On bio-MOF materials doped with phosphorescent iridium complexes for molecular oxygen determination: Synthesis, characterization and performance》. Authors are Xie, Jiali; Chen, Xiang; Li, Huanrong; Chen, Zhenbo.The article about the compound:2-Phenylpyridinecas:1008-89-5,SMILESS:C1(C2=CC=CC=C2)=NC=CC=C1).Reference of 2-Phenylpyridine. Through the article, more information about this compound (cas:1008-89-5) is conveyed.

In this paper, two phosphorescent Ir(III) complexes, Ir(ppy)2(Ln), were synthesized using 2-Ph pyridine (ppy) as the first (major) ligand and two phosphorous compounds (L1 and L2) as the auxiliary ligand. Their single crystal structure and electronic structure were discussed. Ir(ppy)2(Ln) complexes were doped into a supporting matrix of bio-MOF-1 via cationic exchange to ensure their uniform distribution. Their successful doping was confirmed by SEM, fluorescence microscopy image, XRD, N2 adsorption/desorption and ICP measurement. Their photophys. parameters, including absorption spectra, excitation spectra, emission spectra, emission lifetime and quantum yield, were discussed in detail. Their phosphorescent emission was confirmed by d. functional theory and emission lifetime, making them applicable for oxygen sensing. Linear working curves were observed for both composite samples, showing sensitivity as high as 23.65 with response/recovery time of 9/22 s. Humidity effect on sensing performance was limited. These parameters were found superior to literature ones based on phosphorescent Cu(I), RE(III), Ru(II) and Re(I) complexes. The sensing mechanism was revealed as a dynamic collision between Ir(ppy)2(Ln) and O2 mols. The novelty of this work was the combination of phosphorescent Ir(III) complexes with porous bio-MOF-1, resulting in greatly improved sensitivity and linear sensing with short response time.

After consulting a lot of data, we found that this compound(1008-89-5)Reference of 2-Phenylpyridine can be used in many types of reactions. And in most cases, this compound has more advantages.

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After consulting a lot of data, we found that this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Cobalt-mediated synthesis of 2-(4-pyridyl)benzimidazole. X-ray structures of Co[2-(4-pyridyl)benzimidazole]2(H2O)2(NO3)2 and [Co(isonicotinate)(4-pyridinium carboxylate)(H2O)(NO3)]∞. Author is Wang, Zhiyong; Wilson, Scott R.; Foxman, Bruce M.; Lin, Wenbin.

We have observed an unusual example of cobalt-mediated cyclization of 4-pyridinecarboxaldehyde and 2-nitroaniline to afford 2-(4-pyridyl)benzimidazole under hydro(solvo)thermal conditions. Reaction of Co(NO3)2·6H2O with 4-pyridinecarboxaldehyde and 2-nitroaniline in ethanol at 120° gave a cobalt(II) coordination compound, Co[2-(4-pyridyl)benzimidazole]2(H2O)2(NO3)2 (I). In contrast, when the hydro(solvo)thermal reaction was carried out between Co(NO3)2·6H2O and isonicotinic acid in the presence of 2-nitroaniline at 110°, a one-dimensional Co(II) coordination polymer with the formula of [Co(isonicotinate)(4-pyridinium carboxylate)(H2O)(NO3)]∞ (II) resulted. The x-ray single crystal structures of both I and II are described. Interestingly, the isonicotinic acid in II exists as a 4-pyridinium carboxylate tautomer, and the pyridinium hydrogen atom forms a very strong hydrogen bond to the carboxylate oxygen of the 4-pyridinium carboxylate on an adjacent metal center. I forms a three-dimensional polymeric network through hydrogen bonding interactions, while II exists as a 2-D bilayer polymeric network through hydrogen bonding interactions.

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Although many compounds look similar to this compound(1008-89-5)HPLC of Formula: 1008-89-5, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

HPLC of Formula: 1008-89-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Mitochondria-targeted artesunate conjugated cyclometalated iridium(III) complexes as potent anti-HepG2 hepatocellular carcinoma agents.

Hepatocellular carcinoma (HCC) poses a serious threat to people′s health worldwide. Artesunate (ART), one of the classical antimalarial drugs, has recently been shown to exert significant cytotoxicity in various cancers, but its bioavailability is low. Cyclometalated iridium(III) complexes have emerged as a promising class of anticancer therapeutic agents. Herein, through conjugation of two of them, three novel Ir(III)-ART conjugates, [Ir(C-N)2(bpy-ART)](PF6) (bpy = 2,2′-bipyridine, C-N = 2-phenylpyridine (ppy, Ir-ART-1), 2-(2-thienyl)pyridine (thpy, Ir-ART-2), and 2-(2,4-difluorophenyl)pyridine (dfppy, Ir-ART-3)) have been synthesized, and their potential as anti-HCC agents was evaluated. We demonstrate that Ir-ART-1-3 display higher cytotoxicity against HCC cell lines than normal liver cells, and they can especially locate to mitochondria of HepG2 cells and induce a series of mitochondria-mediated apoptosis events. Moreover, Ir-ART-1-3 can regulate the cell cycle and inhibit metastasis of HepG2 cells. Finally, in vivo antitumor evaluation also demonstrates the inhibitory activity of Ir-ART-1 on tumor growth. Taken together, these Ir(III)-ART conjugates have the potential to become drug candidates for future anti-HCC treatments.

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Although many compounds look similar to this compound(1008-89-5)Application In Synthesis of 2-Phenylpyridine, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Application In Synthesis of 2-Phenylpyridine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Regiodivergent C-H and Decarboxylative C-C Alkylation by Ruthenium Catalysis: ortho versus meta Position-Selectivity. Author is Korvorapun, Korkit; Moselage, Marc; Struwe, Julia; Rogge, Torben; Messinis, Antonis M.; Ackermann, Lutz.

Ruthenium(II) biscarboxylate complexes enabled the selective alkylation of C-H and C-C bonds at the ortho- or meta-position. Ortho-C-H alkylations were achieved with 4-, 5-, and 6-membered halocycloalkanes. Furthermore, the judicious choice of the directing group allowed for a full control of ortho-/meta-selectivities. Detailed mechanistic studies by experiment and computation were performed and provided strong support for an oxidative addition/reductive elimination process for ortho-alkylations, while a homolytic C-X cleavage was operative for the meta-selective transformations.

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Although many compounds look similar to this compound(1008-89-5)COA of Formula: C11H9N, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

COA of Formula: C11H9N. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging. Author is Conesa, Jose Javier; Carrasco, Ana C.; Rodriguez-Fanjul, Vanessa; Yang, Yang; Carrascosa, Jose L.; Cloetens, Peter; Pereiro, Eva; Pizarro, Ana M..

The iridium half-sandwich complex [Ir(η5:κ1-C5Me4CH2py)(2-phenylpyridine)]PF6 is highly cytotoxic: 15-250× more potent than clin. used cisplatin in several cancer cell lines. We have developed a correlative 3D cryo x-ray imaging approach to specifically localize and quantify iridium within the whole hydrated cell at nanometer resolution By means of cryo soft x-ray tomog. (cryo-SXT), which provides the cellular ultrastructure at 50 nm resolution, and cryo hard x-ray fluorescence tomog. (cryo-XRF), which provides the elemental sensitivity with a 70 nm step size, we have located the iridium anticancer agent exclusively in the mitochondria. Our methodol. provides unique information on the intracellular fate of the metallodrug, without chem. fixation, labeling, or mech. manipulation of the cells. This cryo-3D correlative imaging method can be applied to a number of biochem. processes for specific elemental localization within the native cellular landscape.

Our Top Choice Compound: 1008-89-5

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Monosubstituted, Anionic Imidazolyl Ligands from N-H NHC Precursors and Their Activity in Pd-Catalyzed Cross-Coupling Reactions, published in 2020-07-17, which mentions a compound: 1008-89-5, mainly applied to monosubstituted nitrogen heterocyclic carbene palladium complex preparation; aryl halide boronic acid Suzuki Miyaura Sonogashira coupling reaction, SDS of cas: 1008-89-5.

The treatment of several 2-diphenylphosphinoimidazoles with Pd(II) salts generates monosubstituted N-H NHC-Pd complexes via insertion into the C-P bond is reported. Removal of the N-H proton in situ leads to anionic (X-type) or imidazolyl-Pd complexes that are highly stable and catalytically active, achieving up to 340,000 turnovers at 1 ppm catalyst loading in Suzuki-Miyaura reactions. DFT-calculated Tolman electronic parameters for the sterically small ligands suggest that these ligands are significantly more donating than traditional NHCs, which provides a rationale for rapid cross-coupling catalysis. Excellent reactivity is also demonstrated in Sonogashira reactions.

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Although many compounds look similar to this compound(2208-59-5)Name: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, numerous studies have shown that this compound(SMILES:C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Syntheses, crystal structures and luminescent properties of three metal coordination polymers based on aromatic carboxylic acids and 2-(pyridine-4-yl)-(1H)-benzoimidazole, the main research direction is cobalt cadmium pyridineylbenzoimidazole isophthalate terephthalate complex preparation fluorescence thermolysis; crystal structure cobalt cadmium pyridineylbenzoimidazole isophthalate terephthalate complex.Name: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.

Three new metal coordination complexes, [Co(IPA)(4PBI)]·H2O (1), [Cd(IPA)(4PBI)(H2O)] (2) and [Cd(TPA)(4PBI)(H2O)] (3) [4PBI = 2-(pyridine-4-yl)-(1H)-benzoimidazole, IPA = isophthalate and TPA = terephthalate], were obtained under hydrothermal conditions by reacting cobalt and cadmium salts with 4PBI and IPA or TPA. Complexes 1-3 were structurally characterized by x-ray single-crystal diffraction, EA, IR and PXRD. All of these complexes display low dimensional features with 1-dimensional (1D) motifs. Complex 1 is a 1-dimensional tape-like structure containing bi-nuclear units, which is further extended into a 3-dimensional supramol. architecture through intermol. hydrogen bonds and stacking interactions. Complex 2 shows a 1-dimensional structural motif, which is further assembled into a 3-dimensional supramol. architecture by hydrogen bonds and packing interactions. Complex 3 is also a 1-dimensional chain. Through intermol. hydrogen bonds and π···π packing interactions, a 3-dimensional supramol. network is also generated for 3. The luminescent properties of complexes 2 and 3 were studied in the solid state at room temperature Addnl., TGA of 1-3 is discussed in details. CCDC 1436488-1436490.