Tag: M.W=150-200

Quality Control of 4-Hydroxyquinolin-2(1H)-one. Marjani, AP; Khalafy, J; Farajollahi, A in [Marjani, Ahmad Poursattar; Khalafy, Jabbar; Farajollahi, Ayda] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran published Synthesis of Ethyl 2-Amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates by a One-pot, Three-Component Reaction in the Presence of TPAB in 2019, Cited 41. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

Quality Control of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wu, ZQ; Wang, G; Li, ZL; Feng, EK; Liang, YP; Zhan, HJ; Liu, WY in TAYLOR & FRANCIS INC published article about in [Wu, Zhiqiang; Li, Zhenliang; Feng, Enke] Ningxia Normal Univ, Sch Chem & Chem Engn, Guyuan, Peoples R China; [Wu, Zhiqiang; Wang, Gang; Liang, Yanping; Zhan, Haijuan; Liu, Wanyi] Ningxia Univ, Coll Chem & Chem Engn, Natl Demonstrat Ctr Expt Chem Educ, State Key Lab High Efficiency Utilizat Coal & Gre, Yinchuan, Ningxia, Peoples R China in 2021.0, Cited 36.0. Recommanded Product: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Herein we report the multicomponent synthesis of the bis(indolyl)methane derivatives in a ball mill. The reaction was carried out under solvent-free conditions using only the Lewis acid-surfactant-SiO2 composite nanocatalyst (LASSC) prepared in situ. The unsymmetrical bis(indolyl) methane derivatives containing nitro or fluorine substitution with a yield of 72%-92% were obtained in a short reaction time. Within we verified that under the action of the combined catalyst of AlCl3 center dot 6H(2)O + SDS + SiO2, the method of preparing unsymmetrical bis(indolyl)methane by mechanical grinding without solvent has obvious advantages. Finally, we inspected that the catalysis system can be used eight times without a significant decrease in activity.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Wu, ZQ; Wang, G; Li, ZL; Feng, EK; Liang, YP; Zhan, HJ; Liu, WY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Lewis Acid-Activated Reactions of Silyl Ketenes for the Preparation of alpha-Silyl Carbonyl Compounds published in 2019. Recommanded Product: 98-17-9, Reprint Addresses Pentzer, EB (corresponding author), Texas A&M Univ, Dept Mat Sci & Engn, 3003 TAMU, College Stn, TX 77843 USA.; Pentzer, EB (corresponding author), Texas A&M Univ, Dept Chem, 3003 TAMU, College Stn, TX 77843 USA.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Silyl-substituted ketenes are attractive molecular building blocks due to their stability and ease of storage, as opposed to unstable alkyl and aryl ketenes. To better understand the reactivity of silyl ketenes and, in turn, their use in the preparation of highly functionalized small molecules, the reaction of silyl ketenes with different nucleophiles was studied. The addition of alcohol, amine, or thiol nucleophiles to the central carbon of silyl ketene, followed by proton transfer afforded alpha-silyl ester, amide, or thio-ester, respectively. Catalytic amounts of Lewis acid greatly increase the rate of the reaction, and the impact of nucleophile, Lewis acid, and silyl substituent are evaluated. The small molecules produced from these reactions give insight into the use of silyl ketenes as building blocks for complex molecular structures.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Mitchell, SM; Xiang, Y; Matthews, R; Arnburgey, AM; Pentzer, EB or concate me.. Recommanded Product: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. Authors Bornadiego, A; Neo, AG; Marcos, CF in MDPI published article about in [Bornadiego, Ana; Neo, Ana G.; Marcos, Carlos F.] Univ Extremadura, Dept Organ & Inorgan Chem, Lab Bioorgan Chem & Membrane Biophys LOBO, Caceres 10003, Spain in 2021.0, Cited 54.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery. Combining these two heterocycles provides unique rigid polycyclic peptidomimetics with drug-like properties including many points of diversity that could be modulated to interact with different biological receptors. This work describes an efficient multicomponent approach to condensed chromenopiperazines based on the novel enol-Ugi reaction. Importantly, this strategy involves the first reported post-condensation transformation of an enol-Ugi adduct.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Bornadiego, A; Neo, AG; Marcos, CF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. Wu, YB; Xiao, L; Mao, CL; Zang, ZL; Zhou, CH; Cai, GX in [Wu, Yun-Bin; Xiao, Lin; Mao, Chun-Li; Zang, Zhong-Lin; Zhou, Cheng-He; Cai, Gui-Xin] Southwest Univ, Key Lab Luminescent & Real Time Analyt Chem, Minist Educ,Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal,Inst Bioorg, Chongqing 400715, Peoples R China; [Cai, Gui-Xin] Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China published Regio- and Stereoselective Synthesis of Enynyl-Aryl Ethers Enabled by Copper/Iodide Tandem Catalysis in 2019, Cited 82. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

An approach to preparing enynyl-aryl ethers from phenols and phenylacetylenes is described. This method without extra ligands, overcoming the favored Glaser-Hay dimerization of alkyne, features a wide substrate scope (38 examples including endofolliculina and indole) and the merits of high atom and step economy, good regio- and stereoselectivity (Z-isomers major) in moderate to good isolated yields. Mechanistic studies show that the reaction is enabled by distinctive copper/iodide tandem catalysis.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, YB; Xiao, L; Mao, CL; Zang, ZL; Zhou, CH; Cai, GX or concate me.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MICROBIAL-PRODUCTION; SALICYLATE BIOSYNTHESIS; PURIFICATION; ENZYME, Saw an article supported by the National Research Foundation – Ministry of Education, Science and Technology [NRF-2019R1A2C1002714]; Next-Generation BioGreen 21 Program, Ministry of Education, Science and Technology, Republic of Korea [PJ01326001]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Choo, HJ; Ahn, JH. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one. Safety of 4-Hydroxyquinolin-2(1H)-one

Intermediates in aromatic amino acid biosynthesis can serve as substrates for the synthesis of bioactive compounds. In this study we used two intermediates in the shikimate pathway of Escherichia coli, chorismate and anthranilate, to synthesize three bioactive compounds: 4-hydroxycoumarin (4-HC), 2,4-dihydroxyquinoline (DHQ), and 4-hydroxy-1-methyl-2(1H)-quinolone (NMQ). We introduced genes for the synthesis of salicylic acid from chorismate to supply the substrate for 4-HC and the gene encoding N-methyltransferase for the synthesis of N-methylanthranilate from anthranilate. Polyketide synthases and coenzyme (Co)A ligases were tested to determine the optimal combination of genes for the synthesis of each compound. We also tested several constructs and identified the best one for increasing levels of endogenous substrates for chorismate, anthranilate, and malonyl-CoA. With the use of these strategies, 255.4 mg/L 4-HC, 753.7 mg/L DHQ, and 17.5 mg/L NMQwere synthesized. This work provides a basis for the synthesis of diverse coumarin and quinoline derivatives with potential medical applications.

Safety of 4-Hydroxyquinolin-2(1H)-one. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Choo, HJ; Ahn, JH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Recently I am researching about BIOLOGICAL EVALUATION; ANTIOXIDANT, Saw an article supported by the Shiraz University of Medical Sciences; [12626-106-01-95]. Published in WILEY in HOBOKEN ,Authors: Iraji, A; Panahi, Z; Edraki, N; Khoshneviszadeh, M; Khoshneviszadeh, M. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Due to the fact that tyrosinase is responsible for biosynthesis and regulation of melanins and browning food products, tyrosinase inhibitors can be favorable agents in cosmetics and medicinal industries. A series of novel 2-hydroxy-4-methoxybenzohydrazide were designed, synthesized, and their new application as tyrosinase inhibitors was also disclosed. Based on in vitro tyrosinase inhibitory assay, 4d as the strongest inhibitor of tyrosinase with an IC50 value of 7.57 mu M showed approximately 2.5-fold better inhibition than kojic acid as positive control followed by two compounds 4b (IC50 = 8.19 +/- 0.25 mu M) and 4j (IC50 = 8.92 +/- 0.016) which displayed preferable tyrosinase inhibitory activity. Detailed investigations on the mechanism of action of the 4d reported mix type of inhibition. More importantly, molecular modeling assessments proposed the ability of 4d for potential interaction with Cu (metal)-His (residue) within tyrosinase active site. Overall, 4d is a promising candidate for the development of anti-tyrosinase agents.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Iraji, A; Panahi, Z; Edraki, N; Khoshneviszadeh, M; Khoshneviszadeh, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O in [Burmaoglu, Serdar] Erzincan Binali Yildirim Univ, Tercan Vocat High Sch, TR-24800 Erzincan, Turkey; [Burmaoglu, Serdar; Yilmaz, Ali Osman; Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, Erzurum, Turkey; [Polat, M. Fatih] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Erzincan, Turkey; [Kaya, Ruya] Ibrahim Cecen Univ Agri, Cent Res & Applicat Lab, Agri, Turkey; [Algul, Oztekin] Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, Mersin, Turkey published Synthesis of novel tris-chalcones and determination of their inhibition profiles against some metabolic enzymes in 2021, Cited 86. Name: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. The compounds demonstrated K-i values between 13.6 +/- 1.1 and 50.0 +/- 17.1 nM on hCA I, 9.9 +/- 0.8 and 39.5 +/- 15.1 nM on hCA II, 3.1 +/- 0.2 and 20.1 +/- 1.9 nM on AChE, 4.9 +/- 0.4 and 14.7 +/- 5.2 nM on BChE and 3.9 +/- 0.2 and 22.4 +/- 10.7 nM on alpha-Gly enzymes. The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer’s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O or concate me.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Enantioselective Synthesis of 3,3 ‘-Disubstituted 2-Amino-2 ‘-hydroxy-1,1 ‘-binaphthyls by Copper-Catalyzed Aerobic Oxidative Cross-Coupling WOS:000620194400001 published article about ASYMMETRIC CATALYSIS; BINOL; DERIVATIVES; 2-NAPHTHOL; ACTIVATION; LIGANDS; ACID in [Zhao, Xiao-Jing; Li, Zi-Hao; Ding, Tong-Mei; Tian, Jin-Miao; Tu, Yong-Qiang; Wang, Ai-Fang; Xie, Yu-Yang] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Tu, Yong-Qiang] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2021, Cited 70. COA of Formula: C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A challenging direct asymmetric catalytic aerobic oxidative cross-coupling of 2-naphthylamine and 2-naphthol, using a novel Cu-I/SPDO system, has been successfully developed for the first time. Enantioenriched 3,3 ‘-disubstituted NOBINs were achieved and could be readily derived to divergent chiral ligands and catalysts. This reaction features high enantioselectivities (up to 96 % ee) and good yields (up to 80 %). The DFT calculations suggest that the F-H interactions between CF3 of L17 and H-1,8 of 2-naphthol, and the pi-pi stacking between the two coupling partners could play vital roles in the enantiocontrol of this cross-coupling reaction.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhao, XJ; Li, ZH; Ding, TM; Tian, JM; Tu, YQ; Wang, AF; Xie, YY or concate me.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 98-17-9. Authors Ning, L; Wang, SM; Du, L; Guo, BY; Zhang, JJ; Lu, HZ; Dong, YH in ROYAL SOC CHEMISTRY published article about in [Ning, Lei; Wang, Simin; Guo, Bingyi; Zhang, Jianjun; Lu, Huizhe; Dong, Yanhong] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China; [Ning, Lei; Wang, Simin; Guo, Bingyi; Zhang, Jianjun; Lu, Huizhe; Dong, Yanhong] China Agr Univ, Innovat Ctr Pesticide Res, Beijing 100193, Peoples R China; [Du, Lin] China Agr Univ, Coll Agron & Biotechnol, Beijing 100193, Peoples R China in 2021, Cited 41. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A series of azamacrolides containing the carbamate or urea moiety were synthesized and evaluated for their fungicidal activities against several agriculturally important pathogens. In addition, they were investigated for their ability to inhibit quorum sensing in Agrobacterium tumefaciens. The results showed that most of the derivatives had moderate to high fungicidal activities against the tested fungi, especially towards Sclerotinia sclerotiorum. Additionally, D16-19 could be used as a potential broad-spectrum fungicide while D16-4 exhibited a fungicidal activity (EC50 = 1.87 mg L-1) similar to that of carbendazim (EC50 = 1.34 mg L-1) against S. sclerotiorum. The three-dimensional Quantitative Structure-Activity Relationship (3D-QSAR) models were also established based on the experimental results and they would provide valuable information for further optimization. Moreover, D16-17 not only showed a better fungicidal activity against S. sclerotiorum but also had the highest ability to inhibit quorum sensing. These findings suggested that some azamacrolide compounds hold potential for the development of novel fungicides or inhibitors of quorum sensing.

SDS of cas: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ning, L; Wang, SM; Du, L; Guo, BY; Zhang, JJ; Lu, HZ; Dong, YH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles