Tag: M.W=150-200

COA of Formula: C9H10O3. Authors Song, JL; Hua, ML; Huang, X; Visa, A; Wu, TB; Fan, HL; Hou, MQ; Zhang, ZF; Han, BX in ROYAL SOC CHEMISTRY published article about in [Song, Jinliang; Hua, Manli; Huang, Xin; Wu, Tianbin; Fan, Honglei; Hou, Minqiang; Zhang, Zhaofu; Han, Buxing] Chinese Acad Sci, CAS Key Lab Colloid & Interface & Thermodynam, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China; [Hua, Manli; Huang, Xin; Han, Buxing] Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China; [Visa, Aurelia] Romanian Acad, Inst Chem Timisoara, 24 M Viteazul Ave, Timisoara 300223, Romania in 2021, Cited 44. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The Meerwein-Ponndorf-Verley (MPV) reaction is an attractive approach to selectively reduce carbonyl groups, and the design of advanced catalysts is the key for these kinds of interesting reactions. Herein, we fabricated a novel zirconium organoborate using 1,4-benzenediboronic acid (BDB) as the precursor for MPV reduction. The prepared Zr-BDB had excellent catalytic performance for the MPV reduction of various biomass-derived carbonyl compounds (i.e., levulinate esters, aldehydes and ketones). More importantly, the number of borate groups on the ligands significantly affected the catalytic activity of the Zr-organic ligand hybrids, owing to the activation role of borate groups on hydroxyl groups in the hydrogen source. Detailed investigations revealed that the excellent performance of Zr-BDB was contributed by the synergetic effect of Zr4+ and borate. Notably, this is the first work to enhance the activity of Zr-based catalysts in MPV reactions using borate groups.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Song, JL; Hua, ML; Huang, X; Visa, A; Wu, TB; Fan, HL; Hou, MQ; Zhang, ZF; Han, BX or concate me.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation WOS:000455285800003 published article about H FUNCTIONALIZATION; OXIDATIVE AMINATION; ELECTRON-TRANSFER; AMIDYL RADICALS; METAL; GENERATION; CLEAVAGE; ETHERS; ELECTROSYNTHESIS; HETEROARENES in [Chang, Xihao; Zhang, Qinglin; Guo, Chang] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China in 2019, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Safety of 3-(Trifluoromethyl)phenol

A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochemical radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochemical transformation, furnishing the corresponding amides in up to 86% yield.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Chang, XH; Zhang, QL; Guo, C or concate me.. Safety of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Physics very interesting. Saw the article Synthesis and (fluoro)solvatochromism of two 3-styryl-2-pyrazoline derivatives bearing benzoic acid moiety: A spectral, crystallographic and computational study published in 2021.0. Recommanded Product: 120-14-9, Reprint Addresses Matiadis, D (corresponding author), Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Athens 15310, Greece.; Papadakis, R (corresponding author), Uppsala Univ, Dept Chem Angstrom, S-75120 Uppsala, Sweden.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

In this work we report the synthesis of two fluorescent 2-pyrazoline derivatives exhibiting remarkable (fluoro) solvatochromic behavior. The pyrazolines were synthesized in one step from the corresponding monocarbonyl curcuminoids and 4-hydrazinobenzoic acid in high yield and purity and were fully characterized by means of NMR and FT-IR spectroscopy and HRMS spectrometry. The structure of the novel derivative 2was also characterized by means of X-ray crystallography. Both compounds were studied computationally in the gas phase. Additionally, the effects of solvent polarity on the absorption and fluorescence spectra of these derivatives were investigated in a solvent group consisting of various neat molecular solvents exhibiting hydrogen bond donating (HBD), hydrogen bond accepting (HBA), and/or dipolar behavior. The solvent effects observed were quantified and rationalized by employing suitable multiparametric Linear Solvation Energy Relationships (LSERs) involving dipolarity, HBD-acidity and HBA-basicity terms. The contribution of each of these parameters provided insights on the predominant solute-solvent interactions occurring in solution. Importantly, some differences in the (fluoro)solvatochromic aptitude/behavior were revealed among the derivatives and they were rationalized on the basis of their structural diversity. (C) 2021 Elsevier B.V. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Matiadis, D; Nowak, KE; Alexandratou, E; Hatzidimitriou, A; Sagnou, M; Papadakis, R or concate me.. Recommanded Product: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. SDS of cas: 120-14-9

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues WOS:000656969600006 published article about III POLYKETIDE SYNTHASE; NF-KAPPA-B; METABOLITES; MECHANISM; OXIDASE in [Wu, Wenxi; Mu, Yu; Liu, Bo; Wang, Zixuan; Guan, Peipei; Han, Li; Huang, Xueshi] Northeastern Univ, Coll Life & Hlth Sci, Inst Microbial Pharmaceut, Shenyang 110819, Peoples R China; [Jiang, Mingguo] Guangxi Univ Nationalities, Sch Marine Sci & Biotechnol, Guangxi Key Lab Polysaccharide Mat & Modificat, Nanning 530008, Peoples R China in 2021, Cited 25. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Category: indole-building-block

Violacin A, a chromanone derivative, isolated from a fermentation broth of Streptomyces violaceoruber, has excellent anti-inflammatory potential. Herein, a biogenetically modeled approach to synthesize violacin A and twenty-five analogues was described, which involved the preparation of aromatic polyketide precursor through Claisen condensation and its spontaneous cyclization. The inhibitory effect on nitric oxide (NO) production of all synthetic molecules was evaluated by lipopolysaccharide (LPS)-induced Raw264.7 cells. The results revealed that introduction of aliphatic amine moieties on C-7 obviously improved the anti-inflammation effect of violacin A, and also the aromatic ether instead of ketone group at side chain was favorable to increase the activity. Among them, analogue 7a and 16d were screened as the most effective anti-inflammatory candidates. Molecular mechanism research revealed that 7a and 16d acquired anti-inflammatory ability due to the inhibition of NF-KB signaling pathway.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, WX; Mu, Y; Liu, B; Wang, ZX; Guan, PP; Han, L; Jiang, MG; Huang, XS or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers WOS:000473116000011 published article about C-C; INTRAMOLECULAR HYDROALKOXYLATION; INTERMOLECULAR HYDROALKOXYLATION; HIGHLY EFFICIENT; ALKYNES; HYDROAMINATION; COMPLEXES; TRANSFORMATION; CYCLOISOMERIZATION; ACETALS in [Laserna, Victor; Rojas, Catherine Jeapes; Sheppard, Tom D.] UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England in 2019, Cited 43. HPLC of Formula: C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

HPLC of Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laserna, V; Rojas, CJ; Sheppard, TD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C9H10O3. In 2021.0 ENVIRON SCI TECHNOL published article about PHASE REACTIONS; IONIC-STRENGTH; RATE CONSTANTS; PHOTOCHEMICAL DEGRADATION; MOLECULAR COMPOSITION; HYDROXYL RADICALS; LIGHT-ABSORPTION; EMISSION FACTORS; BROWN CARBON; OXIDATION in [Ma, Lan; Guzman, Chrystal; Tran, Theodore; Anastasio, Cort] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA; [Niedek, Christopher; Zhang, Qi] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA in 2021.0, Cited 80.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Biomass burning emits large amounts of phenols, which can partition into cloud/fog drops and aerosol liquid water (ALW) and react to form aqueous secondary organic aerosol (aqSOA). Triplet excited states of organic compounds (C-3*) are likely oxidants, but there are no rate constants with highly substituted phenols that have high Henry’s law constants (K-H) and are likely important in ALW. To address this gap, we investigated the kinetics of six highly substituted phenols with the triplet excited state of 3,4-dimethoxybenzaldehyde. Second-order rate constants at pH 2 are all fast, (2.6-4.6) x 10(9) M-1 s(-1), while values at pH 5 are 2-5 times smaller. Rate constants are reasonably described by a quantitative structure-activity relationship with phenol oxidation potentials, allowing rate constants of other phenols to be predicted. Triplet-phenol kinetics are unaffected by ammonium sulfate, sodium chloride, galactose (a biomass-burning sugar), or Fe(III). In contrast, ammonium nitrate increases the rate of phenol loss by making hydroxyl radicals, while Cu(II) inhibits phenol decay. Mass yields of aqueous SOA from triplet reactions are large and range from 59 to 99%. Calculations using our data along with previous oxidant measurements indicate that phenols with high KH can be an important source of aqSOA in ALW, with 3C* typically the dominant oxidant.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Ma, L; Guzman, C; Niedek, C; Tran, T; Zhang, Q; Anastasio, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 86-95-3. In 2021 ANTIVIR RES published article about NONCANONICAL POLY(A) POLYMERASE; POLYADENYLATION SIGNAL; MOLECULAR-BIOLOGY; STEM-LOOP; VIRUS; DEGRADATION; EXOSOME; TRAMP; DECAY; TRANSCRIPTS in [Block, Timothy M.; Zhou, Tianlun] Baruch S Blumberg Inst, Doylestown, PA 18902 USA; [Young, John A. T.] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland; [Javanbakht, Hassan] SQZ Biotechnol, 200 Arsenal Yards Blvd,Suite 210, Watertown, MA 02472 USA; [Sofia, Michael J.] Arbutus Biopharma Inc, 701 Vet Circle, Warminster, PA 18974 USA in 2021, Cited 69. The Name is 4-Hydroxyquinolin-2(1H)-one. Through research, I have a further understanding and discovery of 86-95-3.

Inhibition of the host RNA polyadenylating polymerases, PAPD5 and PAPD7 (PAPD5/7), with dihydroquinolizinone, a small orally available, molecule, results in a rapid and selective degradation of hepatitis B virus (HBV) RNA, and hence reduction in the amounts of viral gene products. DHQ, is a first in class investigational agent and could represent an entirely new category of HBV antivirals. PAPD5 and PAPD7 are noncanonical, cell specified, polyadenylating polymerases, also called terminal nucleotidyl transferases 4B and 4A (TENT4B/A), respectively. They are involved in the degradation of poor-quality cell transcripts, mostly noncoding RNAs and in the maturation of a sub-set of transcripts. They also appear to play a role in shielding some mRNA from degradation. The results of studies with DHQ, along with other recent findings, provide evidence that repression of the PAPD5/7 arm of the cell RNA quality control pathway, causes a profound (multifold) reduction rather than increase, in the amount of HBV pre-genomic, pre-core and HBsAg mRNA levels in tissue culture and animal models, as well. In this review we will briefly discuss the need for new HBV therapeutics and provide background about HBV transcription. We also discuss cellular degradation of host transcripts, as it relates to a new family of anti-HBV drugs that interfere with these processes. Finally, since HBV mRNA maturation appears to be selectively sensitive to PAPD5/7 inhibition in hepatocytes, we discuss the possibility of targeting host RNA quality control as an antiviral strategy.

Recommanded Product: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Block, TM; Young, JAT; Javanbakht, H; Sofia, MJ; Zhou, TL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. I found the field of Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiology very interesting. Saw the article Synthesis of novel tris-chalcones and determination of their inhibition profiles against some metabolic enzymes published in 2021, Reprint Addresses Burmaoglu, S (corresponding author), Erzincan Binali Yildirim Univ, Tercan Vocat High Sch, TR-24800 Erzincan, Turkey.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. The compounds demonstrated K-i values between 13.6 +/- 1.1 and 50.0 +/- 17.1 nM on hCA I, 9.9 +/- 0.8 and 39.5 +/- 15.1 nM on hCA II, 3.1 +/- 0.2 and 20.1 +/- 1.9 nM on AChE, 4.9 +/- 0.4 and 14.7 +/- 5.2 nM on BChE and 3.9 +/- 0.2 and 22.4 +/- 10.7 nM on alpha-Gly enzymes. The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer’s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Burmaoglu, S; Yilmaz, AO; Polat, MF; Kaya, R; Gulcin, I; Algul, O or concate me.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. In 2019 SYNOPEN published article about DIRECT N-ALKYLATION; O-ALKYLATION; REDUCTIVE AMINATION; ARYL ETHERS; EFFICIENT SYNTHESIS; AROMATIC-AMINES; ALCOHOLS; PHENOLS; ANILINES; DERIVATIVES in [Jagtap, Sangeeta V.] Baburaoji Gholap Coll, Dept Chem, Pune 411027, Maharashtra, India; Savitribai Phule Pune Univ, Pune, Maharashtra, India in 2019, Cited 115. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A simple and efficient protocol for base-mediated selective synthesis of 2-(arylamino)ethanols from primary aromatic amines and 2-aryloxyethanols from phenols, promoted by K (2) CO (3) has been achieved under mild conditions. Even in presence of excess alkyl halide, selective mono-N-alkylation has been achieved. Tolerance of a variety of functional groups is demonstrated by 15 examples of selective N-alkylation of aromatic amines and 19 examples of O-alkylation of phenols. The efficacy of the protocol is demonstrated by the formal synthesis of Ticlopidine (-(R)) , Vildagliptin (R) , Quetiapine (R) , and Gemfibrozil (R).

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Sonawane, RB; Sonawane, SR; Rasal, NK; Jagtap, SV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles