Tag: M.W=150-200

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Authors Nayak, SS; Wadhawa, GC; Shivankar, VS; Patil, DD; Sonawale, MC; Mirgane, NA in ELSEVIER published article about in [Nayak, Shubhada S.; Wadhawa, Gurumeet C.] Karmaveer Bhaurao Patil Coll, Rayat Shikshan Sansthas, Vashi Sect 15 A Navi, Mumbai 400703, Maharashtra, India; [Shivankar, Vitthal S.] Chhatrapati Shivaji Coll, Rayat Shikshan Sansthas, Satara, Maharashtra, India; [Patil, Dinanath D.] SMBT Coll Sangamner, Sangamner 422605, MH, India; [Sonawale, Maryappa C.] Veer Wajekar ASC Coll, Raigad, MH, India; [Mirgane, Nitin A.] SIES Coll ASC, Dept Chem, Mumbai, Maharashtra, India in 2021.0, Cited 54.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The nanoscience is emerging field of the science and technology. In nanoscience research synthesizing green nanoparticles using green protocols are very good, effective technique, quite safe and ecofriendly technique compared to the conventional chemical and physical methods. These are used in the various field of science. These are used in the catalysis. Theses green and bio-based route for the preparation of the nanoparticles has good attention in the organic synthesis. These nano catalysts used for synthesis of heterocyclic compound. Imidazole and their derivatives are widely used. The imidazole and its derivatives are very important heterocyclic compounds. They have very good biological and pharmaceutical activity. In this we have prepared plant assisted tin oxide nanoparticles from the leaves of Ceropegia jainii plant by the green methods. The synthesized nanoparticles are characterized by various methods of analysis. These synthesized plants assisted nanoparticles are used for the synthesis of the heterocycles. We have developed the simple and highly efficient three component such as benzil, aromatic aldehyde and ammonium acetate under the microwave irradiation without any solvent. This reaction gives the 2,4,5-triarylimidazole derivatives with good yield and purity. This method is very simple and cost effective. Nano catalyst are green and recyclable with very less reaction time. (C) 2020 Elsevier Ltd. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Nayak, SS; Wadhawa, GC; Shivankar, VS; Patil, DD; Sonawale, MC; Mirgane, NA or concate me.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about TETRAPROPYLAMMONIUM BROMIDE; BIOLOGICAL EVALUATION; DERIVATIVES; CATALYST; WATER, Saw an article supported by the Urmia University. HPLC of Formula: C9H7NO2. Published in WILEY in HOBOKEN ,Authors: Marjani, AP; Khalafy, J; Farajollahi, A. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

In this research, in order to synthesize a series of ethyl 2-amino-4-benzoyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates, a green and an efficient method is proposed through one-pot three-component reaction of substituted arylglyoxals, ethyl cyanoacetate, and 4-hydroxyquinolin-2(1H)-one in the presence of terapropylammonium bromide as a catalyst in good yields. All synthesized new substances were characterized by FTIR, H-1-NMR, and C-13-NMR spectral data and elemental analysis.

HPLC of Formula: C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Marjani, AP; Khalafy, J; Farajollahi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Sequential Energy Transfer Catalysis: A Cascade Synthesis of Angularly-Fused Dihydrocoumarins published in 2019. Safety of 3-(Trifluoromethyl)phenol, Reprint Addresses Gilmour, R (corresponding author), Westfalische Wilhelms Univ Munster, Inst Organ Chem, Corrensstr 40, D-48149 Munster, Germany.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

An operationally simple one-pot protocol has been developed to enable the conversion of diversely substituted cinnamic acid derivatives into angularly-fused dihydrocoumarins (up to 94%). Inspired by coumarin biosynthesis, this reaction cascade harnesses photochemical E -> Z alkene isomerization enabled by energy transfer catalysis using inexpensive thioxanthen-9-one (TX) under irradiation at 402 nm. Subsequent lactonization generates the heterocyclic core prior to a second photosensitization event to induce a [2 + 2] cycloaddition, again mediated by TX. The tetracyclic products are generated efficiently, and proof of the structure was established by X-ray crystallography. Mechanistic investigations, including structural probes and NMR reaction monitoring, support the postulated order of events. The study underscores the synthetic value of inexpensive small-molecule organic photocatalysts in the generation of structural complexity via sequential pi-bond activation.

Safety of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Nevesely, T; Daniliuc, CG; Gilmour, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 98-17-9. I found the field of Radiology, Nuclear Medicine & Medical Imaging very interesting. Saw the article Pulmonary Insufficiency Advantage of Pulmonary Regurgitation Volume Versus Pulmonary Regurgitation Fraction in a Congenital Heart Disease Mixed Population published in 2019, Reprint Addresses Ali, M (corresponding author), CDI, Unit Diagnost Imaging & Stereotact Radiosurg, Via St Bon 20, I-20147 Milan, Italy.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

Objective: The objective of this study was to compare the use of pulmonary regurgitation volume (PRV) or indexed PRV (PRVi) with that of pulmonary regurgitation fraction (PRF) in the assessment of patients with pulmonary regurgitation (PR) undergoing cardiac magnetic resonance (CMR) imaging. Materials and Methods: CMR of 176 patients with PR were retrospectively evaluated. Their right ventricular diastolic (end-diastolic volume index [EDVi]) and systolic (end-systolic volume index) volume indexes, stroke volume, and ejection fraction were obtained from cine CMR sequences, whereas phase-contrast flow sequences were analyzed to obtain PRV, PRVi, and PRF. Patients were divided into subgroups, according to underlying pathology and according to PR severity. Correlations between PRV or PRF and RV parameters were studied through Spearman rho, both in the main group and subgroups. Follow-up examinations were analyzed, and correlations between PRV or PRF from the first CMR examination and volume data from the second were calculated. Results: Tetralogy of Fallot was the main setting of PR (98/179). Overall, EDVi strongly correlates with PRV (rho=0.592, P<0.001) than with PRF (rho=0.522, P<0.001), and end-systolic volume index strongly correlates with PRV (rho=0.454, P<0.001) and PRF (rho=0.406, P <0.001). As regards subgroup analysis, in moderate or severe PR patients, EDVi strongly correlates (P=0.043) with PRV (rho=0.499, P<0.001) than with PRF (rho=0.317, P<0.001). Follow-up EDVi correlates with PRV (rho=0.450, P=0.031), but not with PRF. Conclusions: Especially when assessing moderate to severe PR, PRV and PRVi may be better indicators of right ventricular dysfunction than PRF. Moreover, PRV may be a predictor of worsening RV dilation. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Secchi, F; Chessa, M; Petrini, M; Monti, CB; Ali, M; Cannao, PM; Di Leo, G; Sardanelli, F or concate me.. Recommanded Product: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about WET AIR OXIDATION; ARYL-ALPHA-DIAZOACETATES; FENTON-LIKE DEGRADATION; SI-H; CARBENE INSERTION; NATURAL-PRODUCTS; DIAZO-COMPOUNDS; N-H; HYDROGEN-ATOM; M-CRESOL, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21901124]; Natural Science Foundation of the Jiangsu Higher Education Institutions of ChinaNational Natural Science Foundation of China (NSFC) [19KJB150032, 19KJB610013]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M651809]; Jiangsu Planned Projects for Postdoctoral Research Funds [2019K110]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20160989]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, ZP; Yu, Y; Huang, F; Yi, XY; Xu, Y; He, YD; Baell, JB; Huang, H. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Quality Control of 3-(Trifluoromethyl)phenol

Developing a greener, sustainable catalyst is a very important but challenging task in organic synthesis. Herein, for the first time, we choose more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perchloric acid as a new catalyst for carbene insertion of alpha-aryl alpha-diazoacetates into O-H bonds of phenols with good yields and high functional group tolerance. Significantly, we explored the scope of natural phenols with compelling biological activity, and successfully afforded the O-H insertion and meta C-H functionalization products. Their structures have been confirmed by single-crystal X-ray crystallography. Furthermore, the bioactivities (anti-tumor and anti-inflammatory) of the majority of O-H insertion products are better than those of the natural phenols themselves. The IC50 values indicated that the remarkable compounds 7a (IC50 = 16.80 mu M) and 7c (IC50 = 16.48 mu M) had better inhibition for tumor cell A-549 than positive control DDP (IC50 = 20.62 mu M). It should be noted that these transformations may provide a new strategy to derive natural products and discover new drugs.

Quality Control of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, ZP; Yu, Y; Huang, F; Yi, XY; Xu, Y; He, YD; Baell, JB; Huang, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Awasthi, A; Yadav, P; Tiwari, DK in ROYAL SOC CHEMISTRY published article about in [Awasthi, Annapurna; Yadav, Pushpendra; Tiwari, Dharmendra Kumar] Ctr Biomed Res CBMR, Mol Synth & Drug Discovery Unit, SGPGIMS Campus,Raibareli Rd, Lucknow 226014, Uttar Pradesh, India; [Awasthi, Annapurna; Yadav, Pushpendra] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 63.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available alpha-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This high-yielding reaction proceeds through a [3+2]-cycloaddition reaction between alkylidene pyrazolones and a nonstabilized azomethine ylide generated in situ. This method provides easy and smooth access to a variety of highly functionalized aza-spirocyclic pyrazolones in excellent yields (up to 96%). The obtained spiro-pyrazolones comprise four contiguous stereogenic centers including a quaternary carbon center.

Recommanded Product: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Awasthi, A; Yadav, P; Tiwari, DK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 86-95-3. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors published in 2019, Reprint Addresses Aly, AA (corresponding author), Menia Univ, Fac Sci, Dept Chem, Al Minya 61519, Egypt.; Abuo-Rahma, GEDA (corresponding author), Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt.. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one.

Two new series of diethyl 2-[2-(substituted-2-oxo-1,2-dihydroquinolin-4-yl)hydrazono]-succinates 6a-g and 1-(2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been designed and synthesized. The structures of the synthesized compounds were proved by IR, mass, NMR (2D) spectra and elemental analyses. The target compounds were evaluated for their in vitro cytotoxic activity against 60 cancer cell lines according to NCI protocol. Consequently, seven compounds were further examined against the most sensitive cell lines, leukemia CCRFCEM, and MOLT-4. 5-Amino-1-(6-bromo-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile (7f) was the most active product, with IC50= 1.35 uM and 2.42 uM against MOLT-4 and CCRF-CEM, respectively. Also, it showed a remarkable inhibitory activity compared to erlotinib on the EGFR TK with IC50 = 247.14 nM and 208.42 nM, respectively. Cell cycle analysis of MOLT-4 cells treated with 7f showed cell cycle arrest at G2/M phase (supported by Caspases, BAX and Bcl-2 studies) with a significant pro-apoptotic activity as indicated by annexin V-FITC staining. Moreover, the docking study indicated that both the pyrazole moiety and the quinolin-2-one ring showed good fitting into EGFR (PDB code: 1M17). In order to interpret SAR of the designed compounds, and provide a basis for further optimization, molecular docking of the synthesized compounds to known EGFR inhibitors was performed. The study illustrated the effect of several factors on the compounds’ activity.

Recommanded Product: 86-95-3. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Elbastawesy, MAI; Aly, AA; Ramadan, M; Elshaier, YAMM; Youssif, BGM; Brown, AB; Abuo-Rahma, GEDA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C9H10O3. In 2021.0 CHEM PAP published article about CRYSTAL-STRUCTURE; ORGANIC-CRYSTAL; Z-SCAN; GROWTH; ABSORPTION; STABILIZATION; MOLECULES in [Raghavendra, S.] Adichunchanagiri Inst Technol, Dept Engn Phys, Chikmagaluru 577102, India; [Kumar, C. S. Chidan] Visvesvaraya Technol Univ, Vidya Vikas Inst Engn & Technol, Dept Chem, Mysuru 570028, Karnataka, India; [Kumar, D. J. Madhu] Ramaiah Univ Appl Sci, Fac Pharm, Bengaluru 560054, India; [Al-Ghorbani, Mohammed] Thamar Univ, Dept Chem, Coll Educ, Thamar, Yemen; [Alsalme, Ali] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia; [Quah, C. K.] Univ Sains Malaysia, Xray Crystallog Unit, Sch Phys, Gelugor 11800, Penang, Malaysia; [Raghavendra, P. V.] SDM Coll Engn & Technol, Dept Phys, Dharwad 580002, Karnataka, India; [Serrao, Felcy Jyothi] Sahyadri Coll Engn & Management, Dept Engn Phys, Mangaluru 575007, India; [Dharmaprakash, S. M.] Mangalore Univ, Dept Studies Phys, Mangalagangothri 574199, India in 2021.0, Cited 52.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Herein, we report the third-order nonlinear absorption and optical limiting property of fluorinated polymorphic nonlinear optical (NLO) material 1-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl) prop-2-en-1-one (abbreviated as PDPFO) based on reverse saturable absorption. The FTIR studies of optically transparent PDPFO single crystals confirm the presence of various functional groups. PDPFO is optically transparent in the visible wavelength region. The open aperture Z-scan technique showed the intensity-dependent nonlinear absorption. A decrease in normalized transmittance with input intensity indicated the optical limiting behavior at the wavelength 532 nm. The excited-state absorption cross-section value (sigma(ex)= 1.72 x 10(-16) cm(2)) is much greater than ground-state absorption cross-section value (sigma(g)= 2.49 x 10(-22) cm(2)), suggesting that optical limiting phenomena are due to RSA.

Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Raghavendra, S; Kumar, CSC; Kumar, DJM; Al-Ghorbani, M; Alsalme, A; Quah, CK; Raghavendra, PV; Serrao, FJ; Dharmaprakash, SM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity WOS:000497964000013 published article about DERIVATIVES; NUCLEOSIDE; PHOSPHATE in [Kandil, Sahar; Chapman, Fiona M.; Westwell, Andrew D.; McGuigan, Christopher] Cardiff Univ, Sch Pharm & Pharmaceut Sci, King Edward VII Ave, Cardiff CF10 3NB, S Glam, Wales; [Pannecouque, Christophe] Katholieke Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, Minderbroedersstr 10, B-3000 Leuven, Belgium in 2019, Cited 17. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. HPLC of Formula: C7H5F3O

Human Immunodeficiency Virus (HIV) damages the immune system and leads to the life-threatening acquired immunodeficiency syndrome (AIDS). Despite the advances in the field of antiretroviral treatment, HIV remains a major public health challenge. Nucleosides represent a prominent chemotherapeutic class for treating viruses, however their cellular uptake, kinase-mediated activation and catabolism are limiting factors. Herein, we report the synthesis and in vitro evaluation of stavudine (d4T) ProTides containing polyfluorinated aryl groups against two strains; HIV-1 (IIIB) and HIV-2 (ROD). ProTide 5d containing a meta-substituted pentafluorosulfanyl (3-SF5) aryl group showed superior antiviral activity over the parent d4T and the nonfluorinated analogue 5a. ProTide 5d has low nano-molar antiviral activity; (IC50=30 nM, HIV-1) and (IC50=36 nM, HIV-2) which is over tenfold more potent than d4T. Interestingly, ProTide 5d showed a significantly high selectivity indices with SI=1753 (HIV-1) and 1461 (HIV-2) which is more than twice that of the d4T. All ProTides were screened in wild type as well as thymidine kinase deficient (TK-) cells. Enzymatic activation of ProTide 5d using carboxypeptidase Y enzyme and monitored using both P-31 and F-19 NMR is presented.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Kandil, S; Pannecouque, C; Chapman, FM; Westwell, AD; McGuigan, C or concate me.. HPLC of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about DERIVATIVES; INHIBITORS; FUROQUINOLINE; ALKALOIDS; MODEL, Saw an article supported by the . Computed Properties of C9H7NO2. Published in SPRINGER WIEN in WIEN ,Authors: Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH. The CAS is 86-95-3. Through research, I have a further understanding and discovery of 4-Hydroxyquinolin-2(1H)-one

Quinoline-2,4-diones reacted with 2-[bis(methylthio)methylene]malononitrile in DMF/Et3N to produce 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carbonitriles and 3-(methylthio)-4-oxo-4,5-dihydrofuro[3,2-c]quinolone-2-carboxamides in state of 2-imino-substituted 4-(methylthio)-5,6-dihydro-2H-pyrano[3,2-c]quinolone-3-carbonitriles. The structures of all new products were proved using NMR, IR, and mass spectral data. The possible mechanism for the reaction is also discussed. Graphic abstract

Computed Properties of C9H7NO2. About 4-Hydroxyquinolin-2(1H)-one, If you have any questions, you can contact Aly, AA; Ishak, E; Shwaky, AM; Mohamed, AH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles