Tag: M.W:200-300

137088-51-8, 1-(tert-Butoxycarbonyl)indoline-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 24.6 (950 mg, 3.61 mmol, 1 eq) in THF (15 mL) wasadded BH3-Me2S (10 M, 721.64 iL, 2 eq) at 0C. The mixture was stirred at 25C for 15hours. The reaction mixture was quenched by addition H20 30 mL at 25C and extracted with ethyl acetate (15 mL x 3). The combined organic layers were washed with saturated brines (5 mL x 1), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a crude product. Compound 24.5 (750 mg, 3.01 mmol, 83.34% yield) was

137088-51-8, 137088-51-8 1-(tert-Butoxycarbonyl)indoline-2-carboxylic acid 2794663, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; CORTEXYME, INC.; LYNCH, Casey C.; KONRADI, Andrei; GALEMMO, JR., Robert A.; (218 pag.)WO2018/209132; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

914348-94-0, tert-Butyl 3-formyl-5-methyl-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

914348-94-0, General procedure: To the stirred mixture of substituted indole (8(aec), 0.50 g,2.0 mmol) and substituted isoxazole amine (5(aee), 0.35 g,2.0 mmol) in methanol (5.0 ml) was added 4 A molecular sieves(0.50 g) and catalytic amount of acetic acid. The above reactionmixture was allowed to stir for 1 h at room temperature. followedby the portion wise addition of sodium cyanoborohydride (0.32 g,5.0 mmol) was added portionwise at room temperature and thereaction mixture was allowed to stir for 16 h. Solvent was removed under reduced pressure and then diluted with dichloromethane,which was washed with 10% sodium bicarbonate solution. Theobtained DCM layer was dried over sodium sulphate and distilledunder vacuum to obtain crude 9(aeo), which was further purifiedby column chromatography using ethyl acetate and hexane mixture(80:20) to obtain pure compounds in 80% yield.

The synthetic route of 914348-94-0 has been constantly updated, and we look forward to future research findings.

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Article; Pedada, Srinivasa Rao; Yarla, Nagendra Sastry; Tambade, Pawan J.; Dhananjaya, Bhadrapura Lakkappa; Bishayee, Anupam; Arunasree, Kalle M.; Philip, Gundala Harold; Dharmapuri, Gangappa; Aliev, Gjumrach; Putta, Swathi; Rangaiah, Gururaja; European Journal of Medicinal Chemistry; vol. 112; (2016); p. 289 – 297;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

90858-86-9, 4-Bromo-5-methoxy-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

90858-86-9, NaH (60percent in oil, 75.6 mg, 3.15 mmol) is added to a RT solution of 4-bromo-5-methoxy-1 H-indole (500 mg, 2.1 mmol) in DMF (5 mL). The RM is stirred at RT for 20 min and iodomethane (0.145 mL, 2.31 mmol) is added. The RM is then stirred overnight at RT. Water is added, and the mixture is extracted twice with EtOAc. Combined organic layers are washed with brine, dried (MgSC>4), filtered and concentrated under reduced pressure. The residue is purified by FC (heptane:EtOAc, 1 :0 to 7:3), affording the title compound as a beige solid (426 mg, 84percent). LC-MS B: tR = 0.94 min; [M+H]+ = 241.91.

The synthetic route of 90858-86-9 has been constantly updated, and we look forward to future research findings.

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Patent; IDORSIA PHARMACEUTICALS LTD; BOSS, Christoph; CORMINBOEUF, Olivier; FRETZ, Heinz; LYOTHIER, Isabelle; POZZI, Davide; RICHARD-BILDSTEIN, Sylvia; SIENDT, Herve; SIFFERLEN, Thierry; (160 pag.)WO2018/210992; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

15903-94-3, 6-(Benzyloxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Procedure F: Deprotection of the benzyloxy group and reduction of the alpha,beta- unsaturated system. Method I: To a solution of an alpha,beta-unsaturated ester/acid/amide or/and compounds protected with a benzyl group (6.72 mmol) in EtOH (50 mL) was added 10percent Pd/C (0.16 g) and HC02NH4 (67 mmol). The mixture was refluxed for 1 h. The catalyst was removed by filtration through celite and concentrated to give the product.6-Hydroxyindole. 6-Hydroxyindole was prepared from 6-benzyloxyindole by procedure F (Methods I or II), was isolated by chromatography eluted with EtOAc- hexane (1 : 1) to give white solid in 66percent yield, mp 123- 125 ¡ãC [128-129 ¡ãC]. 1H-NMR (300 MHz, CDCI3) ppm delta 8.51 (bs, 1H, H-1), 7.41 (d, J = 8.8 Etazeta, IotaEta, H-4), 6.94 (t, J = 2.9 Hz, 1H, H-2), 6.80 (d, J = 2.2 Hz, 1H, H-7), 6.71 (dd, J = 8.8, 2.2 Hz, 1H, H-5), 6.38 (ddd, J = 2.9, 1.5, 0.7 Hz, 1H, H-3); 13C-NMR (75 MHz, CDC13) ppm delta 152.19, 136.78, 123.09, 121.90, 120.87, 109.76 (C-7)., 15903-94-3

15903-94-3 6-(Benzyloxy)-1H-indole 260804, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD; BAR ILAN UNIVERSITY; NUDELMAN, Abraham; WEINSTOCK-ROSIN, Marta; WO2013/150529; (2013); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

475102-10-4, tert-Butyl 5-cyano-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The indole derivative in the THF is introduced into a 50 ml round-bottomed flask. The borate is added at room temperature under nitrogen, followed by dropwise addition over 20 minutes, at 0 C. under nitrogen, of the LDA. The mixture is stirred at 0 C. for 2 hours. The reaction medium is neutralized with 2N HCl and extracted with EtOAc. After drying and evaporating off the solvent, 829.3 mg of a brown foam containing 60% of the expected product, N-Boc-5-cyanoindole-2-boronic acid, and 40% of its Boc-free analogue, are obtained. This product is used without further purification for the coupling in Step 3.

475102-10-4, As the paragraph descriping shows that 475102-10-4 is playing an increasingly important role.

Reference£º
Patent; Aventis Pharma S.A.; US2004/242559; (2004); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83515-06-4,5-Bromo-2-phenyl-1H-indole,as a common compound, the synthetic route is as follows.

83515-06-4, A stream of nitrogen under 2-nitrophenylboronic acid (11.04 g, 66.14 mmol) and the preparation example 18 of In the obtained 5-bromo-2-phenyl-1H-indole (15 g, 55.12 mmol), NaOH (6.61 g, a mixture of 165.36 mmol) and THF / H2O (200 ml / 100 ml), and then insert the Pd (PPh3) 4 (3.18 g, 5 mol) in 40 , was stirred for 12 hours at 80 .After completion of the reaction, extracted with methylene chloride, and then filtered into a MgSO4. After removal of the solvent in the resulting organic layerColumn chromatography (Hexane: EA = 5: 1 (v / v)) to give 5- (2-nitrophenyl) -2-phenyl-1H-indole to obtain a (10.74 g, yield 62%). 1H-NMR: delta 6.88 (dd, 1H), 7.21 (d, 1H), 7.32 (m, 1H), 7.34 (d, 1H), 7.46 (m, 3H), [0382] 7.64 (m, 2H), 7.77(d, 2H), 8.02 (d, 2H), 11.73 (s, 1H).

83515-06-4 5-Bromo-2-phenyl-1H-indole 838923, aindole-building-block compound, is more and more widely used in various fields.

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Patent; Doosan Co. Ltd.; Lee, Young Hwan; Kim, Tae Hyoung; Son, Hyo? Seok; Bae, Hyeong Chan; Park, Ho Cheol; Lee, Chang Jun; Shin, Jin Young; Baek, Young Mi; (97 pag.)KR101571589; (2015); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1092114-59-4,3-Iodo-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

1092114-59-4, General procedure: To a 5 mL round bottom flask containing 0.1 g of 3-iodoindole was added 2.0 mL of DMSO followed by NIS (10 mol%) and IBX (3.0 equiv). The resultant reaction mixture was stirred at 30 ¡À 5 C. After completion of the reaction as monitored by TLC analysis, the product was isolated following the work-up procedure described above.

As the paragraph descriping shows that 1092114-59-4 is playing an increasingly important role.

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Article; Chandra, Ajeet; Yadav, Navin R.; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 75; 14; (2019); p. 2169 – 2174;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

143612-79-7, 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15 A solution of 10.8 g of 3-[4-(N,N-bis(2-chloroethyl)amino)butyl]-5-cyanoindole (“E”) [obtainable by reaction of 3-(4-chlorobutyl)-5-cyanoindole with N,N-bis(2-chloroethyl)amine] and one equivalent of p-methoxyaniline in 200 ml of acetonitrile is stirred for 12 hours at room temperature and worked up in a conventional manner, and 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole, m.p. 207 (dec.), is obtained., 143612-79-7

The synthetic route of 143612-79-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Patent Gesellschaft mit Beschrankter Haftung; US5418237; (1995); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

115666-47-2, 6-Iodo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Iodo-1H-indole (100 mg, 0.41 mmol,1.00 equiv) was dissolved in dry THF (10 mL) under N2 and cooled to -78 C. At thistemperature a 1.0 M solution of LHMDS in THF (450 muL, 0.45 mmol, 1.10 equiv) was addedand the reaction was stirred for 30 min before TIPSCl (95 muL, 0.43 mmol, 1.05 equiv) wasadded. After stirring for 20 min at -78 C and 1 h at room temperature the reaction wasquenched with saturated NH4Cl (1 mL). Water (5 mL) was added and the reaction mixturewas extracted with EtOAc (3 x 10 mL), dried, filtered and concentrated. Flash columnchromatography on silica gel using petroleum ether, primed with petroleum ether/NEt3(100:1) as the eluent afforded the product as colorless oil (152 mg, 0.38 mmol, 93%)., 115666-47-2

As the paragraph descriping shows that 115666-47-2 is playing an increasingly important role.

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Article; Marsch, Nils; Kock, Mario; Lindel, Thomas; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 334 – 342;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

24985-85-1, Ethyl 5-hydroxyindole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 5-hydroxy-lH-indole-2-carboxylate (250 mg, 1.218 mmol) in N-methyl-2- pyrrolidone (NMP) (2.0 mL) was added benzyl 3,5-dichloro-4-fluorobenzoate (364 mg, 1.218 mmol) followed by DIPEA (1.064 mL, 6.09 mmol) and the mixture was heated in a microwave reactor 200 C 30 min very high then 200 C 6 h very high abs. The crude reaction mixture was partitioned between ether and 1.0 M NaOH, washed with water, dried over magnesium sulfate, and concentrated in vacuo. The evaporation residue was subjected to normal phase purification (0-20 %EtOAc/hexanes) to afford ethyl 5-(4-((benzyloxy)carbonyl)-2,6-dichlorophenoxy)-lH-indole-2- carboxylate (234 mg, 0.483 mmol, 39.7 % yield) as a pale brown solid.1H NMR (400 MHz, CHLOROFORM-i ? ppm 9.28 (br. s., 1 H), 8.13 (s, 2 H), 7.37 – 7.50 (m, 6 H), 7.06 – 7.11 (m, 2 H), 6.91 (d, .7=2.45 Hz, 1 H), 5.41 (s, 2 H), 4.43 (q, .7=7.09 Hz, 2 H), 1.42 (t, .7=7.09 Hz, 3 H). LCMS (2 min TFA): Rt = 1.56 min, [M+H]+= 484.0., 24985-85-1

The synthetic route of 24985-85-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BAILEY, James; CHEN, Yao; HURLE, Mark; LEACH, Craig; TURUNEN, Brandon; (103 pag.)WO2018/134731; (2018); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles