Tag: M.W:200-300

16732-70-0, Ethyl 5-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

16732-70-0, Cu(N03)2 was added to acetic anhydride (10 mL) at -5C (whilst stirring the mixture). After 10 min, a solution of 5-bromo-IH-indole-2-carboxylic acid ethyl ester (2.0 g, 7.46 nunol) in acetic anhydride (25 mL) was added portion-wise. The mixture was stirred for 2 h at-5C, solid was removed by filtration and washed with acetic anhydride. The filtrate was poured into ice-water (150 mL) and stirred for 5 h. The precipitate was filtered, washed with water and dried to afford the sub-title compound (2.2 g, 94%).

As the paragraph descriping shows that 16732-70-0 is playing an increasingly important role.

Reference£º
Patent; BIOLIPOX AB; WO2005/123674; (2005); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

467451-91-8, 6-(Trifluoromethoxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,467451-91-8

Oxalyl chloride (0.19 ml, 2.2 mmol, 1.1 eq) was added to (4) (0.40 g, 2.0 mmol, 1.0 eq) in Et2O (5 ml) at O0C. The reaction was allowed to reach room temperature and stirred for 4 h after which time the product was isolated by filtration. The filtrate was evaporated to give further product. The product was washed with Et2O (2 x 10ml) to provide (5) as a yellow solid (0.58 mg, 2.0 mmol, 100%).

467451-91-8 6-(Trifluoromethoxy)-1H-indole 22048958, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; LECTUS THERAPEUTICS LIMITED; KHAN, Nawaz Mohammed; BURCKHARDT, Svenja; CANSFIELD, Julie Elaine; VO, Ngoc-Tri; ARMER, Richard Edward; BOFFEY, Raymond John; WO2010/1179; (2010); A2;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20289-26-3,4-Benzyloxyindole,as a common compound, the synthetic route is as follows.

EXAMPLE 17; 2-Amino-4-(3-bromo-4,5-dimethoxyphenyl)-3-cyano-7-hydroxymethyl-4H-pyrrolo[2,3-h]chromene; a) 1-Hydroxymethyl-4-hydroxy-indole:; A solution of 4-benzyloxyindole (1.0 g, 4.48 mmol), formaldehyde (2.0 mL, 26.8 mmol) and 2 N NaOH (2.24 mL, 4.48 mmol) in 10 mL EtOH was stirred at the room temperature for 4 h. The solvent was removed in vacuo. The crude material was purified by flash column chromatography (3:1, hexane:ethyl acetate) to yield 1.13 g of 4-benzyloxy-1-hydroxymethylindole, which was hydrogenated by 5% Pd/C in 40 mL methanol under H2 (50 psi) to yield 580 mg (79.5%) of the title compound. 1H NMR (CDCl3): 7.15-7.07 (m, 3H), 6.60-6.55 (m, 2H), 5.62 (d, J=7.5 Hz, 2H), 4.93 (s, 1H), 2.37 (t, J=7.2 Hz, 1H).

20289-26-3, The synthetic route of 20289-26-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Cytovia, Inc.; US2006/104998; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91348-45-7,Ethyl 3-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

91348-45-7, Intermediate 22a : Ethyl 3-bromo-1 -{[4′-(methoxycarbonyl)-4- methylbiphenyl-3-yl]methyl}-1 H-indole-2-carboxylateTo 68.3 g (0.266 mol) of methyl 3′-(hydroxymethyl)-4′-methylbiphenyl- 4-carboxylate in 1.0 L EtOAc was added at 100C 20.5 ml_ (0.280 mol) SOCI2 and 1 ml_ pyridine. The solution was then stirred at room temperature for 12 hrs then washed with 500 ml_ 1.0 N HCI (aq), 500 ml_ sat. NaHCO3 (aq) and 500 ml_ brine then dried over Na2SO4 and concentrated. To 750 mg (2.71 mmol) of this residue was added 660mg (2.46 mmol) of ethyl 3-bromo-1 H- indole-2-carboxylate in 8 ml_ DMF followed by 850 mg (6.16 mmol) K2CO3 and the mixture stirred at 7O0C for 4 hrs. The solution was cooled and 100 ml_ EtOAc was added. The solution was washed with three 25 ml_ portions of H2O and 25 ml_ brine then dried over Na2SO4, concentrated, and purified by silica gel chromatography (120 grams of silica gel eluting with 0-20% EtOAc in hexanes over 45 minutes) to give 1.02 g (82%) of ethyl 3-bromo-1 -{[4′- (methoxycarbonyl)-4-methylbiphenyl-3-yl]methyl}-1H-indole-2-carboxylate as white solid: 1 H NMR (400 MHz, CDCI3). delta 7.93 (d, 2H, J = 8.5 Hz), 7.74 (d, 1 H, J = 7.9 Hz), 7.40-7.22 (m, 7H), 6.54 (s, 1 H), 5.79 (s, 2H), 4.34 (q, 2H, J = 7.4 Hz), 3.87 (s, 3H), 2.46 (s, 3H), 1.32 (t, 3H, J = 7.4 Hz)

As the paragraph descriping shows that 91348-45-7 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORAITON; OPLINGER, Jeffrey Alan; WO2008/28118; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,942-26-7

General procedure: A flask was charged with 5-chlorotryptamine hydrochloride (5 g, 0.0649 mol), 0.5 M hydrochloric acid(130 mL), and the substituted benzaldehyde (1.5 eq). The mixture was refluxed for 14 hr, cooled to roomtemperature, and vacuum filtered. The solid was resuspended in acetic acid (100 mL), stirred for 1 hr, andvacuum filtered. The solid was resuspended in ethyl acetate (100 mL), stirred for 1 hr, and vacuumfiltered to obtain the pure scaffold as a solid.

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

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Article; Tikhmyanova, Nadezhda; Paparoidamis, Nicholas; Romero-Masters; Feng, Xin; Mohammed, Farheen Sultana; Reddy, Poli Adi Narayana; Kenney, Shannon C.; Lieberman, Paul M.; Salvino, Joseph M.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2259 – 2264;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

16732-57-3, Ethyl 5-nitro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLES Intermediate 1 5-Amino-1H-indole-2-carboxylic acid ethyl ester A solution of 5.1 g (22 mmol) ethyl 5-nitro-2-carboxylate indole in 300 ml THF was hydrogenated over PtO2 with 1 bar H2 for 2 h at room temperature. After filtration and evaporation the residue was purified over silica eluting with a mixture of ethyl acetate/heptane 4/1. After evaporation of the product fractions 4.28 g (96%) of the title compound was yielded as brown solid. MS (m/e): 205.3 (MH+, 100%)., 16732-57-3

The synthetic route of 16732-57-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nettekoven, Matthias Heinrich; Plancher, Jean-Marc; Roche, Olivier; Rodriguez-Sarmiento, Rosa Maria; US2006/160855; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

197506-83-5, Methyl 3-formyl-1H-indole-5-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of the methyl 3-formyl-1H-indole-5-carboxylate (893 mg, 4.4 mmol) in DMF (20 mL) was added the p-toluenesulfonic acid monohydrate (125 mg, 0.7 mmol) and the p-toluenesulfonyl hydrazide (982 mg, 5.3 mmol). The solution has been heated for 20 min at 100 C. The resulting mixture was diluted with ethyl acetate, washed with brine, dried over MgSO4 and concentrated. The crude product is dissolved in THF (40 mL) and NaBH3 CN (1.1 g, 17.6 mmol) was added. The solution has been heated for 8 h at 75 C. The resulting mixture was diluted with ethyl acetate, washed with a solution of 0.5 N HCl, a saturated solution of NaHCO3 and brine, dried over MgSO4 and concentrated. The crude product was purified by flash chromatography (Hexane/AcOEt, from 0 to 30%) to yield a white powder (500 mg, 2.6 mmol, 60%). ESI-MS (m/z): 190 [M+H]+.

197506-83-5, 197506-83-5 Methyl 3-formyl-1H-indole-5-carboxylate 19606277, aindole-building-block compound, is more and more widely used in various fields.

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Patent; SCRIPPS RESEARCH INSTITUTE, THE; US2012/309757; (2012); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

914349-07-8,914349-07-8, tert-Butyl 3-(hydroxymethyl)-5-nitro-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4 (2.78 g, 9.5 mmol) was added to 40 ml of DCM, and then at 0 C., thionyl chloride (2.75 ml, 37.8 mmol) was added to the above reaction solution, and the reaction solution was moved to room temperature to react 1.5. h. The reaction mixture was quenched with water and extracted with DCM (X 3), dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and separated on a silica gel column (PE: EA = 4:1) to give 2.0 g of a white solid. Yield 67%, purity 95.7%

As the paragraph descriping shows that 914349-07-8 is playing an increasingly important role.

Reference£º
Patent; Xihua University; Yang Lingling; Yan Jie; Su Huilin; Wang Zhouyu; Qian Shan; Wang Lijiao; (22 pag.)CN107915726; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165669-07-8,7-Bromo-4-methyl-1H-indole,as a common compound, the synthetic route is as follows.

To a mixture of potassium hydride (4.47 g, 34.27 mmol, 30 wt %) suspended in anhydrous tetrahydrofuran (80 mL) was added 7-bromo-4-methyl-1H-indole (6.00 g, 28.56 mmol) dissolved in tetrahydrofuran (30 mL) at 0 C. After 15 minutes, the mixture was cooled to -70 C. and t-BuLi (1.3 M, 54.9 mL) was added dropwise, keeping the temperature below -65 C. After further 15 minutes, carbon dioxide gas (15 psi pressure) was bubbled into the reaction and the reaction was slowly warmed to rt over 30 minutes. On completion, the reaction mixture was quenched with ice water (120 mL), and washed with ethyl acetate (3¡Á60 mL). The aqueous phase was collected and acidified with 1 N hydrochloride acid solution until the pH<7. Then, the mixture was extracted with ethyl acetate (3¡Á60 mL). The organic phase was collected, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the crude product as a brown solid. The crude product was triturated with petroleum ether:dichloromethane (10:1, 100 mL) to give the product (3.50 g, 69% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 12.82 (br s, 1H), 11.02 (br s, 1H), 7.67 (d, J=7.6 Hz, 1H), 7.35 (t, J=2.8 Hz, 1H), 6.92 (d, J=7.6 Hz, 1H), 6.56 (dd, J=2.0, 3.2 Hz, 1H), 2.54 (s, 3H)., 165669-07-8

The synthetic route of 165669-07-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

10102-94-0, 5-Bromo-1-methyl-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 5-Nitro-1H-indazole-3-carbohydrazide (8, 500 mg,2.26 mmol, 1.0 eq.) was dissolved in 3 cm3 glacial acetic acid. To this reaction mixture 2.26 mmol indole-3-aldehyde(1.0 eq.) was added and heated at 90 C for 6 h. Later the reaction mass was neutralized with a cold NaHCO3 solution, filtered, and recrystallized from ethanol to afford 10a., 10102-94-0

As the paragraph descriping shows that 10102-94-0 is playing an increasingly important role.

Reference£º
Article; Sreenivasulu, Reddymasu; Sujitha, Pombala; Jadav, Surender Singh; Ahsan, Mohamed Jawed; Kumar, C. Ganesh; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 148; 2; (2017); p. 305 – 314;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles