Tag: M.W:200-300

436091-59-7,436091-59-7, 4-Bromo-7-methoxy-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 4-bromo-7-methoxyindole (5g, 22.2 mmol) in 1 ,4-dioxane (170 mL) were added bis(pinacolato)diboron (6.2 g, 24.4 mmol), KOAc (6.5 g, 66.3 mmol) and Pd(dppf)CI2 (1.2 g, 1.7 mmol) and the mixture was heated to reflux for 15 hrs. After cooling the mixture was concentrated and the residue was purified by Preparative TLC (PE/EtOAc= 20/1) to give the title compound (2.6 g, 43%). 1H NMR CDCI3400 MHz delta: 8.38 (brs, 1H), 7.60 (d, 1 H), 7.21 (d, 1 H), 7.01 (d, 1 H), 6.66 (d, 1 H), 3.98 (s, 3H), 1.39 (s, 12H).

The synthetic route of 436091-59-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SAREUM LIMITED; READER, John Charles; WO2013/117522; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133831-28-4,Methyl 3-Formylindole-6-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 2a(100 mg, 0.49 mmol) in dry DMF (2 ml) was added NaH (60%, 22 mg,0.54 mmol) at 0 C under argon and then stirred at room temperature for 1 h.The reaction solution was cooled to 0 C, benzoyl chloride (0.07 ml,0.54 mmol) was added and then stirred at room temperature overnight. The reaction solution was poured into H2O (20 ml), and the precipitate was filtered.The crude product was purified by column chromatography on silica gel using EtOAc/PE (1/8, V/V) as elute to give 6a as a white solid (107 mg, 71%),, 133831-28-4

The synthetic route of 133831-28-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hong, Wei; Li, Jingyang; Chang, Zhe; Tan, Xiaoli; Yang, Hao; Ouyang, Yifan; Yang, Yanhui; Kaur, Sargit; Paterson, Ian C; Ngeow, Yun Fong; Wang, Hao; Journal of Antibiotics; vol. 70; 7; (2017); p. 832 – 844;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

107516-75-6, Diethyl 1H-indole-2,6-dicarboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b: 1-(Cyano-methyl-methyl)-1H-indole-2,6-dicarboxylic acid diethyl ester A mixture of K2CO3 (7.93 g, 57.0 mmol) and 1H-indole-2,6-dicarboxylic acid diethyl ester (5.0 g, 19.14 mmol) in DMF (30 mL) was stirred at room temperature for 0.5 h. Then 2-bromo-propionitrile (3.4 mL, 38.3 mmol) in DMF (10 mL) was added. The reaction was warmed to 80 C. and kept at this temperature for 6 h. Then the reaction was cooled down to the room temperature. Most of the DMF solvent was removed in vacuo and the crude residue was extracted several times with EtOAc. The combined organic extracts were washed with brine, dried over MgSO4 and concentrated. The crude product was triturated with MeCN to give 3.9 g of 1-(cyano-methyl-methyl)-1H-indole-2,6-dicarboxylic acid diethyl ester as a white fluffy solid. The filtrate was concentrated and purification by silica gel chromatography provided 1.6 g of 1-(cyano-methyl-methyl)-1H-indole-2,6-dicarboxylic acid diethyl ester, yield 91%., 107516-75-6

The synthetic route of 107516-75-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US2006/276453; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

26807-73-8, 1-Benzyl-1H-indol-5-amine is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-benzyl-1H-indole-5-amine (250 mg, 1.12 mmol, 1.0 equiv.), k2CO3 (186 mg, 1.34 mmol,1.2equiv.) Dissolved in anhydrous CH3CN, the new 2,5-dichlorobenzoyl chloride (271mg, 1.29mmol, 1.15equiv.) was soluble.The anhydrous DCM was slowly added dropwise at 0 C and stirred under nitrogen for 2 hours. The TLC monitors the reaction in real time. After the reaction, diluted with water, the right amountEthyl acetate extraction three times, the organic phase is combined, washed with water, saturated NaHCO3 solution, saturated NaCl solution, organic layerDrying with anhydrous NaSO4, distilling under reduced pressure to give a crude product, which was purified by silica gel column to afford N-(1-benzyl-1H-indol-5-yl)-2,5-dichlorobenzamide (400 mg, yield: 89 %).

26807-73-8, The synthetic route of 26807-73-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Fudan University; Wang Yonghui; Yu Fazhi; Li Wei; (38 pag.)CN109232358; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-36-7,Ethyl 5-fluoro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of ethyl 5-fluoro-2-indole,Diphenylphosphine oxide as a raw material,The reaction steps are as follows:To the reaction flask was added 0.102 g (0.5 mmol) of ethyl 5-fluoro-2-indole ethyl ester,Diphenylphosphine oxide 0.152(0.75 mmol), 0.201 g (0.75 mmol) of manganese acetate and 30 ml of acetic acid at 50 ¡ã C for 1 hour. After the reaction,The crude product was separated by column chromatography (petroleum ether: ethyl acetate = 4: 1) to give the title product (yield 91percent

348-36-7, 348-36-7 Ethyl 5-fluoro-1H-indole-2-carboxylate 2727899, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Soochow University (Suzhou); Zou Jianping; Xue Jianfei; Zhou Shaofang; Zhang Peizhi; (12 pag.)CN105037422; (2017); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20289-26-3,4-Benzyloxyindole,as a common compound, the synthetic route is as follows.

7.0 g 4-benzyloxy-lH- indole (31.35 mmol) was dissolved in 60 mL dry DMF and 1.317 g NaH (32.92 mmol, 60 % on mineral oil) was added at 0 C. The mixture was stirred for 1 hour, then 6.09 g benzenesulfonyl chloride (34.48 mmol) was added dropwise and the mixture was stirred at 0 C until no further conversion was observed. Then it was diluted with water and extracted with DCM. The combined organic phases were dried over Na2S04, filtered and the filtrate was concentrated under reduced pressure and purified via flash chromatography using heptane and EtOAc as eluents to obtain l-(benzenesulfonyl)- 4-benzyloxy- indole. 1H NMR (400 MHz, DMSO-d6) delta: 7.97 (d, 2H), 7.72 (d, 1H), 7.69 (t, 1H), 7.59 (t, 2H), 7.54 (d, 1H), 7.47 (d, 2H), 7.39 (t, 2H), 7.33 (d, 1H), 7.27 (t,lH), 6.89 (d, 1H), 6.85 (d, 1H), 5.20 (s, 2H) MS (EI, 70 eV) m/z (% relative intensity, [ion]): 77 (32), 91 (100), 141 (18), 222 (6), 272 (11), 363 (10, [M+]), 20289-26-3

As the paragraph descriping shows that 20289-26-3 is playing an increasingly important role.

Reference£º
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; BALINT, Balazs; CSEKEI, Marton; SZABO, Zoltan; SZLAVIK, Zoltan; KOTSCHY, Andras; CHANRION, Maia; GENESTE, Olivier; CHEN, I-Jen; DAVIDSON, James Edward Paul; MURRAY, James Brooke; SIPOS, Szabolcs; ONDI, Levente; PROSZENYAK, Agnes; (164 pag.)WO2016/207217; (2016); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.166104-20-7,1-Boc-5-Aminoindole,as a common compound, the synthetic route is as follows.

Example 1; (A) A solution of the N-Boc protected amine (1 mmol) in TFE (2,2,2-trifluoroethanol) or HFIP (hexafluoroisopropanol) (5 mL) was placed in a sealed microwave vial. The reaction mixture was heated (100¡ãC or 150¡ãC) in a Biotage – Initiator.(TM). Sixty microwave reactor with stirring until the disappearance of the starting material was observed. After cooling to room temperature, the mixture was evaporated to dryness under reduced pressure. The crude product was purified by flash-column chromatography. 1H NMR and 13C NMR were measured on Bruker Avance DPX-300 NMR or Bruker Avance-300 NMR spectrometers, operating at a proton (1H) frequency of 300.13 MHz and carbon (13C) frequency of 75.43 MHz.Example 2 Following the procedure set forth in Example 1(A) above, indole derivatives were deprotected using TFE or HFIP in a microwave reactor at 150¡ãC as set forth in Table 1 below.

166104-20-7, 166104-20-7 1-Boc-5-Aminoindole 11593831, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; F. Hoffmann-La Roche AG; EP2070899; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

91348-45-7, Ethyl 3-bromo-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

91348-45-7, EXAMPLE 5OB ethyl 3-ortho-tolyl-lH-indole-2-carboxylateA mixture of EXAMPLE 31B (1.08 g), ortho-tolylboronic acid (1.1 g), (1,1′- bis(diphenylphosphino)ferrocene)dichloropalladium(II) (140 mg) in dimethoxyethane:2N aqueous Na2CO3 (25 mL:5 mL) was stirred under nitrogen at 😯 C for 16 hours, diluted with ethyl acetate and was washed with water and brine. The organic phase was dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash chromatography on silica gel with 0-10% ethyl acetate/hexanes.

The synthetic route of 91348-45-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ABBOTT LABORATORIES; WO2008/130970; (2008); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4792-58-9,Ethyl5-methoxyindole-2-carboxylate,as a common compound, the synthetic route is as follows.

i Ethyl 5-hydroxyindole-2-carboxylate Boron tribromide (64.58 g) was added dropwise to a stirred solution of ethyl 5-methoxyindole-2-carboxylate (20 g) in dichloromethane (1000 ml) at -78¡ã C. under an atmosphere of argon. The reaction was allowed to warm to room temperature and stirred for a further 2 hours. The reaction was poured into ice/saturated aqueous sodium hydrogen carbonate solution with stirring and extracted with ethyl acetate. Combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate solution, water, aqueous saturated sodium chloride solution and dried. The solution was concentrated in vacuo and the residue was purified by column chromatography using 0-60percent diethyl ether: iso-hexane as eluent to yield product as a white solid (9.02 g, 48percent). NMR(CD3SOCD3): delta 1.31 (t, 3H), 4.29 (q, 2H), 6.79 (dd, 1H), 6.90 (dd, 1H), 7.22 (d, 1H), 8.84 (s, 1H), 11.52 (brs, 1H); m/z 206 (MH+)., 4792-58-9

The synthetic route of 4792-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Faull, Alan Wellington; Kettle, Jason Grant; US2003/144339; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

1111638-02-8, 5-Bromo-2-methyl-7-azaindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 3.18 g (30.0 mmol) of sodium carbonate in 15 ml of water is added to a solution, kept under nitrogen, of 2.11 g (10.0 mmol) of 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine and 3.54 g (17.0 mmol) of pinacolyl 1-methyl-1H-pyrazole-4-boronate in 30 ml of DMF. The mixture is heated to 80 C., 462 mg (0.40 mmol) of tetrakis(triphenylphosphine)palladium are added, and the mixture is stirred at 80 C. for 18 hours. The reaction mixture is cooled to room temperature, and 50 ml of water are added. The precipitate formed is filtered off with suction, washed with water and dried in vacuo: 2-methyl-5-(1-methylpyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridine as grey solid; HPLC/MS (A): 1.68 min, [M+H] 213., 1111638-02-8

As the paragraph descriping shows that 1111638-02-8 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENT GMBH; Dorsch, Dieter; Hoelzemann, Guenter; Eggenweiler, Hans-Michael; Czodrowski, Paul; US2014/323481; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles