Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.43142-64-9,Ethyl 7-chloro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

The ester was treated with 1 M lithium hydroxide in ethanol (5 mL) followed by water (3 mL) and stirred at ambient temperature for 18 h. The solution was acidified with 10% hydrochloric acid, diluted with water and extracted with ethyl acetate. The organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated to afford give 7-Chloro-1H-indole-2-carboxylic acid (0.089 9).

43142-64-9, The synthetic route of 43142-64-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Carruthers, Nicholas I.; Chai, Wenying; Dvorak, Curt A.; Edwards, James P.; Grice, Cheryl A.; Jablonowski, Jill A.; Karlsson, Lars; Khatuya, Haripada; Kreisberg, Jennifer D.; Kwok, Annette K.; Lovenberg, Timothy W.; Ly, Kiev S.; Pio, Barbara; Shah, Chandravadan R.; Sun, Siquan; Thurmond, Robin L.; Wei, Jianmei; Xiao, Wei; US2003/207893; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

129822-45-3, tert-Butyl 4-fluoro-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of diisopropylamine (175 mL, 1.25 mol) in THF (800 mL) at 0 Cwas added n-BuLi (500 mL, 1.25 mol, 2.5 Min hexane) dropwise. The mixture was stirred at 0C for 40 min. Then the mixture was cooled to -78 C. Tert-butyl 4-fluoro-1H-indole-1-carboxylate (118 g, 0.50 mol) in THF (300 mL) was added dropwise slowly, followed by5 triisopropyl borate (231 mL, 1. 00 mol). The mixture was stirred at -78 C for another 40 min.The reaction was monitored by HPLC. When the reaction was completed, the reaction wasquenched with NH4Cl (sat. 500 mL). Then the mixture was adjusted to pH= 6 with 1 N HCl.Extracted with EtOAc (2000 mL) and the combined organic layers were washed with brine (500mL), dried over Na2S04, filtered and concentrated. The obtained solid was recrystallized with10 EtOAc and PE to give (1-(tert-butoxycarbonyl)-4-fluoro-1H-indol-2-yl)boronic acid (93 g, yield:64%, store in fridge). 1H-NMR (CDCh, 400 MHz) 8 7.77 (d, J = 8.4 Hz, 1H), 7.57 (s, 1H), 7.44(s, 2H), 7.24 (m, 1H), 6.90 (m, 1H), 1.66 (s, 9H). MS (M+Ht: 280.

129822-45-3, 129822-45-3 tert-Butyl 4-fluoro-1H-indole-1-carboxylate 14710388, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; BROCKUNIER, Linda L.; NARGUND, Ravi; MARCANTONIO, Karen; ZORN, Nicolas; XIAO, Dong; PENG, Xuanjia; LI, Peng; GUO, Tao; WO2014/121416; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

105191-12-6, 6-Bromo-1H-indole-2-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 150mL equipped with a magnetic stirrerIn a round bottom flask, 6-bromo-1H-indole-2-carbaldehyde (Compound 1) (8.07 g, 36.00 mmol), 4-methyl-3-oxopentanoate (Compound 2) (5.70 g) , 36.03 mmol), isopropanol (21.1 mL), piperidine (2.2 mL) and glacial acetic acid (1.2 mL). The reaction mixture was stirred at room temperature under nitrogen for 12 h.The solvent was removed under reduced pressure. The residue was taken in dichloromethane (13.88 mL)Dissolve and wash with saturated NaHCO3 (3*30 mL) solution. After drying over anhydrous MgSO4, MgSO4 was removed by filtration. After concentrating the solvent under reduced pressure, the column was separated by flash column chromatography. Obtained an off-white solid (Z)-2-((6-bromo-1H-indol-2-yl)methylene)-4-methyl-3-oxopentanoate (Compound 3), 12.46 g The yield is 95%.

105191-12-6, As the paragraph descriping shows that 105191-12-6 is playing an increasingly important role.

Reference£º
Patent; Meng Xiaoxu; (12 pag.)CN108689989; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18372-22-0,Methyl 2-(1H-indol-3-yl)-2-oxoacetate,as a common compound, the synthetic route is as follows.

In a three-necked flask, 47 mL lithium aluminum hydride (4.44 g, 117 mmol, 2.5 mol/L THF solution) was injected under Nitrogen at 0 C. 10.15 g (50 mmol) 1 was dissolved in 36 mL of dry THF. The above solution was added dropwise for a period of 1 h, then heated to 70 C for 4 hours. The reaction was complete and quenched by the Fisher treatment for a suspension. The suspension was filtered and the filter cake washed with ethyl acetate. The combined organic layer was wash with brine, dry over Na2SO4 and concentrated in vacuum. The residue was purified by flash silica gel column chromatography(ethyl acetate / petroleum ether, 25%) to obtain a white solid 2 (6.44 g, 80% yield)., 18372-22-0

The synthetic route of 18372-22-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Guo, Zhenbo; Xu, Yiming; Peng, Yujie; Haroon ur Rashid; Quan, Wei; Xie, Peng; Wu, Lichuan; Jiang, Jun; Wang, Lisheng; Liu, Xu; Bioorganic and Medicinal Chemistry Letters; vol. 29; 9; (2019); p. 1133 – 1137;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

16732-80-2, Ethyl 4-methyl-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

d) Synthesis of ethyl 1-[(2-ethoxycarbonylmethoxy)ethyl]-4-methyl-1H-indole-2-carboxylate A solution of ethyl [2-(toluene-4-sulfonyloxy)ethoxy]acetate (3.90 g, 12.9 mmol) in N,N-dimethylformamide (10 ml) was added dropwise to a mixture of ethyl 4-methyl-1H-indole-2-carboxylate (2.50 g, 12.3 mmol), 60% sodium hydride (0.50 g, 12.5 mmol) and N,N-dimethylformamide (45 ml) at room temperature, and the resulting mixture was stirred at room temperature 7 hours. The reaction mixture was poured into a 10% aqueous sodium chloride solution and extracted with ethyl acetate, and the extract solution was washed with a 5% aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the resulting residue was purified by a silica gel column chromatography (eluent:ethyl acetate:n-hexane= 2:98) to obtain 1.86 g of ethyl 1-[(2-ethoxycarbonylmethoxy)ethyl]-4-methyl-1H-indole-2-carboxylate as a colorless oil. 1 Hnmr (CDCl3) delta: 1.23(3H, t, J=7.3 Hz), 1.42(3H, t, J=7.3 Hz), 2.55(3H, s), 3.91(2H, t, J=5.9 Hz), 3.98 (2H, s), 4.16(2H, q, J=7.3 Hz), 4.37(2H, q, J=7.3 Hz), 4.78(2H, t, J=5.9 Hz), 6.94(1H, d, J=6.9 Hz), 7.24(1H, dd, J=6.9, 6.9 Hz), 7.35(1H, s), 7.36(1H, d, J=6.9 Hz).

16732-80-2, The synthetic route of 16732-80-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Limited; US5834454; (1998); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-57-3,Ethyl 5-nitro-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

5-Nitro-1 H-indole-2-carboxylic acid ethyl ester (14.9 mmol) was suspended in acetone(50 ml) and added to a mixture of titanium(lll) chloride (91ml, >10% in 2M hydrochloric acid) and ammonium acetate (265ml, 4M). The reaction was stirred for 2h and neutralized with saturated sodium hydrogen carbonate. The mixture was extracted with ethyl acetate (100ml) and the organic layer dried (MgSO4). The solvent was removed in vacuo to give a light brown solid which was purified by silica chromatography to give the title compound as an off-white solid (1.57g) m/z = 205 in MS ES+.

16732-57-3, As the paragraph descriping shows that 16732-57-3 is playing an increasingly important role.

Reference£º
Patent; MEDIVIR AB; WO2007/6714; (2007); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

133831-28-4, Methyl 3-Formylindole-6-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium methoxide (1 g, 0.018 mol) was added in one portion to a mixture of 2-diethylphosphonyl-2H-1,4-benzoxazin-3(4H)-one (3.42 g, 0.012 mol) and 6-methoxycarbonylindol-3-carboxaldehyde (2.55 g, 0.012 mol) in methanol (60 ml). The reaction mixture was refluxed for 21 h, then cooled at room temperature and the precipitated solid was collected by filtration, washed with methanol and dried. Yield 2.78 g (87%) as a mixture of isomers., 133831-28-4

As the paragraph descriping shows that 133831-28-4 is playing an increasingly important role.

Reference£º
Patent; Abbott GmbH & Co. KG; US7049312; (2006); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26340-49-8,2-Iodo-1H-indole,as a common compound, the synthetic route is as follows.

To a solution of 6 (6.97 g, 28.68 mmol) in CH2Cl2 (96 mL) at 0 C was added methyl vinyl ketone(4.02 g, 57.35 mmol) and InCl3 (0.32 g, 1.45 mmol). The mixture was stirred at 0 C for 1 h and warmedto RT. After 3 h, the reaction mixture was quenched with sat. aq. NaHCO3 (80 mL) and extracted withCH2Cl2 (2 x 80 mL). The organic layers were combined, washed with brine (80 mL), dried over MgSO4,and concentrated in vacuo. The residue was purified by recrystallization from hexane/CH2Cl2 (5:1, 30mL) to afford 7 (7.38 g, 82% yield) as a light yellow crystal. The filtrate was concentrated in vacuo andthe residue was purified by flash chromatography (silica gel, hexane/AcOEt = 6:1) to afford 7 (0.75 g,8% yield) as a light yellow crystal. Keto indole 7 was prepared in total 90 % yield.

26340-49-8, The synthetic route of 26340-49-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Miyamoto, Hiroshi; Hirano, Tomohiro; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu; Tetrahedron; vol. 69; 45; (2013); p. 9481 – 9493;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

80360-20-9, 1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Thiosemicarbazide (1 mmol) and potassium hydroxide(1 mmol) were dissolved in 10 mL ethanol and stirred for 30 min.The resulting solution was added to a solution of compound 5a(1 mmol) in 10 mL ethanol. The mixturewas stirred at 110 C for 3 h.The reaction was cooled, which resulted in a white precipitate thatwas then recrystallized in alcohol to obtain compound 8a. Thecompounds 8b-8l were obtained using the same method as that for8a., 80360-20-9

As the paragraph descriping shows that 80360-20-9 is playing an increasingly important role.

Reference£º
Article; Song, Mingxia; Wang, Shiben; Wang, Zengtao; Fu, Zhiyang; Zhou, Shengchao; Cheng, Huabin; Liang, Zhuo; Deng, Xianqing; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 108 – 118;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103858-52-2,Ethyl 4-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of compound 33 (10.0 g, 39.4 mmol) in a mixture of dioxane (200 mL) and water (50 mL) were added potassium vinyltrifluoroborate (11.0 g, 82.1 mmol), triethylamine (30 mL, 248 mmol) and Pd(dppf)C12 (1.00 g, 1.37 mmol). The mixture was stirred at 80C for48h. The mixture was concentrated under vacuum, and the residue was dissolved in ethyl acetate. The solution was washed with water and concentrated under reduced pressure. The obtained material was purified by silica gel column chromatography to give 2.50 g (12.4 mmol, 38%) of compound 63., 103858-52-2

The synthetic route of 103858-52-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AICURIS GMBH & CO. KG; DONALD, Alastair; URBAN, Andreas; BONSMANN, Susanne; WEGERT, Anita; GREMMEN, Christiaan; SPRINGER, Jasper; (376 pag.)WO2019/86141; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles