Tag: M.W:200-300

942-26-7,942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A flask was charged with 5-chlorotryptamine hydrochloride (5 g, 0.0649 mol), 0.5 M hydrochloric acid(130 mL), and the substituted benzaldehyde (1.5 eq). The mixture was refluxed for 14 hr, cooled to roomtemperature, and vacuum filtered. The solid was resuspended in acetic acid (100 mL), stirred for 1 hr, andvacuum filtered. The solid was resuspended in ethyl acetate (100 mL), stirred for 1 hr, and vacuumfiltered to obtain the pure scaffold as a solid.

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Tikhmyanova, Nadezhda; Paparoidamis, Nicholas; Romero-Masters; Feng, Xin; Mohammed, Farheen Sultana; Reddy, Poli Adi Narayana; Kenney, Shannon C.; Lieberman, Paul M.; Salvino, Joseph M.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 16; (2019); p. 2259 – 2264;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

942-26-7, 5-Chlorotryptamine hydrochloride is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

942-26-7, Triethylamine (1.93 mL; 13.78 mmol) was added at 0 C. to a mixture of 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (1.3 g; 5.51 mmol) and 3-(chloromethyl)benzoyl chloride (1.13 g; 5.79 mmol) in dichloromethane (75 mL). The mixture was stirred for 20 minutes at room temperature and was evaporated to dryness. The residue was purified by flash chromatography on silica gel (eluent 2 to 20% ethyl acetate in dichloromethane) to furnish 1.45 g (76%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-3-(chloromethyl)benzamide as a white solid. [0561] ESI/APCI(+): 347 (M+H), 369 (M+Na); ESI/APCI(-): 345 (M-H). [0562] 1H NMR (DMSO-d6) delta 11.04 (s, 1H); 8.68 (t, 1H); 7.91 (s, 1H); 7.80 (d, 1H); 7.63 (s, 1H); 7.59 (d, 1H); 7.47 (t, 1H); 7.35 (d, 1H); 7.28 (s, 1H); 7.06 (dd, 1H); 4.82 (s, 2H); 3.52 (q, 2H), 2.93 (t, 2H).

As the paragraph descriping shows that 942-26-7 is playing an increasingly important role.

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Patent; Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Veronica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick; US2013/274260; (2013); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

84807-09-0, 4-(Piperazin-1-yl)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,84807-09-0

EXAMPLE 12 1-[N-(2-nitrophenyl)-2-aminoethyl]-4-(4-indolyl)piperazine A mixture containing 0.49 g of N-(2-chloroethyl)-2-nitroaniline, prepared according to the procedure described by Ramage G. R. et al. in J. Chem. Soc. 4406-4409 (1952), 0.55 g of 1-(4-indolyl)piperazine (prepared according to WO 95/33743), 1 mL of triethylamine and 3 mL of DMF was heated at reflux while stirring under nitrogen for 2.5 h. After cooling at room temperature, the mixture was poured into H2 O, extracted with CH2 Cl2, and the organic phase dried on anhydrous Na2 SO4 and evaporated to dryness. The residue was purified via flash chromatography (EtOAc-petrolium ether 3:7) giving 0.35 g (40percent) of the title compound. 1 H-NMR (CDCl3, delta): 8.60-8.45 (br, 1H, aniline NH), 8.18 (dd, 1H, aniline H3), 8.20-8.10 (br, 1H, indole NH), 7.43 (td, 1H, aniline H5), 7.20-7.05 (m, 3H, indole H3,6,7), 6.85 (dd, 1H, aniline H4), 6.70-6.57 (m, 2H, aniline H6 and indole H5), 6.50 (t, 1H, indole H2), 3.45 (q, 2H, NHCH2 CH2), 3.35-3.25 (m, 4H, piperazine protons), 3.85-2.70 (m, 6H, NHCH2 CH2 and piperazine protons).

The synthetic route of 84807-09-0 has been constantly updated, and we look forward to future research findings.

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Patent; Recordati S.A. Chemical and Pharmaceutical Company; US6071920; (2000); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

16066-91-4, 5-Iodo-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction was performed in high pressure autoclave of 100 mL capacity manufactured by M/s Amar Industries. Toluene (10 mL), Pd(acac)2 (3 mg, 1 mol %), and dppm (7.7 mg, 2 mol %) were added to the autoclave reactor. To this solution iodobenzene (204 mg, 1.0 mmol), n-hexadecane (50 mg, internal GC standard), TMEDA (N,N,N’,N’-tetramethylethylenediamine, 1 equiv) were added. The mixture was flushed twice with CO/H2 1:1, then synthetic gas pressure was adjusted to 10 bar and the mixture was heated at 100 C for 10 h. After completion of reaction, the reaction mixture was cooled to room temperature. The light yellow colored solution was evaporated and residue obtained was purified by column chromatography (silica gel, mesh size 60-120) using pet ether/ethyl acetate (95:05) as eluent to get the desired formylated product., 16066-91-4

The synthetic route of 16066-91-4 has been constantly updated, and we look forward to future research findings.

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Article; Singh, Abhilash S.; Bhanage, Bhalchandra M.; Nagarkar, Jayashree M.; Tetrahedron Letters; vol. 52; 18; (2011); p. 2383 – 2386;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.618910-07-9,8-Methoxy-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole,as a common compound, the synthetic route is as follows.

General procedure: To degassed tetrahydrofuran (5 mL) was added chloro-(2-dicyclohexylphosphino-2′,6′-diisopropoxy-1 ,1 ‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct (PdRuPhos G1 ) (0.017 g, 0.024 mmol), 2-dicyclohexylphosphino-2?,6’-diisopropoxybiphenyl (RuPho) (0.011 g, 0.024 mmol), the title compound from Preparative Example 2 (0.05 g, 0.024 mmol), and the commercially available 4-(6-bromobenzo[d]thiazol-2-yl)morpholine (0.073 g, 0.029 mmol). Then, a 1 M solution of lithium bis(trimethylsilyl)amide (LiHMDS) in tetrahydrofuran (1 mL, 1 mmol) was added. The resulting reaction mixture was heated at reflux for 2 hours. The reaction mixture was cooled to room temperature, dissolved in dichloromethane (100 mL). The organic phase was washed with water and brine and dried over Na2S04. The solvent was removed under reduced pressure. The crude product was purified on a silica gel column using a Biotage Isolera One purification system employing an ethyl acetate/n-heptane gradient (80/20 => 100/0) to afford the title compound (0.070 g, 69 %)., 618910-07-9

618910-07-9 8-Methoxy-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 24206808, aindole-building-block compound, is more and more widely used in various fields.

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Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

166104-19-4, tert-Butyl 5-nitro-1H-indole-1-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 5-nitro-1H-indole-1-carboxylate (525 mg, 2.0 mmol) in ethyl acetate (8 ml) was added 10percent palladium on carbon (50 mg). Stir overnight at room temperature in a hydrogen atmosphere. Suction filteration, The filtrate was evaporated under reduced pressure to give a white solid (469 mg, 100percent), 166104-19-4

As the paragraph descriping shows that 166104-19-4 is playing an increasingly important role.

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Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Wen Liang; Zheng Jinfu; Zhang Jin; Wu Shoutao; Yuan Xiaofeng; Lin Runfeng; Wang Xiaojun; Zuo Yinglin; Zhang Yingjun; (21 pag.)CN104311541; (2017); B;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

80360-20-9, 1-(Phenylsulfonyl)-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 3 (1 mmol), corresponding rhodanine (1 mmol), 10 drops glacial acetic acid and10 drops piperidine in ethanol (20 mL) was refluxed for 16 h. After cooling, the solvent was evaporatedin vacuo, followed by the purification of the resulting residue by silica gel column chromatography(dichloromethane/methanol = 100/1 or 150/1) to obtain a yellow solid 5-11., 80360-20-9

As the paragraph descriping shows that 80360-20-9 is playing an increasingly important role.

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Article; Song, Ming-Xia; Li, Song-Hui; Peng, Jiao-Yang; Guo, Ting-Ting; Xu, Wen-Hui; Xiong, Shao-Feng; Deng, Xian-Qing; Molecules; vol. 22; 6; (2017);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.942-26-7,5-Chlorotryptamine hydrochloride,as a common compound, the synthetic route is as follows.,942-26-7

Step A: 1-[2-(5-Chloro-1H-indol-3-yl)ethyl]piperidin-2-one To a solution of 100 g of 5-chlorotryptamine hydrochloride in 1.4 litres of 2-methoxyethanol there are added 60 g of Na2CO3. The reaction mixture is stirred at reflux under nitrogen. A solution of 111.2 g of 5-bromovalerate in 200 ml of 2-methoxyethanol is added dropwise over a period of 5-6 hours and the mixture is heated at reflux for 24 hours. After cooling, the reaction mixture is filtered over Celite and the filtrates are concentrated under reduced pressure. The oil is extracted with 500 ml of CH2Cl2 and 3000 ml of water. The organic phases are washed with saturated sodium chloride solution, then dried over Na2SO4 and concentrated under reduced pressure. The solid is recrystallized from a 9/1 acetone/pentane mixture to yield 107 g of the expected product. Melting point. 155 C. Mass spectrometry (EI, m/z): 276.8 (M+).

942-26-7 5-Chlorotryptamine hydrochloride 2827494, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; LES LABORATOIRES SERVIER; US2009/298813; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885520-70-7,4-Bromo-6-fluoro-1H-indole,as a common compound, the synthetic route is as follows.

885520-70-7, To a solution of 4-bromo-6-fluoro-indole (2 g, 9.38 mmol) in anhydrous tetrahydrofuran (30 mL) cooled in an ice bath was added sodium hydride (0.452 g, 11.3 mmol, 60percent in mineral oil). The reaction mixture was stirred under nitrogen for 10 min before benzenesulfonyl chloride (1.44 mL, 11.3 mmol) was added. The black solution was allowed to warm to room temperature over 4 h. TLC and LCMS indicated completion of the reaction. Saturated aqueous ammonium chloride solution was added slowly, and the resulting solution was extracted with ethyl acetate (2*). The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude solid was triturated with ethanol. The resulting beige solid was collected by filtration to give 4-bromo-6-fluoro-1-(phenylsulfonyl)-1H-indole (2.6 g, 79percent yield).

The synthetic route of 885520-70-7 has been constantly updated, and we look forward to future research findings.

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Patent; PMV Pharmaceuticals, Inc.; Vu, Binh; Dominique, Romyr; Li, Hongju; (222 pag.)US2017/240525; (2017); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

348-36-7, Ethyl 5-fluoro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6.1. Ethyl 2-(ethoxycarbonyl)-5-fluoro-alpha-methylene-1H-indole-3-acetate. A solution of 37.2 g (180 mmol) of ethyl 5-fluoro-1H-indole-2-carboxylate, 25.8 g (222 mmol) of ethyl pyruvate and 31 ml of concentrated sulphuric acid in 400 ml of acetic acid is stirred for 20 h. The solvent is evaporated under reduced pressure, the residue is taken up in water and ethyl acetate, the organic phase is separated, washed with a dilute aqueous ammonia solution and then with a saturated aqueous sodium chloride solution and dried over sodium sulphate, and the solvent is evaporated under reduced pressure. 37.1 g (122 mmol) of solid product are obtained, which product is used as is in the following stage.

348-36-7, 348-36-7 Ethyl 5-fluoro-1H-indole-2-carboxylate 2727899, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Synthelabo; US6075021; (2000); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles