With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111258-23-2,Methyl 4-methoxy-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
4-methoxy-1H-indole-2-carboxylic acid methyl ester (7) (3g, 10 mmol, 1 equiv) was dissolved in DMF (4 mL) and the resulting solution was added dropwise to a suspension of NaH (60% in mineral oil) (0.6g, 15 mmol, 1.5 equiv) in DMF (10 mL) at 0 C. The mixture was stirred for 20 min at 0 C and benzyl bromide (2 mL, 17 mmol, 1.7 equiv) was added dropwise. The mixture was allowed to warm to room temperature and stirred for 1h, before quenching the reaction by pouring it onto ice. The organic layer was diluted with EtOAc (20 mL) and separated from the aqueous one. The latter was extracted with EtOAc (3¡Á20 mL). The combined organic layers were wash with water (20 mL) and brine (20 mL), were dried over MgSO4, filtered and concentrated in vacue to afford as yellow solid, which did not require further purification.
111258-23-2, 111258-23-2 Methyl 4-methoxy-1H-indole-2-carboxylate 688172, aindole-building-block compound, is more and more widely used in various.
Reference£º
Article; Yang, Yan-Fang; Li, Lian-Hua; He, Yu-Tao; Luo, Jian-Yi; Liang, Yong-Min; Tetrahedron; vol. 70; 3; (2014); p. 702 – 707;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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