Tag: M.W=400-600

Kaewtong, Chatthai; Wanich, Suchana; Wanno, Banchob; Tuntulani, Thawatchai; Pulpoka, Buncha published the artcile< An ultra-low detection limit gold(III) probe based on rhodamine-covalent hydrogel sensor>, SDS of cas: 950846-89-6, the main research area is gold probe rhodamine covalent hydrogel sensor; Agarose hydrogel; DFT; gold; rhodamine; sensor.

A highly sensitive and selective optical chemosensor (Arg-Rhoen) for determination of Au3+ was prepared by covalent immobilization of rhodamine ethylenediamine on agarose gel. Spectrophotometric studies of complex formation, chem. structures and purity of the hydrogel sensor were carried out using TGA, NMR, TEM, and IR. The complexation study results indicated that this probe can selectively detect Au3+ via a metal ion chelation-induced ring-opening reaction, and then caused a remarkable color change from colorless to pink and a strong fluorescence enhancement. Theor. DFT calculation results suggested that the hydrogel sensor formed stable complexes with Au3+ through a large number of cation-dipole interactions. Reusability has been established by repeatedly dipping and rinsing the hydrogel in aqueous Au3+ and EDTA in basic solutions We believe that this approach may provide an easily measurable and inherently sensitive method for Au3+ detection in environmental and biol. applications.

Environmental Technology published new progress about Absorption. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, SDS of cas: 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cheng, Zhiyang; Qin, Qingwen; Jia, Hui; Li, Juan; Yan, Fanyong; Meng, Xia; Wang, Jie published the artcile< Scale evaluation and antiscalant testing based on fluorescent probe technology in RO process>, Reference of 950846-89-6, the main research area is aminotrimethylene phosphonic acid fluorescent probe reverse osmosis.

Inventing the technol. based on fluorescent probes to detect antiscalants in reverse osmosis (RO) concentrated water is of great significance for guiding the use of antiscalant and the control of scale. In this study, Amino trimethylene phosphonic acid (ATMP) was taken as the representative of the antiscalant, and a new fluorescent probe for ATMP detection was designed and synthesized. The new fluorescent probe showed high accuracy for ATMP detection (R2 > 0.94) and resistance to the interference of ions (change rate <3%). Further, the use of probe to detect the antiscalant in RO concentrate and realize the evaluation of the scaling phenomenon was carried out. The model of the relationship between the probe fluorescence intensity and the concentration of precipitated ions was established to analyze the scale evaluation mechanism of the probe. Meanwhile, Critical fluorescence intensity (CFI) was introduced for scale evaluation. The results showed that the new probe could accurately judge the formation of scale under the condition of different antiscalant concentrations, and 926 ± 20 a.u. was judged as CFI for scaling evaluation. Finally, results of the new probe detection in RO scale evaluation test were consistent with the membrane flux and SEM detection, indicating that the probe can accurately evaluate scale during the RO operation. This research can provide tech. support for the precise application of antiscalants and scale inhibition. Journal of Membrane Science published new progress about Electric conductivity. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Reference of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhang, Mengyao; Shen, Chuanchuan; Jia, Ting; Qiu, Jianwen; Zhu, Hu; Gao, Yong published the artcile< One-step synthesis of rhodamine-based Fe3+ fluorescent probes via Mannich reaction and its application in living cell imaging>, Name: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is iron ion bioimaging fluorescent probe Mannich reaction; Fe(3+); Fluorescence probe; Mannich reaction; Rhodamine.

Four rhodamine-based fluorescent probes M1-M4 were synthesized in one step using Mannich reaction. The Mannich reaction based approach has the advantages of simplicity, good yield and excellent at. economy. The structures were determined by 1H NMR, 13C NMR, IR and HRMS. The probe M3 as a representative compound was characterized by single-crystal X-ray analyses. The fluorescence and absorbance spectra research of the probes demonstrated that they could be used as Fe3+-selective fluorescent probes with good sensitivity, excellent linearity, and outstanding anti-interference in acetonitrile/Tris-HCl buffer solution (3:7, V/V; pH = 7.4). Moreover, confocal laser scanning microscopy experiments have proven that the probe M3 was successfully used for fluorescence imaging in MCF-7 cells.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Biocompatibility. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Name: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xing, Fei; Zhang, Qilong; Gao, Lingfeng; Zheng, Gengxiu published the artcile< Fabrication of a fluorescent probe for in-situ and ratiometric visualization of autophagy>, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one, the main research area is fluorescent probe autophagy; Autophagy; Fluorescent probe; Ratiometric; pH sensitive.

In situ and real-time visualization of autophagy process is of vital importance for fundamental researches in biol. However, fluorescent probes for autophagy were rarely reported, which greatly hindered the study on autophagy. A fluorescent probe was rationally designed and fabricated for the ratiometric visualization of autophagy. The probe targeted non-lysosome organelles in healthy cells, and gave blue emission. During autophagy, the organelles together with the probe were delivered into acid lysosomes, and gave red fluorescence. In this way, the autophagy process could be monitored in ratiometric manner. The starvation induced autophagy was successfully visualized by the probe, and the inhibition effect of chloroquine to autophagy was also observed The authors expect that the probe can serve as powerful tool for the study of autophagy and relative areas.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Autophagy. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Recommanded Product: 2-(2-Aminoethyl)-3′,6′-bis(diethylamino)spiro[isoindoline-1,9′-xanthen]-3-one.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Adak, Arup Kumar; Purkait, Rakesh; Manna, Saikat Kumar; Ghosh, Bankim Chandra; Pathak, Sudipta; Sinha, Chittaranjan published the artcile< Fluorescence sensing and intracellular imaging of Pd2+ ions by a novel coumarinyl-rhodamine Schiff base>, Electric Literature of 950846-89-6, the main research area is coumarinyl rhodamine Schiff base fluorescence imaging Palladium ion.

Coumarinyl-rhodamine, HCR, served as an extremely selective sensor for Pd2+ ions in ethanol/H2O (8 : 2, volume/volume, HEPES buffer, pH 7.2) solution and the limit of detection (LOD) was 18.8 nM (3σ method). The free sensor, HCR, was weakly emissive and in the presence of Pd2+, the color changed from straw to pink with very strong emission at 598 nm in the presence of eighteen other cations. A plausible mechanism involved opening of the spirolactam ring of rhodamine on interaction with Pd2+, which was justified by structure optimization and transition energy calculations using the DFT technique. HCR underwent 1 : 1 complexation with Pd2+, which was confirmed via the Job’s plot, mass spectra and Benesi-Hildebrand plot (association constant Ka, 9.1 × 104 M-1). A sep. in vitro experiment showed that HCR could specifically sense Pd2+ in MCF7 (human breast adenocarcinoma) cell lines.

New Journal of Chemistry published new progress about Complexation. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Electric Literature of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hamstra, Anna; Cai, Yajie; Reynolds, Zachary; Griffins, Cody S.; Rheingold, Arnold L.; Schaaf, Nicholas J.; Sinn, Ekkehard; Bates, Jefferson E.; Weerasinghe, Aruna J. published the artcile< Utilizing Experiment and Theory to Evaluate Rhodamine B ethylenediamine as a Fluorescent Sensor for G-type Nerve Agents>, Electric Literature of 950846-89-6, the main research area is rhodamine ethylenediamine diethyl chlorophosphate fluorescence excited state; Computational; Fluorescence; Nerve Agents; Rhodamine; Sensor.

Nerve gas mimic binding with Rhodamine B ethylenediamine (1) was studied in organic media. Binding of the nerve gas mimic, di-Et chlorophosphate (DCP), with the probe generated a non-fluorescent intermediate and a fluorescent product. Fluorescent and non-fluorescent products generated were identified using mass spectrometry and X-ray crystallog. Time-dependent d. functional theory calculations were also used to investigate the electronic structure of the fluorescent probe in the ground and lowest lying π → π* singlet excited state. Though good agreement between theory and experiment can be obtained for the intense peak in the exptl. spectrum using non-hybrid functionals, care must be taken when modeling these complexes due to the appearance of an n → π* transition that is too low in energy and appears to fall in the shoulders of the π → π* transitions.

Journal of Fluorescence published new progress about Excited singlet state. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Electric Literature of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kroeger, A. Pia P.; Paats, Jan-Willem D.; Boonen, Roy J. E. A.; Hamelmann, Naomi M.; Paulusse, Jos M. J. published the artcile< Pentafluorophenyl-based single-chain polymer nanoparticles as a versatile platform towards protein mimicry>, COA of Formula: C30H36N4O2, the main research area is pentafluorophenyl single chain polymer nanoparticle protein mimicry versatile platform.

Proteins are biopolymers folded into 3D-structures and are omnipresent in biol. systems, where they fulfil a wide array of complex functions. Mimicking the exceptional characteristics of proteins with synthetic analogs may likewise give unprecedented control over a nanomaterial’s pharmacokinetic behavior, enabling controlled delivery of therapeutics or imaging agents. Recent advances in polymer science have enabled the formation of bio-inspired single-chain polymer nanoparticles (SCNPs), which are formed by intramol. collapse of individual polymer chains, and display sizes ranging from 5-20 nm. Here, we describe the preparation of SCNPs containing activated ester moieties, facilitating SCNP functionalization without altering its backbone structure. Pentafluorophenyl-functional SCNPs were prepared through intramol. thiol-Michael addition crosslinking of thiol-functional precursor copolymers. Post-formation functionalization of the resulting SCNPs through substitution of the activated pentafluorophenyl esters with a variety of amines resulted in a series of water-soluble SCNPs with fluorescent labels, ‘click’ functionality, amino acids and even peptides. This synthetic strategy offers a straightforward method towards SCNP modification and SCNP-protein hybrids, giving access to easily adjustable physicochem. properties and protein mimicry.

Polymer Chemistry published new progress about Cytotoxicity. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, COA of Formula: C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mehta, Ruhi; Luxami, Vijay published the artcile< A Novel ′On-Off′ Rhodamine Based Sensor for Colorimetric Detection of CN- and Its Application as Encoder-Decoder and Molecular Keypad Lock>, Reference of 950846-89-6, the main research area is rhodamine based sensor colorimetric detection mol keypad lock.

A novel rhodamine-phenalenedicarbonitrile based “”on-off”” sensor (Rho-Pdc) has been synthesized which is characterized by 1H NMR, 13C NMR and mass spectrometry. The photophys. studies of the dyad suggest its existence in spirolactam ring open form of rhodamine. ICT (Intramol. Charge Transfer) active sensor displays an absorption band at 577 nm with a shoulder at 520 nm and fluorescence band at 593 nm. The treatment of dyad Rho-Pdc with different anions shows its sensitivity and selectivity towards CN- ions in aqueous methanolic solution with lowest detection limit of 0.13 μM and the binding constant was determined to be 1.17 × 104 M-1 by applying Benesi-Hildebrand equation. The presence of CN- ions hinder the ICT process of dyad Rho-Pdc and shows a blue shift in absorption band of dyad Rho-Pdc with formation of new band at 488 nm as well as decrease in the intensity of emission band. Rho-Pdc has also been used for the colorimetric detection of CN- ions among different anions and concentrations The reversibility of Rho-Pdc.CN-complex has been achieved with Fe3+ ions which formed the basis for the construction of multiple mol. logic circuits.

ChemistrySelect published new progress about Absorption. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Reference of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Song, Fan; Shao, Xiaotao; Zhu, Jing; Bao, Xiaofeng; Du, Lei; Kan, Chun published the artcile< Reversible ""turn-off-on"" fluorescence response of Fe(III) towards Rhodamine B based probe in vivo and plant tissues>, Electric Literature of 950846-89-6, the main research area is fluorescence iron Rhodamine B probe plant tissue.

A Fe3+-specific probe (N-TC)(I) based on Rhodamine B was designed and synthesized. N-TC has a good spectral response to Fe3+ in the EtOH/H2O solution (1:1, volume/volume, HEPES, 0.5 mM, pH = 7.38) with low detection limits and high binding constants N-TC displays the reversible “”turn-off-on”” fluorescence response with 1:1 binding stoichiometry. It is further proven to be practical in sensitively monitoring trace Fe3+ in environmental water specimens. Biol. experiments demonstrated that N-TC can be resp. used as a probe for detection of Fe3+ in living cells, animals and plant tissues.

Tetrahedron Letters published new progress about Fluorescence. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Electric Literature of 950846-89-6.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ye, Ya-Xi; Guan, Jing; Chen, Xin-Yue; Yu, Ya-Wen; Xu, Zhu-Min; Zeng, Shang-Ming-Zhu; Wang, Zhong-Chang; Wang, Bao-Zhong; Jiao, Qing-Cai; Zhu, Hai-Liang published the artcile< A new fluorescently labeled bisphosphonate for theranostics in tumor bone metastasis>, Application of C30H36N4O2, the main research area is bisphosphonate hydroxyapatite bone metastasis fluorescence; Bisphosphonate; Bone metastasis; Fluorescence imaging; Hydroxyapatite; pH-sensitivity.

Bone metastasis of malignant solid tumors has become one of the most serious complications, especially in breast cancer, which was particularly challenging for early detection and treatment in clin. practice. In this work, we reported a new fluorescently labeled bisphosphonate for bone metastasis detection of breast cancer. The designed probes were based on Rhodamine B and bisphosphonate as recognition group, which can specifically target hydroxyapatite (HA) existed in bone tissue. After the osteoclasts were adsorbed on the bone surface, the surrounding microenvironment was acidified, causing the HA to locally dissolve. The probe bound to the HA was then released, and realized the fluorescence turn on under acidic conditions. In vitro experiments showed that G0 was more excellent than G2 owing to shorter connecting arm. Subsequently, we proved that G0 could combine with HA rapidly and exhibit excellent response in solid state. More importantly, we established a model of bone metastasis with MDA-MB-231 cells which was similar to the clin. cases and evaluated the theranostics value of G0 prospectively, which provide the potential application prospect in clin.

Talanta published new progress about Antitumor agents. 950846-89-6 belongs to class indole-building-block, and the molecular formula is C30H36N4O2, Application of C30H36N4O2.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles