C-Methylenation of anilines and indoles with CO2 and hydrosilane using a pentanuclear zinc complex catalyst was written by Takaishi, Kazuto;Kosugi, Hiroyasu;Nishimura, Ritsuki;Yamada, Yuya;Ema, Tadashi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Category: indole-building-block This article mentions the following:
The one-step C-methylenation of anilines and indoles with CO2 and phenylsilane was catalyzed by a pentanuclear ZnII complex to give diarylmethanes via geminal C-H and C-C bond formation. It was proposed that the zinc-hydride complex generated in-situ was a catalytically active species and that bis(silyl)acetal was a key intermediate. When aniline was used as a substrate, both the C-methylenation and N-methylation proceeded. In the experiment, the researchers used many compounds, for example, 5-Methoxy-1-methyl-1H-indole (cas: 2521-13-3Category: indole-building-block).
5-Methoxy-1-methyl-1H-indole (cas: 2521-13-3) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Category: indole-building-block
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles