On October 14, 2004, Tang, Peng Cho; Liang, Congxin; Miller, Todd; Lipson, Kenneth E. published a patent.Recommanded Product: 52537-00-5 The title of the patent was Preparation of 5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors. And the patent contained the following:
The title compounds [I; R1 and R2 combine to form (un)substituted optionally fused heterocyclic ring; R3-R5 = H, alkyl, hydroxyalkyl, etc.; or R3 and R4 may combine to form a cyclic 6-membered alicyclic ring which may be substituted with one or more lower alkyl] that modulate the activity of protein kinases (“”PKs””) and are therefore useful in treating disorders related to abnormal PK activity (no biol. data), were prepared General method of synthesis of the compounds I by condensation of oxindoles and aldehydes (preparation of intermediates is given) is described. Eighty-two compounds I (e.g., II) were prepared Pharmaceutical compositions comprising the compounds I, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5
The Article related to indolinone sulfonamido preparation protein kinase inhibitor antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles