On May 8, 2008, Tanimori, Shinji; Kirihata, Mitsunori published a patent.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the patent was Preparation of indole compounds by cyclocondensation of haloanilines. And the patent contained the following:
Title compounds I [R1 = (un)substituted alkyl, cycloalkyl, heterocyclyl, alkynyl, alkoxy, aryl ether group, cyano, carboxyl, carbamoyl, etc.; R2 electron-withdrawing group; R3 = H, any group given for R2; n = 0-4], useful as intermediates for drugs, agrochems., electronic materials, etc., are prepared by reacting haloanilines II (R3, n = same as above; Hr = halo) with R1COCH2R2 (R1, R2 = same as above) in the presence of catalysts. Thus, Me 3-oxo-4-chlorobutanoate was added dropwise to a mixture of NaH and DMSO and the reaction mixture was treated with 2-IC6H4NH2, CuI, and L-proline at room temperature for 5 h to give 23% Me 2-chloromethyl-1H-indole-3-carboxylate. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate
The Article related to indole compound preparation, haloaniline cyclocondensation oxochlorobutanoate cuprous iodide catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles