On August 31, 2007, Tanimori, Shinji; Ura, Haruna; Kirihata, Mitsunori published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles. And the article contained the following:
The copper-catalyzed one-step synthesis of 2,3-disubstituted indoles I (R = Me, Et, tert-Bu, Me2C:CHCH2CH2, etc., R1 = Me; R = Ph, 2-naphthyl, 2-furyl, 2-thienyl, 2-pyridyl, R1 = Et) from readily available starting materials, 2-iodoaniline and various β-keto esters was described. The advantage of this method is the use of cheap catalysts and simple exptl. procedures under mild reaction conditions. As the substituted indole derivatives are important starting materials for the synthesis of biol. active indole alkaloids and drug candidates, this method would have potential usage for these purposes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate
The Article related to iodoaniline keto ester copper binol ullmann coupling heterocyclization, indole alkoxycarbonyl preparation, alkoxycarbonylindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles