Effects of 6-methoxytetrahydro-β-carboline on 5-hydroxytryptamine binding in rat brain was written by Taylor, Dorothy L.;Silverman, Peter B.;Ho, Beng T.. And the article was included in Journal of Pharmacy and Pharmacology in 1984.HPLC of Formula: 20315-68-8 This article mentions the following:
6-Methoxytetraydro-β-carboline (I) [20315-68-8] competes for 5-HT [50-67-9] binding sites in rat brain in vitro and in vivo. The β-carboline is more active at the type 1, 5-HT, than the type 2, spiperone, receptors in vitro. Following injection into rats, I decreases 5-HT but not spiperone binding to the brain cortex. The ineffectiveness of I on spiperone binding in vivo corresponds with the results obtained in vitro. Thus, the effect of I on central 5-HT binding may be a significant aspect of its 5-hydroxytryptaminergic activity. In the experiment, the researchers used many compounds, for example, 6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8HPLC of Formula: 20315-68-8).
6-Methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (cas: 20315-68-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 20315-68-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles