On November 29, 2007, Teegarden, Bradley; Chapman, Dennis; Choi, Juyi; Feichtinger, Konrad; Han, Sangdon; Jayakumar, Honnappa; Tran, Thuy-Anh; Xu, Jingdong; Zou, Ning published a patent.Related Products of 52537-00-5 The title of the patent was Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto and their preparation. And the patent contained the following:
The present invention pertains to certain compounds of formula I and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy hypertension and pain. The invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered sep. or together. Compounds of formula I wherein X is O and S; V is O and NH; W and Z are independently (un)substituted C1-4 alkylene; R1 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-7 cycloalkyl; R2 is H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, etc.; R3 is H, C2-6 alkenyl, C1-6 alkyl, C1-6 alkylcarboxamide, C2-6 alkynyl, carboxamide, CN, etc.; R4a is H, R4b is H, (un)substituted C1-12 acyl, (un)substituted carbo-C1-6 alkoxy, (un)substituted CO2-aryl, etc.; R5, R6 and R7 are independently H, C1-6 acyl, C1-6 acyloxy, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl, etc.; R8 is (un)substituted C1-8 alkyl, (un)substituted (hetero)aryl, (un)substituted C3-10 cycloalkyl and (un)substituted heterocyclyl; and their pharmaceutically acceptable salts, hydrates, and solvates thereof, are claimed. Example compound II•TFA was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their 5-HT2A modulatory activity (some data given). The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Related Products of 52537-00-5
The Article related to primary amine preparation 5ht2a serotonin receptor modulator treatment disease, pyrazolylphenyl amine preparation 5ht2a serotonin receptor modulator treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Related Products of 52537-00-5
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles