Application of 1008-89-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone. Author is Miao, Wenjun; Ni, Chuanfa; Xiao, Pan; Jia, Rulong; Zhang, Wei; Hu, Jinbo.
A novel nickel-catalyzed reductive cross-coupling between aryl iodides RI (R = Ph, 9-ethyl-9H-carbazol-3-yl, 1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl, etc.) and alkyl 2-pyridyl sulfones I (R1 = Me, CHF2; R2 = H, CF3; R3 = H, C(O)OMe; R4 = H, C(O)OEt) enables C(sp2)-C(sp2) bond formation through selective C(sp2)-S bond cleavage, which demonstrates the new reactivity of 2-PySO2CF2H reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls II under mild reaction conditions without pregeneration of arylmetal reagents.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles