An article Facile preparation and preliminary cytotoxicity evaluation of dehydroepiandrosterone C-16 spiro-pyrrolidine derivatives WOS:000570115900003 published article about CYCLOADDITION; STEROIDS in [Tao, Hong-Wen; Peng, Wen-Yu; Yuan, Jiang-Chun; Li, Qiang; Zeng, Lu-Yao; Yu, Xian-Yong; Yi, Ping-Gui] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Sch Chem & Chem Engn, Xiangtan 411201, Hunan, Peoples R China in 2021, Cited 22. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
A facile synthesis of dehydroepiandrosterones derived by C-16 spiro-pyrrolidine and their cytotoxic evaluation are reported. Seven derivatives, 3a-3g, were prepared by the [3 + 2] cycloaddition reaction of the 16-arylidene dehydroepiandrosterone and the azomethine ylide, where the azomethine ylide was generated in situ from 11H-indeno[1,2-b]quinoxalin-11-one and sarcosine. Their cytotoxicity was evaluated on brine shrimp assay and the bioactivities represented by LC50 values were found in the range of 6.19-27.2 mu g/mL. Among them, the activities of 3d and 3g are the best, as manifested by LC50 values less than 10 mu g/mL. All products were confirmed by NMR, HR MS and X-ray analysis.
Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 123-11-5
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles