Chemistry, like all the natural sciences, Name: JANEX-1, begins with the direct observation of nature¡ª in this case, of matter.202475-60-3, Name is JANEX-1, SMILES is OC1=CC=C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)C=C1, belongs to indole-building-block compound. In a document, author is Ertugrul, Berrak, introduce the new discover.
Access to C5-Alkylated Indolines/Indoles via Michael-Type Friedel-Crafts Alkylation Using Aryl-Nitroolefins
A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy composed of Zn(OTf)(2)-catalyzed Friedel-Crafts alkylation of N-benzylindolines with nitroolefins, and a series of diverse indolines was first obtained in up to 99% yield. This reaction provides a direct and practical route to a variety of the C5-alkylated indolines which were also utilized for accessing corresponding indoles. Indoline derivatives with free NH groups could be obtained through an N-deprotection reaction. Moreover, the primary alkyl nitro groups in both indolines and indoles are amenable to further synthetic elaborations, thereby broadening the diversity of the products.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 202475-60-3. Name: JANEX-1.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles