The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C10H7NO3, 28166-41-8, Name is α-Cyano-4-hydroxycinnamic Acid, SMILES is OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1, in an article , author is Thrimurtulu, Neetipalli, once mentioned of 28166-41-8.
Palladium Catalyzed Regioselective C4-Arylation and Olefination of Indoles and Azaindoles
A convergent strategy for the synthesis of biologically relevant C4-substituted indole scaffolds was demonstrated using Pd(II)-catalyzed remote C-H functionalization of indoles and azaindoles. The reaction displays high regioselectivity for the C4-position of indole-3-carbaldehydes using glycine as an inexpensive transient directing group. Notable features of this transformation include the selective formation of six-membered palladacyle and excellent functional group tolerance.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles