Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Safety of 4-Fluoroindole, Which mentioned a new discovery about 387-43-9
Silica Gel Assisted Reductive Cyclization of 2-Nitro-beta-piperidinostyrenes, Derived from 2-Nitrotoluenes, to Indoles
An efficient modification of the Leimgruber-Batcho method of indole synthesis has been devised that facilitates the synthesis of a variety of 2,3-unsubstituted indoles containing halogen, methoxy and benzyloxy groups, from 2-nitrotoluenes, in high yields.The modified method involves the condensation of 2-nitrotoluenes with tripiperidinomethane followed by the reductive cyclization of the intermediate 2-nitro-beta-piperidinostyrenes with iron and acetic acid in refluxing toluene in the presence of silica gel (column chromatography grade, 60-200 mesh).
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 387-43-9, help many people in the next few years.Safety of 4-Fluoroindole
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles