Quality Control of 4′-Hydroxyacetophenone. Recently I am researching about MONO-MANNICH-BASES; CARBONIC-ANHYDRASE INHIBITORS; CORRESPONDING AZINE DERIVATIVES; ACETYLCHOLINE ESTERASE; BIOLOGICAL EVALUATION; HUMAN HEPATOMA; CYTOTOXICITY; ANTICANCER; PURIFICATION; BIOACTIVITY, Saw an article supported by the Research Foundation of Ataturk University Erzurum (Turkey)Ataturk University. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Kucukoglu, K; Gul, HI; Taslimi, P; Gulcin, I; Supuran, CT. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and Alzheimer’s disease. Keeping this in mind, N, N’-bis[(1-aryl-3-heteroaryl) propylidene] hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. According to the activity results, the most effective inhibitory compounds were in R-series with the K-i values of 203 +/- 55-473 +/- 67 nM and 200 +/- 34-419 +/- 94 nM on hCA I, and hCA II, respectively. N, N’-Bis[1-(4-fluorophenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N8, in N-series, N, N’-Bis[1-(4-hydroxyphenyl)-3-(piperidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, P4, in P-series, and N, N’-bis[1-(4-chlorophenyl)-3-(pyrrolidine-1-yl) pro-pylidene] hydrazine dihydrochlorides, R5, in R-series were the most powerful compounds against hCA I with the K-i values of 438 +/- 65 nM, 344 +/- 64 nM, and 203 +/- 55 nM, respectively. Similarly, N8, P4, and R5 efficiently inhibited hCA II isoenzyme with the K-i values of 405 +/- 60 nM, 327 +/- 80 nM, and 200 +/- 34 nM, respectively. On the other hand, P-series compounds had notable inhibitory effect against AChE than the reference compound tacrine and the K-i values were between 66 +/- 20 nM and 128 +/- 36 nM. N, N’-Bis[1-(4-fluorophenyl)-3-(piperidine-1-yl) propylidene] hydrazine dihydrochlorides, P7, was the most potent compound on AChE with the K-i value of 66 +/- 20 nM. The other most promising compounds, N, N’-bis[1-(4-hydroxyphenyl)-3-(morpholine-4-yl) propylidene] hydrazine dihydrochlorides, N4 in N-series and N, N’-bis[1-(4-hydroxyphenyl)-3-(pyrrolidine-1-yl) propylidene] hydrazine dihydrochlorides, R4 in R-series were againts AChE with the K-i values of 119 +/- 20 nM, 88 +/- 14 nM, respectively.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles