In an article, author is Mao, Jianyou, once mentioned the application of 80-08-0, Recommanded Product: 80-08-0, Name is Dapsone, molecular formula is C12H12N2O2S, molecular weight is 248.3, MDL number is MFCD00007887, category is indole-building-block. Now introduce a scientific discovery about this category.
Synthesis of Indoles through Domino Reactions of 2-Fluorotoluenes and Nitriles
Indoles are essential heterocycles in medicinal chemistry, and therefore, novel and efficient approaches to their synthesis are in high demand. Among indoles, 2-aryl indoles have been described as privileged scaffolds. Advanced herein is a straightforward, practical, and transition-metal-free assembly of 2-aryl indoles. Simply combining readily available 2-fluorotoluenes, nitriles, LiN(SiMe3)(2), and CsF enables the generation of a diverse array of indoles (38 examples, 48-92 % yield). A range of substituents can be introduced into each position of the indole backbone (C4 to C7, and aryl groups at C2), providing handles for further elaboration.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles