Category: indole-building-block. Alcazar, O; Hernandez, LF; Tschiggfrie, A; Muehlbauer, MJ; Bain, JR; Buchwald, P; Abdulreda, MH in [Alcazar, Oscar; Hernandez, Luis F.; Tschiggfrie, Ashley; Buchwald, Peter; Abdulreda, Midhat H.] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA; [Alcazar, Oscar; Hernandez, Luis F.; Tschiggfrie, Ashley; Buchwald, Peter; Abdulreda, Midhat H.] Univ Miami, Miller Sch Med, Cell Transplant Ctr, Miami, FL 33136 USA; [Muehlbauer, Michael J.; Bain, James R.] Duke Univ, Duke Mol Physiol Inst, Med Ctr, Durham, NC 27708 USA; [Buchwald, Peter] Univ Miami, Dept Mol & Cellular Pharmacol, Miller Sch Med, Miami, FL 33136 USA; [Abdulreda, Midhat H.] Univ Miami, Dept Surg, Miller Sch Med, Miami, FL 33136 USA; [Abdulreda, Midhat H.] Univ Miami, Dept Microbiol & Immunol, Miller Sch Med, Miami, FL 33136 USA; [Abdulreda, Midhat H.] Univ Miami, Dept Ophthalmol, Miller Sch Med, Miami, FL 33136 USA published Feasibility of Localized Metabolomics in the Study of Pancreatic Islets and Diabetes in 2019, Cited 61. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.
(1) Background: Disruption of insulin production by native or transplanted pancreatic islets caused by auto/allo-immunity leads to hyperglycemia, a serious health condition and important therapeutic challenge due to the lifelong need for exogeneous insulin administration. Early metabolic biomarkers can prompt timely interventions to preserve islet function, but reliable biomarkers are currently lacking. We explored the feasibility of localized metabolomics where initial biomarker discovery is made in aqueous humor samples for further validation in the circulation. (2) Methods: We conducted non-targeted metabolomic studies in parallel aqueous humor and plasma samples from diabetic and nondiabetic mice. Metabolite levels and associated pathways were compared in both compartments as well as to an earlier longitudinal dataset in hyperglycemia-progressor versus non-progressor non-obese diabetic (NOD) mice. (3) Results: We confirmed that aqueous humor samples can be used to assess metabolite levels. About half of the identified metabolites had well-correlated levels in the aqueous humor and plasma. Several plasma metabolites were significantly different between diabetic and nondiabetic animals and between males and females, and many of them were correlated with the aqueous humor. (4) Conclusions: This study provides proof-of-concept evidence that aqueous humor samples enriched with islet-related metabolites and representative of the immediate islet microenvironment following intraocular islet transplant can be used to assess metabolic changes that could otherwise be overlooked in the general circulation. The findings support localized metabolomics, with and without intraocular islet transplant, to identify biomarkers associated with diabetes and islet allograft rejection.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles