Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1,4-Dibromobutane, is researched, Molecular C4H8Br2, CAS is 110-52-1, about Regioselective Hydroalkylation of Vinylarenes by Cooperative Cu and Ni Catalysis.COA of Formula: C4H8Br2.
Disclosed here is a dual copper and nickel catalytic system with a silyl hydride source for promoting the linear selective hydroalkylation of vinylarenes ArCHCH2 (Ar = 4-fluorophenyl, pyridin-2-yl, 2-methyl-1,3-benzoxazol-6-yl, etc.). This carbon-carbon bond-forming protocol is applied to couple a variety of functionalized vinylarenes with alkyl halides RX (R = phenylethyl, cyclohexyl, 3-(2H-1,3-benzodioxol-5-yloxy)propyl, etc.; X = Br, I) applying a nickel(II) NNN pincer complex in the presence of an NHC-ligated copper catalyst. This combination allows for a 1 mol% loading of the nickel catalyst leading to turnover numbers of up to 72. Over 40 examples are presented, including applications for pharmaceutical diversification. Labeling experiments demonstrated the regioselectivity of the reaction and revealed that the copper catalyst plays a crucial role in enhancing the rate for formation of the reactive linear alkyl nickel complex. Overall, the presented work provides a complimentary approach for hydroalkylation reactions, while providing a preliminary mechanistic understanding of the cooperativity between the copper and nickel complexes.
Compound(110-52-1)COA of Formula: C4H8Br2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1,4-Dibromobutane), if you are interested, you can check out my other related articles.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
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