The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex.Ding, Decai; Lan, Yun; Lin, Zhiyang; Wang, Chuan published the article 《Synthesis of gem-Difluoroalkenes by Merging Ni-Catalyzed C-F and C-C Bond Activation in Cross-Electrophile Coupling》 about this compound( cas:29046-78-4 ) in Organic Letters. Keywords: gem difluoroalkene preparation carbon fluoride carbon carbon activation; regioselective nickel catalyzed cross electrophile coupling; cyclobutanone oxime ester trifluoromethyl alkene coupling radical reaction. Let’s learn more about this compound (cas:29046-78-4).
By merging C-F and C-C bond activation in the cross-electrophile coupling, we developed an efficient cyanide-free synthesis of diverse functional-group-rich cyano-substituted gem-difluoroalkenes using cyclobutanone oxime esters and trifluoromethyl alkenes as precursors. Notably, this Ni-catalyzed reaction is bestowed with broad substrate scope, low catalyst loading, complete regioselectivities, and high tolerance of a wide range of sensitive functional groups. Preliminary mechanistic studies indicate that an iminyl radical-initiated C-C bond cleavage is involved in the reaction pathway.
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