The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Acidic properties of benzimidazoles and substituent effects. IV. Relationship between the acidities of N’-(substituted phenyl)arylamidines and ring closures to imidazole, the main research direction is benzimidazole substituent effect acidity; amidine aryl cyclization substituent effect; phenylenediamine cyclocondensation pyridinecarboxylic acid; LFER acidity benzimidazole pyridyl.Product Details of 2208-59-5.
Benzimidazoles I (R = H, Me, Cl, MeO, NO2; R1 = Ph, pyridinyl) were prepared by cyclocondensation of 1,2-(H2N)2C6H3R with R1CO2H in polyphosphoric acid at 170-80° or by cyclocondensation of 1,2-(H2N)2C6H3R with R1Me in the presence of S. Alternatively, I were also prepared by cyclization of amidines RC6H4NHC(:NH)R1 (II) by successive treatment with aqueous NaOCl and then with Na2CO3. Cyclization of II (R = C-3 substituted) by the latter method gave mixtures of C-7 and C-5 substituted benzimidazoles which were separated by crystallization Acidities of II increased with increasing electron withdrawing power of R, and, as the acidity of II increased, yields of I from cyclization of II decreased. Acidities of C-7 substituted I were correlated by the Taft equation with ρ = 0.45, whereas acidities of C-5 substituted I (R1 = pyridyl) were correlated by the Hammett equation with ρ = 1.3.
After consulting a lot of data, we found that this compound(2208-59-5)Product Details of 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles