Recommanded Product: 150-19-6. Recently I am researching about BIOLOGICAL EVALUATION; DIHYDROFOLATE-REDUCTASE; INHIBITORS; ACID; DNA, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773692]; Science and Technology Department of Jilin Province [20180311016YY]; Department of Education of Jilin Province [JJKH20191070KJ]; Health Department of Jilin Province [2018ZC034]; Doctoral Foundation of Jilin Medical University [JYBS2018007]. Published in SPRINGER in DORDRECHT ,Authors: Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol
In the present investigation, a series of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties were synthesized and their structures were confirmed by different spectral tools. The biological evaluation in vitro revealed that some of the target compounds exerted good antibacterial and antifungal activity in comparison with the reference drugs. Among these novel hybrids, compound 10d showed the most potent activity with minimum inhibitory concentration values (MIC) of 0.5 mu g/mL againstS. aureus4220, MRSA 3506 and E. coli 1924 strain. The cytotoxic activity of the compounds 6d, 6m,10d and 10g was assessed in MCF-7 and HeLa cells. Growth kinetics study showed significant inhibition of bacterial growth when treated with different conc. of 10d. In vitro enzyme study implied that compound 10d exerted its antibacterial activity through DHFR inhibition. Moreover, significant inhibition of biofilm formation was observed in bacterial cells treated with MIC conc. of 10d as visualized by SEM micrographs. [GRAPHICS] .
Recommanded Product: 150-19-6. Welcome to talk about 150-19-6, If you have any questions, you can contact Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles