Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, HPLC of Formula: https://www.ambeed.com/products/27538-09-6.html, 27538-09-6, Name is 5-Ethyl-4-hydroxy-2-methylfuran-3(2H)-one, SMILES is O=C1C(C)OC(CC)=C1O, belongs to indole-building-block compound. In a document, author is Gu, Yanlong, introduce the new discover.
A three-component reaction of indoles, alpha-bromoacetaldehyde acetals, and ketones was developed by using bismuth(III) triflate as the catalyst to realize a straightforward approach for synthesizing carbazole derivatives. The reaction was established mechanistically through the autotandem catalysis of Bi(OTf)(3) in the following two steps: (i) Friedel-Crafts-type alkylation of indole with alpha-bromoacetaldehyde acetal, which produced a tryptaldehyde-type intermediate and (ii) [4 + 2] annulation of this intermediate with the ketone component.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 27538-09-6. HPLC of Formula: https://www.ambeed.com/products/27538-09-6.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles