An article Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids WOS:000461402400039 published article about BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; MOLECULAR DOCKING; ANTICANCER ACTIVITY; PYRAZOLE; DESIGN; APOPTOSIS; POTENT; AGENTS; METASTASIS in [Dai, Hong; Huang, Meiling; Wang, Senling; Shi, Yujun; Yao, Yong; Ge, Shushan; Ling, Yong] Nantong Univ, Coll Chem & Chem Engn, Nantong 226019, Peoples R China; [Dai, Hong; Huang, Meiling; Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Ge, Shushan; Zhang, Yanan; Ling, Yong] Nantong Univ, Sch Pharm, Nantong 226001, Peoples R China; [Qian, Jianqiang; Liu, Ji; Meng, Chi; Li, Yangyang; Ming, Guxu; Zhang, Ting; Zhang, Yanan; Ling, Yong] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China in 2019, Cited 49. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Application In Synthesis of 3-(Trifluoromethyl)phenol
A series of hybrids 10a-v based on coumarin/pyrazole oxime have been synthesized, and exhibit good to excellent antitumor activities. Compound 10n has shown remarkable anticancer effect on SMMC-7721 cells (IC50 = 2.08 mu M), which is considerably lower than 5-FU (IC50 = 37.8 mu M) and similar to ADM (IC50 = 2.67 mu M), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that 10n also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-beta 1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, 10n also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. Our findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. (C) 2019 Elsevier Masson SAS. All rights reserved.
Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Dai, H; Huang, ML; Qian, JQ; Liu, J; Meng, C; Li, YY; Ming, GX; Zhang, T; Wang, SL; Shi, YJ; Yao, Y; Ge, SS; Zhang, YN; Ling, Y or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles