Chemistry is an experimental science, HPLC of Formula: https://www.ambeed.com/products/315-30-0.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 315-30-0, Name is 1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one, molecular formula is C5H4N4O, belongs to indole-building-block compound. In a document, author is Zidar, Nace.
A series of 3-methyl-2-phenyl-1H-indoles was prepared and investigated for antiproliferative activity on three human tumor cell lines, HeLa, A2780, and MSTO-211H, and some structure-activity relationships were drawn up. The GI(50) values of the most potent compounds (32 and 33) were lower than 5 mu M in all tested cell lines. For the most biologically relevant derivatives, the effect on human DNA topoisomerase II relaxation activity was investigated, which highlighted the good correlation between the antiproliferative effect and topoisomerase II inhibition. The most potent derivative, 32, was shown to induce the apoptosis pathway. The obtained results highlight 3-methyl-2-phenyl-1H-indole as a promising scaffold for further optimization of compounds with potent antiproliferative and antitopoisomerase II activities.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 315-30-0, in my other articles. HPLC of Formula: https://www.ambeed.com/products/315-30-0.html.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles