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Alkylation of Indoles with alpha,beta-Unsaturated Ketones using Alumina in Hexanes
We evaluated the influence of solvent on the alumina-promoted C3-alkylation of indoles with alpha,beta-unsaturated ketones. We found that lipophilic solvents were generally superior to hydrophilic ones with hexanes offering the 3-alkyl indole products in high yields. Thus, we demonstrate an inexpensive and procedurally simple new process that pairs acidic alumina with hexanes to achieve this important Michael alkylation. The substrate scope includes twenty-four examples with reaction yields ranging from 61 to 96%. (Figure presented.).
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 20289-26-3, help many people in the next few years.Formula: C15H13NO
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles