4264-35-1, Name is 1-(1H-Indol-2-yl)ethanone, belongs to indole-building-block compound, is a common compound. 4264-35-1. In an article, authors is Akimoto, Hiroshi, once mentioned the new application about 4264-35-1.
Synthesis of 3-Amino-5H-pyrido<4,3-b>indoles, Carcinogenic gamma-Carbolines
The carcinogenic gamma-carbolines 3-amino-1,4-dimethyl-5H-pyrido<4,3-b>indole (1) and 3-amino-1-methyl-5H-pyrido<4,3-b>indole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-gamma-carbolines.This was followed by dehydrogenation to the gamma-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of gamma-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-<1-(dimethylamino)alkyl>indoles.
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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles