Reference of 1953-54-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1953-54-4, Name is 5-Hydroxyindole, molecular formula is C8H7NO. In a article，once mentioned of 1953-54-4
We report the synthesis and evaluation of a series of N-benzoylindole derivatives as novel potential imaging agents for beta-amyloid plaques. In vitro binding studies using Abeta1-40 aggregates versus [ 125I]TZDM showed that all these derivatives demonstrated high binding affinities (Ki values ranged from 8.4 to 121.6 nM). Moreover, two radioiodinated compounds [125I]7 and [125I]14 were prepared. Autoradiography for [125I]14 displayed intense and specific labeling of Abeta plaques in the brain sections of AD model mice (C57, APP/PS1) with low background. In vivo biodistribution in normal mice exhibited sufficient initial brain uptake for imaging (2.19% and 2.00% ID/g at 2 min postinjection for [125I]7 and [125I]14, respectively). Although additional modifications are necessary to improve brain uptake and clearance from the brain, the N-benzoylindole may be served as a backbone structure to develop novel beta-amyloid imaging probes.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1953-54-4, and how the biochemistry of the body works.Electric Literature of 1953-54-4
Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles