One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 603288-22-8, Name is LY2090314, formurla is C28H25FN6O3. In a document, author is Yang Zhonghua, introducing its new discovery. Quality Control of LY2090314.
Using choline chloride as cheap and safe accelerator was efficient to promote the Yonemitsu type condensation of indole, benzaldehyde, and malononitrile. More importantly, introducing right amount of water in reaction system was crucial to get desired 3-substituted indoles in good to excellent yields. Due to the catalyst has excellent solubility in aqueous ethanol, the final concoction was easy to separate. Many desired products could be obtained after filtration and washed ethanol without further purification. Catalyst could further reuse for five more reaction cycles with negligible loss in activity.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles