Recently I am researching about IN-VITRO; DRUG-DELIVERY; BRASILIENSIS; GEL; FORMULATION; EPIDEMIOLOGY; SCHENCKII; HYDROGEL; RELEASE; UPDATE, Saw an article supported by the CAPESCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); CNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [305915/2017-7, 303713/2014-3]; FAPERJFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) [E-26/2002.800/2017, E-26/2003.085/2016, E-26/200.930/2017]. Application In Synthesis of Benzyl Alcohol. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Ferreira, PG; Noronha, L; Teixeira, R; Vieira, I; Borba-Santos, LP; Vicosa, A; de Moraes, M; Calil-Elias, S; de Freitas, Z; da Silva, FC; Rozental, S; Futuro, DO; Ferreira, VF. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
The aim of this study was to develop a microemulsion (ME) formulation containing an association of itraconazole (ITC) and clotrimazole (CLT) as a transdermal delivery system for the treatment of sporotrichosis. Pseudoternary phase diagrams were constructed to optimize the ME formulation. The ME formulation selected contained 1% (w/w) ITC and 1% (w/w) CLT and was composed of 23.07% Tween (R) 60 (surfactant), 23.07% propylene glycol (cosurfactant/cosolvent), 30.77% benzyl alcohol (oil), and 21.09% water. The ITC/CLT-loaded ME (ITC/ CLT-ME) had a droplet size value of 217 +/- 0.9 nm, with a poly-dispersity index of 0.5 +/- 0.1. Permeation experiments on pig ear skin were conducted for ITC/CLT-ME, and the results indicated that the drug permeation performance was influenced by CLT, indicating that CLT acts as a promoter enhancer. In the in vitro antifungal activity assay using Sporothrix brasiliensis yeast, the inhibition halo produced by ITC/CLT-ME exhibited a mean diameter of 43.67 +/- 2.31 mm. The ITC/CLT-ME formulation did not cause skin irritation in mice. The results suggest that ITC/CLT-ME is a promising tool for the transdermal treatment of sporotrichosis. (c) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Ferreira, PG; Noronha, L; Teixeira, R; Vieira, I; Borba-Santos, LP; Vicosa, A; de Moraes, M; Calil-Elias, S; de Freitas, Z; da Silva, FC; Rozental, S; Futuro, DO; Ferreira, VF or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles