Grell, Yvonne; Xie, Xiulan; Ivlev, Sergei I.; Meggers, Eric published the article 《Enantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by a Non-C2-Symmetric Chiral-at-Rhodium Catalyst》. Keywords: chiral rhodium catalyst preparation; fluorinated alpha chlorinated acyl pyrazole enantioselective preparation; acyl pyrazole chiral rhodium catalyst fluorination chlorination.They researched the compound: Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane( cas:132098-59-0 ).Related Products of 132098-59-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:132098-59-0) here.
A non-C2-sym. and sterically demanding chiral-at-rhodium catalyst was demonstrated to efficiently catalyze the highly enantioselective α-fluorination [up to >99% enantiomeric excess (ee)] and α-chlorination (up to 98% ee) of N-acyl pyrazoles to afford α-fluorinated/chlorinated N-acyl pyrazoles I [R = Pr, Ph, 3-thienyl, ets.; R1 = F, Cl] in high yields. Based on two sterically distinct cyclometalating ligands, the nonracemic rhodium(III) catalyst could conveniently be accessed in an enantiomerically pure fashion (>99% ee) via an established auxiliary-mediated approach. Comparison of the catalytic performance with the related C2-sym. rhodium catalysts revealed the explicit superiority of the non-C2-sym. design for the presented α-halogenation reactions, which were generally featured by a very simple synthetic protocol.
In addition to the literature in the link below, there is a lot of literature about this compound(Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)methane)Related Products of 132098-59-0, illustrating the importance and wide applicability of this compound(132098-59-0).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles