Computed Properties of C7H8O2. Nesaragi, AR; Kamble, RR; Dixit, S; Kodasi, B; Hoolageri, SR; Bayannavar, PK; Dasappa, JP; Vootla, S; Joshi, SD; Kumbar, VM in [Nesaragi, Aravind R.; Kamble, Ravindra R.; Kodasi, Barnabas; Hoolageri, Swati R.; Bayannavar, Praveen K.] Karnatak Univ, Dept Studies Chem, Dharwad 580003, Karnataka, India; [Dixit, Shruti; Vootla, Shyamkumar] Karnatak Univ, Dept Biotechnol & Microbiol, Dharwad 580003, Karnataka, India; [Dasappa, Jagadeesh Prasad] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Konaje, India; [Joshi, Shrinivas D.] SETs Coll Pharm, Dept Pharmaceut Chem, Novel Drug Design & Discovery Lab, Dharwad 580002, Karnataka, India; [Kumbar, Vijay M.] Maratha Mandals NGH Inst Dent Sci & Res Ctr, Cent Res Lab, Belagavi 590010, India published Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies in 2021, Cited 24. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.
A modest, competent and green synthetic procedure for novel coumarinyl-1,3,4-oxadiazolyl-2mercaptobenzoxazoles 8i-t has been reported. Analysis of the docked (PDB ID: 5IKR; A-Chain) poses of the compounds illustrated that they adopt identical conformations to the extremely selective COX-2 inhibitor. The biological outcomes as well as computational study suggested that the compounds originated to have elevated resemblance towards COX-2 enzyme than COX-1. The compounds 8i, 8l, 8q, 8r, 8s and 8t emerged as most potent and selective COX-2 inhibitors in contrast with Mefenamic acid. The selectivity index of 8l, 8n and 8r was respectively found to be 33.95, 20.25 and 24.98 which manifested their high selectivity against COX-2. Interestingly, the compounds which were active as COX-2 inhibitors were also active as antioxidant agents.
Computed Properties of C7H8O2. Welcome to talk about 150-76-5, If you have any questions, you can contact Nesaragi, AR; Kamble, RR; Dixit, S; Kodasi, B; Hoolageri, SR; Bayannavar, PK; Dasappa, JP; Vootla, S; Joshi, SD; Kumbar, VM or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles